ABSTRACT:
In the present study, Gymnemic acid nanoparticles was prepared by using PLGA (Polylactic-co-glycolicacid) polymer, surfactant sodium alginate and evaluate its ideal concentration of polymer based on its in vitro release profile for a period of 24hrs. The nanoparticles were prepared by solvent evaporation method by using various concentration of PLGA (Polylactic-co-glycolic acid) and the different formulations are (GLPNP1, GLPNP2, GLPNP3). The nanoparticles were evaluated by particle size, zeta potential, drug content, entrapment efficiency and the invitro drug release. There is no incompatibility between drug and other excipients used in the formulation, have been proved in the preformulation studies. Based on the entrapment efficiency and invitro drug release profile the formulation which contain 500mg of PLGA (Polylactic-co-glycolic acid) (GLPNP3) was selected as a best formulation for the control release of Gymnemic acid for a period of 24hrs.
Cite this article:
Sridevi. S, N. Harikrishnan. Formulation and Evaluation of Gymnemic Acid Loaded PLGA Nanoparticles. Research Journal of Pharmacy and Technology. 2024; 17(9):4481-5. doi: 10.52711/0974-360X.2024.00693
Cite(Electronic):
Sridevi. S, N. Harikrishnan. Formulation and Evaluation of Gymnemic Acid Loaded PLGA Nanoparticles. Research Journal of Pharmacy and Technology. 2024; 17(9):4481-5. doi: 10.52711/0974-360X.2024.00693 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-9-54
REFERNCES:
1. Kanchan R. Pagar, Sarika V. Khandbahale. A Review on Novel Drug Delivery System: A Recent Trend. Asian J. Pharm. Tech. 2019; 9(2): 135-140. doi: 10.5958/2231-5713.2019.00023.0
2. Avinash B. Thalkari, Pawan N. Karwa, Priyanka S. Chopane, Nareshkumar R. Jaiswal. Nanotechnology: The Future of Cancer. Asian J. Pharm. Tech. 2019; 9(1): 40-48. doi: 10.5958/2231-5713.2019.00008.4
3. Sirisha, Praveena R. A Complete Review - Nanoparticles Targeting to Brain. Asian J. Res. Pharm. Sci. 2020; 10(3):199-203. doi: 10.5958/2231-5659.2020.00038.7
4. Sweetha G., Sangeetha B., Prabhu S.. A Review on Curcumin Nanoparticles and Its Controlled Delivery to Treat Degenerative Diseases. Asian J. Pharm. Tech. 2013; 3(4): 218-222.
5. Manohar D. Kengar, Amit A. Jadhav, Suraj B. Kumbhar, Rahul P. Jadhav. A Review on Nanoparticles and its Application. Asian J. Pharm. Tech. 2019; 9(2): 115-124. doi: 10.5958/2231-5713.2019.00020.5
6. Aabasaheb B. Tambve, Prakash D. Jadhav, Mayur N. Ghotkar, Ashwinkumar S. Chougule, Smita P. Borkar. A Review on Nanoparticles. Asian J. Pharm. Tech. 2020; 10(2): 118-120. doi: 10.5958/2231-5713.2020.00020.3
7. Ashok P., Meyyanathan S. N., Jawahar N., R. Vadivelan. Irbesartan Formulation and Evaluation of Loaded Solid Lipid Nanoparticles by Microemulsion Techinque. Asian J. Pharm. Tech. 2020; 10(4): 228-230. doi: 10.5958/2231-5713.2020.00038.0
8. Nikita D. Gidde, Manojkumar M. Nitalikar, Indrayani D. Raut. Nanocomposites: A Review on Current Status. Asian Journal of Pharmacy and Technology. 2021; 11(3): 231-7. doi: 10.52711/2231-5713.2021.00038
9. S. Viswanathan, N. Vinoth Kumar, Prathiba Srinivasan, S. Prabhu. Nanoparticle-Mediated Drug Delivery Systems. Research J. Engineering and Tech. 2013; 4(4): 295-299.
10. Rajeev Kumar Dang, Deepam Goyal, SS Dhami, Amit Chauhan. Effect of Nanoparticles based Lubricants on Static Thermal Behaviour of Journal Bearings: A Review. Research J. Engineering and Tech. 2017; 8(2): 149-153. doi: 10.5958/2321-581X.2017.00023.X
11. Choi SW, Kim JH. Design of surface-modified poly (d,l-lactide-co-glycolide) nanoparticles for targeted drug delivery to bone, Journal of Controlled Release. 2007; 122: 24–30.
12. Kawashima Y. Nanoparticulate systems for improved drug delivery. Advanced Drug Delivery Reviews. 2001; 47: 1–2.