Author(s):
Amitkumar J. Vyas, Harshal M. Vadile, Jayshree P. Godhaniya, Chirag D. Jadav, Ajay I. Patel, Ashok B. Patel, Ashvin V. Dudhrejiya, Sunny R. Shah, Urvi J. Chotaliya, Devang B. Sheth
Email(s):
harshalvadile8469@gmail.com
DOI:
10.52711/0974-360X.2024.00668 
Address:
Amitkumar J. Vyas1, Harshal M. Vadile1*, Jayshree P. Godhaniya1, Chirag D. Jadav1, Ajay I. Patel1, Ashok B. Patel2, Ashvin V. Dudhrejiya1, Sunny R. Shah1, Urvi J. Chotaliya1, Devang B. Sheth3
1B. K. Mody Government Pharmacy College, Rajkot, Gujarat, India, Postal Code: 360003.
2Government Pharmacy College, Gandhinagar, Gujarat, India.
3LM College of Pharmacy, Ahmedabad, Gujarat, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 9,
Year - 2024
ABSTRACT:
This study outlines a method using RP-HPLC to analyze Rosuvastatin calcium and Teneligliptin hydrobromide hydrate. The separation was accomplished at ?(245nm) with a 1mL/min F.R with [KH2PO4 buffer (pH 3): Methanol: Acetonitrile (75:20:5 %v/v)] using a C18 (25 cm x 4.6 mm, 5µm). Both were eluted with retention times of 3.19 min and 2.08 min respectively. Linearity was observed across a defined concentration range for both drugs, with high correlation coefficients. Accuracy of the method was confirmed through analysis of known concentrations, indicating its suitability for routine analysis of these compounds in a synthetic mixture.
Cite this article:
Amitkumar J. Vyas, Harshal M. Vadile, Jayshree P. Godhaniya, Chirag D. Jadav, Ajay I. Patel, Ashok B. Patel, Ashvin V. Dudhrejiya, Sunny R. Shah, Urvi J. Chotaliya, Devang B. Sheth. RP-HPLC Method Development and Validation for Simultaneous Estimation of Rosuvastatin calcium and Teneligliptin hydrobromide hydrate in Synthetic Mixture. Research Journal of Pharmacy and Technology. 2024; 17(9):4325-8. doi: 10.52711/0974-360X.2024.00668
Cite(Electronic):
Amitkumar J. Vyas, Harshal M. Vadile, Jayshree P. Godhaniya, Chirag D. Jadav, Ajay I. Patel, Ashok B. Patel, Ashvin V. Dudhrejiya, Sunny R. Shah, Urvi J. Chotaliya, Devang B. Sheth. RP-HPLC Method Development and Validation for Simultaneous Estimation of Rosuvastatin calcium and Teneligliptin hydrobromide hydrate in Synthetic Mixture. Research Journal of Pharmacy and Technology. 2024; 17(9):4325-8. doi: 10.52711/0974-360X.2024.00668 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-9-29
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