Author(s):
Pruthviraj K. Chaudhary, Satish A. Patel, Laxman M. Prajapati
Email(s):
pruthvichysspc@gmail.com
DOI:
10.52711/0974-360X.2024.00657 
Address:
Pruthviraj K. Chaudhary1*, Satish A. Patel1, Laxman M. Prajapati2
1Ganpat University – Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat Vidhyanagar - 384012, Mehsana - Gozaria Highway, North Gujarat, India.
2Shri Sarvajanik Pharmacy College, Mehsana, 384001, Gujarat, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 9,
Year - 2024
ABSTRACT:
Recent research has indicated a potential connection between low levels of 25-hydroxyvitamin D and dyslipidemia. This study aimed to explore this association among individuals from North Gujarat, India, undergoing routine health check-ups. The retrospective observational analysis included 1109 adults, focusing on their lipid profiles and serum 25(OH)D levels. Deficiency was defined as serum 25(OH)D < 30ng/ml. Results showed that 56% of participants had abnormal lipid levels, primarily involving LDL cholesterol. Interestingly, no considerable correlation was found between 25-hydroxyvitamin D levels and increased total cholesterol or triglycerides. The study underscores the need for extensive, multicenter east to west studies to provide clearer insights into this relationship within the Indian population.
Cite this article:
Pruthviraj K. Chaudhary, Satish A. Patel, Laxman M. Prajapati. Research Journal of Pharmacy and Technology. 2024; 17(9):4253-6. doi: 10.52711/0974-360X.2024.00657
Cite(Electronic):
Pruthviraj K. Chaudhary, Satish A. Patel, Laxman M. Prajapati. Research Journal of Pharmacy and Technology. 2024; 17(9):4253-6. doi: 10.52711/0974-360X.2024.00657 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-9-18
REFERENCES:
1. Holick MF. Vitamin D: evolutionary, physiological and health perspectives. Current Drug Targets. 2011; 12(1): 4-18. doi: 10.2174/138945011793591635.
2. Wranicz J, Szostak-Wegierek D. Health outcomes of vitamin D. Part I. Characteristics and classic role. Rocz Panstw Zakl Hig. 2014; 65(3): 179-84. doi: Not Available.
3. Shwetha M. N, Nancy Chandra Priya. P. Knowledge regarding vitamin D deficiency among students. Asian J. Nursing Education and Research. 2019; 9(1): 66-68. doi: 10.5958/2349-2996.2019.00013.2.
4. Ainur Amanzholkyzy, Roza E. Nurgaliyeva, Aiman T. Kaldybayeva, Tamara Zh. Batyrova, Farida K. Balmaganbetova, Zhuldyz A. Aibassova. Biochemical variability of Vitamin D Receptor (Vdr) Gene and its Relationship with Bone Mineral Density in Children of the Western Region of the Republic of Kazakhstan. Research J. Pharm. and Tech. 2019; 12(2): 735-740. 10.5958/0974-360X.2019.00130.6.
5. Subashree R., RadhikaArjunkumar. Vitamin D Deficiency in Periodontal Health. Research J. Pharm. and Tech. 2014; 7(2): 248-252.
6. Nawazish Alam, Om Prakash Agrawal, Rimpi, Perwez Alam, Satish Agrawal, Mukul Kaushik, J.S Dhari, Om Prakash Sharma. Natural Immunoenhancers. Research J. Pharm. and Tech. 2011; 4(10):1526-32.
7. R. Arivuchudar, Tamilchudar R. An Overview on the Sway of Nutritional Supplements on Dry Eye Disease. Research J. Pharm. and Tech. 2020; 13(10): 5004-8. doi: 10.5958/0974-360X.2020.00876.8.
8. Vinod Kumar Mugada, Raj KiranKolkota, SaiSrinivas KMS, Abdul Rasheed. Effectiveness of Oral Nano-particle based Vitamin D Solution in Pain Management: A Prospective Cross-sectional study. Research J. Pharm. and Tech. 2021; 14(1): 6-10. doi: 10.5958/0974-360X.2021.00002.0.
9. Ajay Choudhary, Rajesh Sharma, Ashok Kumar, KuldeepKinja, Ravi Berwal, Swapnil Sharma. Prevalence of 25-Hydroxyvitamin D Deficiency and its severity correlation with Acute Traumatic brain Injury in Indian Patients: A Perspective Observation Study. Research J. Pharm. and Tech. 2021; 14(7): 3874-8. doi: 10.52711/0974-360X.2021.00672.
10. Zhang Y, Song X, Jiang L, Wu J, Chen G, Chai J, Zheng X, Pei L. Association between vitamin D deficiency and Toxoplasma gondii infection in women of childbearing age. Wei Sheng Yan Jiu. 2020; 49(3): 368-73.
11. Suha A. AL-Fakhar, Wifaq M. Ali, Khalil Ismail A. Mohammed, Saad Hasan Mohammed Ali, Jinan M. Mousa, Israa Qasim Hussein. Correlation between Toxoplasmosis and Vitamin D Deficiency in women. Research J. Pharm. and Tech. 2022; 15(9): 4073-7. doi: 10.52711/0974-360X.2022.00683.
12. Mehwish Majeed, Shaheena Rasool, Tauseef Nazir, Mohd. Adil. The effect of vitamin D and Physical exercise on glycaemic control in patients with Type 2 Diabetes Mellitus(DM).Research J. Pharm. and Tech. 2022; 15(10): 4697-0. doi: 10.52711/0974-360X.2022.00788.
13. Lee JH, O'Keefe JH, Bell D, Hensrud DD, Holick MF. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor? J. Am. Coll. Cardiol. 2008; 52(24): 1949-56. doi: 10.1016/j.jacc.2008.08.050.
14. Tangpricha V., Pearce E.N., Chen T.C., Holick M.F. Vitamin D insufficiency among free-living healthy young adults. Am J Med. 2002; 112(8): 659-62.
15. Johnson MD, Nader NS, Weaver AL, Singh R, Kumar S. Relationships between 25-hydroxyvitamin D levels and plasma glucose and lipid levels in pediatric outpatients. J. Pediatr. 2010; 156(3): 444-9. doi: 10.1016/j.jpeds.2009.09.070.
16. Polkowska A, Głowińska-Olszewska B, Tobiaszewska M, Bossowski A. Risk factors for cardiovascular disease in children with type 1 diabetes in 2000-2010 in Podlasie Province. Pediatr Endocrinol. Diabetes Metab. 2015; 20(2): 47-54. doi: 10.18544/PEDM-20.02.0002.
17. Potenza MV, Mechanick JI. The metabolic syndrome: Definition, global impact, and pathophysiology. Nutr. ClinPract. 2009; 24(5): 560-77. doi: 10.1177/0884533609342436.
18. Jorde R, Figenschau Y, Hutchinson M, Emaus N, Grimnes G. High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. Eur. J. Clin. Nutr. 2010; 64(12): 1457-64. doi: 10.1038/ejcn.2010.176.
19. Lupton JR, Faridi KF, Martin SS, Sharma S, Kulkarni K, Jones SR, Michos ED. Deficient serum 25-hydroxyvitamin D is associated with an atherogenic lipid profile: The Very Large Database of Lipids (VLDL-3) study. J. Clin. Lipidol. 2016; 10(1): 72-81. doi: 10.1016/j.jacl.2015.09.006.
20. Ponda MP, Huang X, Odeh MA, Breslow JL, Kaufman HW. Vitamin D may not improve lipid levels: a serial clinical laboratory data study. Circulation. 2012; 17; 126(3): 270-7. doi: 10.1161/CIRCULATIONAHA.111.077875.
21. Al Mheid I, Quyyumi AA. Vitamin D and Cardiovascular Disease: Controversy Unresolved. J. Am.Coll.Cardiol. 2017; 70(1): 89-100. doi: 10.1016/j.jacc.2017.05.031.
22. Hiemstra TF, Lim K, Thadhani R, Manson JE.. Vitamin D and atherosclerotic cardiovascular disease. J Clin. Endocrinol. Metab. 2019; 104(9): 4033–4050. doi: 10.1210/jc.2019-00194.
23. Pilz S, Verheyen N, Grübler MR, Tomaschitz A, März W. Vitamin D and cardiovascular disease prevention. Nat. Rev. Cardiol. 2016; 13(7): 404-17. doi: 10.1038/nrcardio.2016.73.
24. Chaudhuri JR, Mridula KR, Anamika A, Boddu DB, Misra PK, Lingaiah A, et al. Deficiency of 25-hydroxyvitamin d and dyslipidemia in Indian subjects. J. Lipids. 2013; 2013(Dec): 1-7. doi:10.1155/2013/623420.
25. Jorde R, Figenschau Y, Hutchinson M, Emaus N, Grimnes G. High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. Eur. J. Clin. Nutr. 2010; 64(12): 1457-64. doi: 10.1038/ejcn.2010.176.
26. Vieth R, Bischoff-Ferrari H, Boucher BJ, Dawson-Hughes B, Garland CF, Heaney RP, Holick MF, Hollis BW, Lamberg-Allardt C, McGrath JJ, Norman AW, Scragg R, Whiting SJ, Willett WC, Zittermann A. The urgent need to recommend an intake of vitamin D that is effective. Am. J. Clin. Nutr. 2007; 85(3): 649-50. doi: 10.1080/07315724.
27. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001; 285(19): 2486-97.
28. IBM Corp. Released 2011. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp.
29. Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl DA, Pierroz DD, Weber P, Hoffmann K. A systematic review of vitamin D status in populations worldwide. Br. J. Nutr. 2014; 111(1): 23-45. doi:10.1017/S0007114513001840.
30. Herrick KA, Storandt RJ, Afful J, Pfeiffer CM, Schleicher RL, Gahche JJ, Potischman N. Vitamin D status in the United States, 2011-2014. Am. J. Clin. Nutr. 2019; 110(1): 150-157. doi: 10.1093/ajcn/nqz037.
31. Lips P, Cashman KD, Lamberg-Allardt C, Bischoff-Ferrari HA, Obermayer-Pietsch B, Bianchi ML, Stepan J, et al. Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society. Eur J Endocrinol. 2019; 180(4): P23-P54. doi: 10.1530/EJE-18-0736.
32. Zhang W, Stoecklin E, Eggersdorfer M. A glimpse of vitamin D status in Mainland China. Nutrition. 2013; (7-8): 953-7. doi: 10.1016/j.nut.2013.01.010.
33. Bhavani Anantharamakrishnan, JishaBenansia. Association between vitamin D level and serum lipid parameters among Indian adults working in it sector: a retrospective observationalstudy. 2020 Oct. doi: https://doi.org/10.1101/20 20.10.20.20215624. Available from:https://www.medrxiv.org/content/10.1101/ 2020.10.20.20215624v1.full.pdf.
34. Debdoot Basu, Anant Yadav, Anita A. Mehta. Effect of Vitamin D Supplementation in patients with Cardiometabolic disorders- A Clinical Study in Ahmedabad population. Research J. Pharm. and Tech. 2022; 15(4): 1517-2. doi: 10.52711/0974-360X.2022.00252.
35. Banerjee R, Datta S, Rout AJ. Correlation of vitamin D status with lipid profile of outpatient department attendees: a cross sectional study in a rural tertiary care hospital of North Bengal, India. J. Evolution Med. Dent. Sci. 202; 10(35): 3012-3016. doi: 10.14260/jemds/2021/615.
36. Gaddipati VC, Bailey BA, Kuriacose R, Copeland RJ, Manning T, Peiris AN. The relationship of vitamin D status to cardiovascular risk factors and amputation risk in veterans with peripheral arterial disease. J. Am. Med. Dir. Assoc. 2011; 12(1): 58-61. doi: 10.1016/j.jamda.2010.02.006.
37. Jungert A, Roth HJ, Neuhäuser-Berthold M. Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status. Public Health Nutr. 2015; 18(9): 1684-91. doi: 10.1017/S1368980014002286.
38. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am. J. Clin. Nutr. 2004; 79(5): 820-5. doi:10.1093/ajcn/79.5.820.
39. John WG, Noonan K, Mannan N, Boucher BJ. Hypovitaminosis D is associated with reductions in serum apolipoprotein A-I but not with fasting lipids in British Bangladeshis. Am. J. Clin. Nutr. 2005; 82(3): 517-22. doi: 10.1093/ajcn.82.3.517.