Author(s):
Sofi N. Stiani, Yusransyah Yusransyah, Dede Septiana, Imam B. Sumantri
Email(s):
sofia240586@gmail.com
DOI:
10.52711/0974-360X.2024.00641 
Address:
Sofi N. Stiani1, Yusransyah Yusransyah1, Dede Septiana1, Imam B. Sumantri2*
1Department of Pharmaceutics, Pharmacy Study Program, STIKes Salsabila Serang, Indonesia.
2Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Sumatera Utara, Indonesia.
*Corresponding Author
Published In:
Volume - 17,
Issue - 9,
Year - 2024
ABSTRACT:
Serum has the advantage of having a high concentration of active ingredients so that the skin absorbs the effect the skin more quickly. Licorice root (Glycyrrhiza glabra) has skin-lightening agents. Glabridin is a compound that is productive as a skin lightener. This study aimed to determine the Formulation and evaluation of licorice root (G. glabra) ethanol extract serum as a facial brightener. The experimental procedure is to extract licorice simplicia by maceration method. Evaluation of the preparation includes organoleptic, pH, viscosity, spreadability, homogeneity, stability, and irritation test. We are testing skin-lightening activity using a skin tone chart. The evaluation results of the formulation meet the requirements of good serum, and the viscosity test meets the needs of SNI (16-4399-1996). The results showed that formulation III, containing 20% extract, had the best effect on facial brightening activity, marked by a change in skin color before use from 7 to 3. The results of statistical analysis using Kruskal Wallis and Paired Sample Test. The serum formulation with the addition of 20% licorice root extract had the highest facial brightening effect and was not significantly different from the positive control X.
Cite this article:
Sofi N. Stiani, Yusransyah Yusransyah, Dede Septiana, Imam B. Sumantri. Effectivity and Evaluation of Licorice Root (Glycyrrhiza glabra) Extract Serum Formula as a Facial Brightening. Research Journal of Pharmacy and Technology. 2024; 17(9):4142-8. doi: 10.52711/0974-360X.2024.00641
Cite(Electronic):
Sofi N. Stiani, Yusransyah Yusransyah, Dede Septiana, Imam B. Sumantri. Effectivity and Evaluation of Licorice Root (Glycyrrhiza glabra) Extract Serum Formula as a Facial Brightening. Research Journal of Pharmacy and Technology. 2024; 17(9):4142-8. doi: 10.52711/0974-360X.2024.00641 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-9-2
REFERENCES:
1. Arwanda D, Wulandari esa A, Saputra M rais P. Ideal White: Representation of Women's Skin Color in Vaseline Insta Fair Cosmetic Advertisements. Audience. 2022; 3(1).
2. Sukisman JM, Utami LSS. Fighting Skin Color Stigma against Women's Beauty Standards Through Ads. 2021; 5(1): 67–75. DOI: https://doi.org/10.24912/kn.v5i1.10150
3. Mustika R, Hindun S, Auliasari N. The Potential of Plants as Natural Face Lightening Rina. science and Health. 2020; 2(4): 558–62. DOI: https://doi.org/10.25026/jsk.v2i4.233
4. Allgisna KN, Hindun S, Rantika N. Review: Comparison of Several Fruit Peel Extracts as Anti-hyperpigmentation Review: science and health. 2021; 3(2): 335–342. DOI: https://doi.org/10.25026/jsk.v3i2.403
5. Soyata A, chaerunisaa AY. Whitening Agent : Mechanism, Natural Sources and Formulation Technology. 2021; 6(2): 169–86. DOI: https://doi.org/10.24198/mfarmasetika.v6i2.28139
6. Damle M. Glycyrrhiza glabra ( Liquorice ) - a potent medicinal herb. 2014; 2(2): 132–6.
7. Murphy MJ, Dow AA. Natural Cosmeutical Ingredients for the Management of Hyperpigmentation in Hispanic and Latino Women. 2021; 14(8): 52–6. Epub 2021 Aug 1.PMID: 34840659; PMCID: PMC8570660
8. Rakhmini A, Faridha I, Vitayan iMuchtar S, IlhamjayaPatellongi, Jaya patellongi I, Djawad K, et al. Comparison of 10%, 20% and 40% Licorice Extract Cream as Skin Lightening Agent. International Journal of Medical Reviews and Case Reports. 2018; 2(0): 1. DOI: 10.5455/IJMRCR.Licorice-Extract-Cream-as-Skin-Lightening-Agent
9. Farhamzah, Indrayati A. Formulation, Physical Stability Test and Compatibility of Anti-Aging Cosmetic Products in Serum Preparations. 2020;(December). DOI:10.36805/farmasi.v4i2.739
10. Alani BKH, Hussain MH, Ismael SB, Ibrahim RA, Okhti ZA. Biological activity of Green Nanoparticle Synthesized from Glycyrrhiza glabra in vitro and in vivo. Res J Pharm Technol. 2022; 15(12).
11. Muthmainnah. Phytochemical screening of secondary metabolites from the ethanol extract of pomegranate (Punica granatum L.) using the color test method. Pharmaceutical Media. 2017; 13(2). DOI: https://doi.org/1921107/jps.v7i2.8722
12. Anggarini D, Raharjeng SW, Safitri CINH, Pangestuti Z. Formulation and Evaluation of Essential Oil Based Anti-Acne Serum Curcuma zedoaria. 2021; 406–15. https://proceedings.ums.ac.id/index.php/snpbs/article/view/60
13. Kurniawati AY, Wijayanti ED. Characteristics of Facial Serum Preparation With Various Concentration Of Temu Giring (Curcuma heyneana) Fermented With Lactobacillus bulgaricus A. 2018; 1–8. https://repository.poltekkespim.ac.id/id/eprint/372
14. Liandhajani, Fitria N, Ratu AP. Characteristics and stability of cherry fruit extract serum (Muntingia calabura L.) with various concentrations. Pharmamedics. 2022; 7(1): 17–27. DOI: https://doi.org/10.47219/ath.v7i1.140
15. Pratiwi R iChi H, Apriwi N luh, Wahyuni IG. Formulation of Malaka Fruit Extract Serum (Phyllanthus emblica) as Anti Aging. metamorphosis. 2021; 8(2): 284–90. DOI: https://doi.org/10.24843/metamorfosa.2021.v08.i02.p12
16. Dwiastuti R, Ardiyati SE. Formulation of Lipid Nanoparticle Gel Preparations of Binahong Leaf Extract (Anredera cordifolia (Ten.) Steenis). Pharmacy Medical Journal. 2020;3(2):40–6. DOI: https://doi.org/10.35799/pmj.3.2.2020.32879
17. Leny, Ginting I, Sitohang tiary n, Hanum S fatimah, Hafiz I, Iskandar B. Formulation and Effectiveness Test of Yellow Pumpkin Body Scrub (Cucurbita moschata). 2021; 6(4): 375–85. DOI : http://dx.doi.org/10.24198/mfarmasetika.v6i4.35776
18. Lestari U, Farid F. Effectiveness Test of Natural Detoxification Facial Wash Gel Activated Charcoal Palm Shells Using Habatussaudah Scrub. Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021). 2022; 40(Iccscp): 169–73. DOI: https://doi.org/10.2991/ahsr.k.211105.024
19. Tomar S, Asif M. Pharmacognostical Identification of Glycyrrhiza glabra L. Root. Research Journal of Pharmacognosy and Phytochemistry. 2020; 12(2). DOI: https://doi.org/10.5958/0975-4385.2020.00016.3
20. Susanti S, Primadiamanti A, Ulfa AM. Physical evaluation of putri malu root extract ointment (Mimosa pudica L.) With variation of concentrations. 2022; 5(2): 188–202. DOI: https://doi.org/10.33024/jfm.v5i2.6967
21. Wendersteyt NV, Wewengkang DS, Abdullah SS. Antimicrobial Activity Test of Extracts and Ascidian Herdmania Momus Fractions from Bangka Likupang Island Waters Against Microbial Growth Staphylococcus aureus, Salmonella typhimurium and Candida albicans. Pharmacon. 2021; 10(1): 706. DOI: https://doi.org/10.35799/pha.10.2021.32758
22. Sogandi, Darma T syurya wan, Jannah R. Antibacterial Potential of Licorice Root Extract (Glycyrrhiza glabra L) against Bacillus cereus. Chemistry Science and Applications. 2019; 22(4): 105–11. DOI: https://doi.org/10.14710/jksa.22.4.105-111
23. Sathya S, Herath HM, Amarasinghe N, Suraweera R. Formulation development of cream Incorporating Extracts of Glycyrrhiza glabra (licorice). 2017; (September). DOI: http://dx.doi.org/10.4038/pjsl.v7i0.19
24. Gupta S, Bishnoi JP. Phytochemical screening of Terminalia arjuna and Glycyrrhiza glabra showing the effect of different drying techniques. Res J Pharm Technol. 2019; 12(4). DOI: https://doi.org/10.5958/0974-360X.2019.00259.2
25. Jain NK, Roy R, Pathan HK, Sharma A, Ghosh S, Kumar S. Formulation and evaluation of polyherbal aqueous gel from Psidium guajava, Piper betel and Glycerrhiza glabra extract for mouth ulcer treatment. Research Journal of Pharmacognosy and Phytochemistry. 2020; 12(3): 145. DOI: https://doi.org/10.5958/0975-4385.2020.00024.2
26. Gunjal SD, Shirolkar S V. Optimizations of spray drying process parameters for liquorice (Glycyrrhiza glabra linn.) extract. Res J Pharm Technol. 2018; 11(11). DOI: https://doi.org/10.5958/0974-360X.2018.00932.0
27. Shah CP, Joshi VJ, Patel DM, Dhami PD, Bhavsar DK, Trivedi MN, et al. Evaluation of in vitro antibacterial activity of roots of Glycyrrhiza glabra against multidrug resistant bacterial pathogens of E. coli. Res J Pharm Technol. 2011; 4(4).
28. Patel A, Kushwah P, Pillai S, Raghuvanshi A, Deshmukh N. Formulation and evaluation of herbal hand wash containing ethanolic extract of Glycyrrhiza glabra root extract. Res J Pharm Technol. 2017; 10(1). DOI: https://doi.org/10.5958/0974-360X.2017.00013.0
29. Kavya R. Glycyrrhiza glabra- an ayurvedic medicine in dentistry. Vol. 7, Research Journal of Pharmacy and Technology. 2014.
30. Londhe SS, Bhosale angesh G, Joshi AA. Formulation and evaluation of skin whitening- lightening herbal facewash. Asian Journal of Pharmacy and Technology. 2020; 10(4). DOI: https://doi.org/10.5958/2231-5713.2020.00041.0
31. Dambur AMR, Malluka R, Anton N, Kursia S. Formulation and Physical Stability Test of Lyophilisate Anti-acne Gel from Cocoon Waste from Soppeng Regency. Pharmacy Medical Journal (PMJ). 2019; 2(2): 70.
32. Noor SU, Faridah, Magdalena P. In-Vitro Tyrosinase Enzyme Inhibition Activity Test of Licorice Root (Glycyrrhiza glabra L.) Extract Cream. Journal of Indonesian Pharmaceutical Sciences. 2018; 16(2): 150–8. DOI: https://doi.org/10.35814/jifi.v16i2.566
33. Naiu AS, Yusuf N. Sensory Value and Viscosity Skin Cream uses Tuna Bone Gelatin as an Emulsifier and Humectant. J Processing of Indonesian Fishery Products. 2018; 21(2): 199. https//journal.ipb.ac.id/index.php/jphpi
34. Ameliana L, Wisudyaningsih B, Nurahmanto D, Dianatri YAM. Essence Development from Secang Wood Extract (Caesalpinia sappan L.). Journal of Indonesian Pharmaceutical Sciences. 2022; 20(1): 101–6. DOI: https://doi.org/10.35814/jifi.v20i1.1139
35. Hairunnisa H, Kartikasari D, Rahman IR, Kurnianto E. Formulation of serum ethanol extract of tampoi fruit rind (Baccaurea macrocarpa) as an antioxidant. Pharmacy Scientific Journal. 2022; 9(2): 11–23. DOI: https://doi.org/10.52161/jiphar.v9i2.411
36. Lasut TM, Tiwow G, Tumbel S, Karundeng E. Physical Stability Test of Ethanol Extract Ointment of Jackfruit Leaves Artocarpus heterophyllus Lamk. Tropical Biopharmaceuticals. 2019; 2(1): 63–70.
37. Hidayat S, Ummas Genisa M, Haryati Yuliany E. The utilization of moringa leaves extract (Moringa oleifera lamk.) As the tyrosinase inhibitor of human pigmentation. 2020; (1): 1–6.
38. Butool F, Rekha C, Rao AG. Clinical Study on Serum Zinc Levels in Patients with Acne Vulgaris. Asian J Research Chem. 2013; 6(May). https://www.indianjournals.com/ijor.aspx?target=ijor:ajrc&volume=6&issue=5&article=006