Author(s):
Ahmed Farid Elshazly, Ahmed Abdelkader Eltabakh, Mohamed IBRAHIM Abdelkader Elbarbary, Ahmed Salah Ahmed El beltagy, Samir Khamis Galal, Emad Mohamed Ibrahim Atallah2, Abdel-Monsef Abdel-Ghaffar Moustafa2, Nawal Hamdy Ahmed Keshta, Hanan Barakat Abu Elyazid Shatat, Mahmoud Sedki Yassin Ali, Maged Salah eldien elkady, Omar Nagy, Ali Elsayed Khayal, Kareem El-Nahhas, Marwa Yahia Mahmoud
Email(s):
ahmedstakh@protonmail.com
DOI:
10.52711/0974-360X.2024.00609 
Address:
Ahmed Farid Elshazly1, Ahmed Abdelkader Eltabakh2, Mohamed IBRAHIM Abdelkader Elbarbary2, Ahmed Salah Ahmed El beltagy2, Samir Khamis Galal2, Emad Mohamed Ibrahim Atallah2, Abdel-Monsef Abdel-Ghaffar Moustafa2, Nawal Hamdy Ahmed Keshta3, Hanan Barakat Abu Elyazid Shatat3, Mahmoud Sedki Yassin Ali4, Maged Salah eldien elkady1, Omar Nagy5, Ali Elsayed Khayal6, Kareem El-Nahhas5, Marwa Yahia Mahmoud7
1Lecturer of Obstetrics and Gynecology, At Misr University for Science and Technology Must University, Egypt.
2Department of Obstetrics and Gynecology, Faculty of Medicine, Al Azhar University, Cairo, Egypt.
3Department of Obstetrics and Gynecology, Faculty of Medicine, Al Azhar University, Girls Branch, Cairo, Egypt.
4Department of Obstetrics and Gynecology at General Organization for Teaching Hospitals and Institutes, Banha Teaching Hospital, Banha, Egypt.
5Department of Reproductive Health and Family Planning, Medical Research and Clinical Studies Institute, National Research Cen
Published In:
Volume - 17,
Issue - 8,
Year - 2024
ABSTRACT:
Objective: The aim of our paper to found the role of the anti-mullerian hormone (AMH) before and after laparoscopic excision of benign ovarian tumors. Methods: This was a prospective study performed at a tertiary medical center. We included a number of sixty-five patients, aged 18 to 44 years old, to perform laparoscopic cystectomy on patients with benign ovarian tumors after ultrasound evaluation and histopathological confirmation. We measured of this study were to study the change in the level of the AMH after excision of benign ovarian tumors and the effect of age, cyst size, operation time, and histopathological subtype on the percent of change in the AMH level. Results: We detected a significant reduction in the AMH level after ovarian cystectomy. According to our analysis, there was a group variation based on the histopathological type of the mass but not according to age, cyst size, laterality, or operation time. A direct relationship was seen between the pre-operative AMH level and its level post-operatively, as well as after three months of follow-up. Conclusions: Our study shows a significant reduction in the level of the AMH after laparoscopic surgery to benign ovarian masses. In order to study the change in the level of the AMH after benign ovarian tumor excision, future studies should include more patients for a lengthy follow-up period.
Cite this article:
Ahmed Farid Elshazly, Ahmed Abdelkader Eltabakh, Mohamed IBRAHIM Abdelkader Elbarbary, Ahmed Salah Ahmed El beltagy, Samir Khamis Galal, Emad Mohamed Ibrahim Atallah2, Abdel-Monsef Abdel-Ghaffar Moustafa2, Nawal Hamdy Ahmed Keshta, Hanan Barakat Abu Elyazid Shatat, Mahmoud Sedki Yassin Ali, Maged Salah eldien elkady, Omar Nagy, Ali Elsayed Khayal, Kareem El-Nahhas, Marwa Yahia Mahmoud. Serum Level of Anti-Mullerian Hormone Before and After Surgical Operations for Ovarian Tumors: A Prospective Study. Research Journal of Pharmacy and Technology. 2024; 17(8):3929-2. doi: 10.52711/0974-360X.2024.00609
Cite(Electronic):
Ahmed Farid Elshazly, Ahmed Abdelkader Eltabakh, Mohamed IBRAHIM Abdelkader Elbarbary, Ahmed Salah Ahmed El beltagy, Samir Khamis Galal, Emad Mohamed Ibrahim Atallah2, Abdel-Monsef Abdel-Ghaffar Moustafa2, Nawal Hamdy Ahmed Keshta, Hanan Barakat Abu Elyazid Shatat, Mahmoud Sedki Yassin Ali, Maged Salah eldien elkady, Omar Nagy, Ali Elsayed Khayal, Kareem El-Nahhas, Marwa Yahia Mahmoud. Serum Level of Anti-Mullerian Hormone Before and After Surgical Operations for Ovarian Tumors: A Prospective Study. Research Journal of Pharmacy and Technology. 2024; 17(8):3929-2. doi: 10.52711/0974-360X.2024.00609 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-8-57
REFERENCES:
1. Westhoff C, Clark CJG. Benign ovarian cysts in England and Wales and in the United States. BJOG. 1992; 99(4): 329-332. doi:10.1111/j.1471-0528.1992.tb13733.x
2. Velebil P, Wingo P, Xia Z, Wilcox L, Peterson H. Rate of hospitalization for gynecologic disorders among reproductive-age women in the United States. Obstetrics and Gynecology. 1995; 86(5): 764-769. doi:10.1016/0029-7844(95)00252-M
3. Canis M, Mage G, Wattiez A, Pouly JK, Sonteara SS, Bruhat MA. A simple management program for adnexal masses. Ref Gynecol Obstet . 2000; 77: 563-565.
4. Sassone AM, Timor-Tritsch IE, Artner A, Westhoff C, Warren WB. Transvaginal sonographic characterization of ovarian disease: evaluation of a new scoring system to predict ovarian malignancy. Obstetrics and Gynecology. 1991; 78(1): 70-76.
5. Brown DL, Frates MC, Laing FC, et al. Ovarian masses: can benign and malignant lesions be differentiated with color and pulsed Doppler US? Radiology. 1994; 190(2): 333-336. doi:10.1148/radiology.190.2.8284377
6. Chou CY, Chang CH, Yao BL, Kuo HC. Color Doppler ultrasonography and serum CA 125 in the differentiation of benign and malignant ovarian tumors. J Clin Ultrasound. 1994; 22(8):4 91-496. doi:10.1002/jcu.1870220806
7. Grammatikakis I, Trompoukis P, Zervoudis S, et al. Laparoscopic Treatment of 1522 Adnexal Masses: An 8-Year Experience. Diagn Ther Endosc. 2015; 2015: 1-3. doi:10.1155/2015/979162
8. Canis M, Mage G, Pouly JL, Wattiez A, Manhes H, Bruhat MA. Laparoscopic diagnosis of adnexal cystic masses: a 12-year experience with long-term follow-up. Obstetrics and Gynecology. 1994; 83(5 Pt 1): 707-712.
9. Lundorff P, Hahlin M, Källfelt B, Thorburn J, Lindblom B. Adhesion formation after laparoscopic surgery in tubal pregnancy: a randomized trial versus laparotomy. Fertil Steril. 1991; 55(5): 911-915. doi:10.1016/S0015-0282(16)54298-8
10. Chen Y, Pei H, Chang Y, et al. The impact of endometrioma and laparoscopic cystectomy on ovarian reserve and the exploration of related factors assessed by serum anti-Mullerian hormone: a prospective cohort study. J Ovarian Res. 2014; 7(1): 108. doi:10.1186/s13048-014-0108-0
11. Kwon SK, Kim SH, Yun SC, et al. Decline of serum antimüllerian hormone levels after laparoscopic ovarian cystectomy in endometrioma and other benign cysts: a prospective cohort study. Fertil Steril. 2014; 101(2): 435-441. doi:10.1016/j.fertnstert.2013.10.043
12. Mohamed AA, Al-Hussaini TK, Fathalla MM, El Shamy TT, Abdelaal II, Amer SA. The impact of excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review. Am J Obstet Gynecol. 2016; 215(2): 169-176. doi:10.1016/j.ajog.2016.03.045.
13. IE Otuokere, FJ Amaku. Conformational analysis and excited – state properties of a highly potent and totally selective aromatase inhibitor, 4,4'-(1H-1,2,4-triazol-1-ylmethanediyl) dibenzo nitrile (letrozole). Research Journal of Pharmacology and Pharmacodynamics. 2015; 7(4): 176-180.
14. Swati B. Pokale, Ghanshayam Jadhav. Piper longum (Linn.) restores ovarian function in Letrozole induced PCOS in Rats: Comparison with Metformin and Clomiphene citrate. Research Journal of Pharmacy and Technology. 2021; 14(10): 5190-6.
15. Devadasu C.H., Harika S., Mallikarjuna T., Adilakshmi G., Sreenath A., Swetha Ratna G. A Spectrophotometric Assay for the Simultaneous Analysis of Mifepristone and Misoprostol in Tablets Using Vierodt’s and Absorbance Ratio Methods. Research J. Pharm. and Tech. 2012; Jan. 5(1): 46-49.
16. N. Sravanthi, K. Alekhya, S. Punitha. Formulation and Process Scale up of Misoprostol Tablets. Research J. Pharm. and Tech. 2011; 4(11): Nov. 1673-1675.
17. Maysoon Khudair. AL-Hadrawi, Ahmed Abdul Hasan Mohsin, Kais K.AL- Hadrawai, Noor Ismeal Nasser, Ali k. Metiab. Study the predictable correlation between recurrent abortion with the level of proteins S, C, age, and blood groups in women in AL-Najaf governorate, Iraq. Research Journal of Pharmacy and Technology. 2022; 15(7): 3200-4.
18. N. Sravanthi, K. Alekhya, S. Punitha. Formulation and Process Scale up of Misoprostol Tablets. Research J. Pharm. and Tech. 2011; Nov. 4(11): 1673-1675.
19. Mary Lucita (Agasa. K. S). A Study of the Socio-Demographic and Maternal Factors Affecting Spontaneous Abortion. Int. J. Adv. Nur. Management. 2014; July-Sept., 2(3): 159-161.
20. Samrithi Yuvaraj, A. Jothi Priya, Nirisha Sriram. Effect of Non Steroidal Anti Inflammatory Drugs in Pregnancy: A Systematic Review. Research J. Pharm. and Tech. 2015; June, 8(6): 787-791.
21. Muhammed A. H. Aldabagh. Immune Profile in Iraqi women with Recurrent Spontaneous Abortion (RSA) Proved with Cytomegalovirus Infection (CMV). Research J. Pharm. and Tech. 2018; 11(2): 599-603.
22. Hussein O. Al-Dahmoshi, Mourouge S. Alwash, Sura I. Chabuck, Noor S. Al-Khafaji, Susan I. Jabuk. Antimicrobial Susceptibility Patterns of Genital Mycoplasma Infections in Pregnancy and Spontaneous Abortion. Research J. Pharm. and Tech. 2019; 12(12): 6198-6202.