Author(s):
Manorama Ratre, Ritesh Jain, Dheeraj Ahirwar, Hemlata Rathore, Geetanjali Sahu, Bharti Ahirwar, Suresh Kumar Sahu
Email(s):
mannoratre94@gmail.com
DOI:
10.52711/0974-360X.2024.00650 
Address:
Manorama Ratre1*, Ritesh Jain1, Dheeraj Ahirwar1, Hemlata Rathore1, Geetanjali Sahu1, Bharti Ahirwar2, Suresh Kumar Sahu3
1School of Pharmacy, Chouksey Engineering College, Bilaspur, Chhattisgarh - 495001, India.
2SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur, Chhattisgarh - 495009, India.
3Mark Hospital, Bilaspur, Chhattisgarh - 495006, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 9,
Year - 2024
ABSTRACT:
The COVID-19 pandemic has spurred global efforts to identify effective therapeutic strategies. One promising avenue involves exploration of bioactive metabolites as potential inhibitors of main protease enzyme (Mpro) of SARS-CoV-2 virus. Mpro plays a critical role in viral replication and is considered a prime target for drug development.This review delves in potential of bioactive metabolites in managing COVID-19 by inhibiting Mpro. Bioactive metabolites are naturally occurring compounds found in various organisms, including plants, fungi, and marine life, known for their diverse biological activities. They have shown promise in inhibiting enzymatic activity of Mpro, disrupt viral replication-mitigate infection. This study explores a wide range of bioactive, sources, and inhibitory effects on Mpro. It investigates mechanisms of action and binding affinities of these metabolites, shedding light on their potential as anti-COVID-19 agents. Moreover, the review discusses the development of bioactive metabolite-based drugs and their safety and efficacy in COVID-19 management. By elucidating the potential of metabolites in inhibiting Mpro, this review contributes to the development of novel therapeutic interventions for COVID-19, offering hope in the battle against ongoing pandemic. These findings may pave the way for development of effective treatments that can complement existing strategies in the fight against SARS-CoV-2.
Cite this article:
Manorama Ratre, Ritesh Jain, Dheeraj Ahirwar, Hemlata Rathore, Geetanjali Sahu, Bharti Ahirwar, Suresh Kumar Sahu. Exploring the Potential of Bioactive Metabolites in COVID-19 Management through main Protease Enzyme (MPRO) Inhibition. Research Journal of Pharmacy and Technology. 2024; 17(9):4203-3. doi: 10.52711/0974-360X.2024.00650
Cite(Electronic):
Manorama Ratre, Ritesh Jain, Dheeraj Ahirwar, Hemlata Rathore, Geetanjali Sahu, Bharti Ahirwar, Suresh Kumar Sahu. Exploring the Potential of Bioactive Metabolites in COVID-19 Management through main Protease Enzyme (MPRO) Inhibition. Research Journal of Pharmacy and Technology. 2024; 17(9):4203-3. doi: 10.52711/0974-360X.2024.00650 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-9-11
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