Author(s):
Vyankatesh Dharanguttikar, Vijay Salunkhe, Swapnali Dharanguttikar
Email(s):
vyankat87@gmail.com
DOI:
10.52711/0974-360X.2024.00614 
Address:
Vyankatesh Dharanguttikar1*, Vijay Salunkhe1, Swapnali Dharanguttikar2
1Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Taluka - Walwa, District - Sangli, Pin Code - 415404, Maharashtra, India.
2Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Near Chitranagri, Kolhapur, Pin Code – 416013, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 8,
Year - 2024
ABSTRACT:
The process of wound recovery is a complex challenge, wherein the skin and the underlying tissue undergo self-repair following an injury. Wound healing comprises four fundamental stages: haemostasis, inflammation, proliferation, and maturation. The leaves of Terminalia bellerica are widely employed in traditional Indian medicine for the treatment of wounds. Terminalia bellerica contains a variety of chemical constituents, including alkaloids, flavonoids, terpenoids, phenols, tannins, saponins, glycosides, sterols, amino acids, and reducing sugars such as ribose, glucose, lactose, maltose, and sucrose. This study specifically addresses the composition of Terminalia bellerica, focusing particularly on its Herbosomal formulation with potential in wound healing, along with a method for preparing a transdermal patch. Over a 16-day period, a transdermal patch (incorporating F5 composition) demonstrated a reduction in the wound area across different animal groups. Consequently, the formulation (containing F5 composition) expeditiously promotes wound healing (epithelialization time 15.52–16.21 days) and exhibits substantial similarity to the group treated with 5% povidone–iodine ointment. In comparison to existing technology, the transdermal patch (F5 composition with only 50mg of the drug) achieved complete healing in 16.86±3.22 days with 96.10±2.88% wound contraction. The results highlight a significant enhancement in bioavailability and specific wound healing activity for the prepared formulation.
Cite this article:
Vyankatesh Dharanguttikar, Vijay Salunkhe, Swapnali Dharanguttikar. Enhancing Wound Healing Potential through the Development of a Herbosomal Transdermal Patch Containing Terminalia bellerica Ethanolic Extract. Research Journal of Pharmacy and Technology.2024; 17(8):3955-2. doi: 10.52711/0974-360X.2024.00614
Cite(Electronic):
Vyankatesh Dharanguttikar, Vijay Salunkhe, Swapnali Dharanguttikar. Enhancing Wound Healing Potential through the Development of a Herbosomal Transdermal Patch Containing Terminalia bellerica Ethanolic Extract. Research Journal of Pharmacy and Technology.2024; 17(8):3955-2. doi: 10.52711/0974-360X.2024.00614 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-8-62
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