Author(s):
Monika Puri, Yogesh Kumar Walia
Email(s):
monikapuri20022008@gmail.com
DOI:
10.52711/0974-360X.2024.00615 
Address:
Monika Puri1, Yogesh Kumar Walia2
1Research Scholar, Career Point University, Hamirpur (H.P.), India.
2Professor, Department of Chemistry, Career Point University, Hamirpur (H.P.), India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 8,
Year - 2024
ABSTRACT:
A precise, sensitive, and focused liquid chromatographic method has been developed to assess the quantity of aspirin in its bulk form. The chromatographic conditions involved utilizing a C-18 column (250 x 4.6 mm, 5 µm particle size) with a mobile phase consisting of water containing 0.1% orthophosphoric acid (v/v) at pH 3.0 and acetonitrile in a ratio of 45:55. The flow rate was set at 1 ml per minute, and the total run time was 20 minutes, with a detection wavelength of 237 nm. The retention time was observed to be 4.01 minutes, and the method exhibited an average recovery percentage of 99.9%. The proposed procedure adhered to the guidelines established by the ICH and is applicable for analyzing aspirin as a standalone bulk drug and in combination with other pharmaceuticals.
Cite this article:
Monika Puri, Yogesh Kumar Walia. Analysis of Aspirin (Acetylsalicylic Acid): Development and Validation using RP-HPLC Methods - A Component of Anti-hypertensive Drugs. Research Journal of Pharmacy and Technology.2024; 17(8):3963-8. doi: 10.52711/0974-360X.2024.00615
Cite(Electronic):
Monika Puri, Yogesh Kumar Walia. Analysis of Aspirin (Acetylsalicylic Acid): Development and Validation using RP-HPLC Methods - A Component of Anti-hypertensive Drugs. Research Journal of Pharmacy and Technology.2024; 17(8):3963-8. doi: 10.52711/0974-360X.2024.00615 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-8-63
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