Author(s):
Saad Touqeer, Sulayman Abid, Muhammad Asad Saeed, Umair Ikram Dar
Email(s):
saad.touqeer@aau.ac.ae
DOI:
10.52711/0974-360X.2024.00570 
Address:
Saad Touqeer1,2*, Sulayman Abid3, Muhammad Asad Saeed4, Umair Ikram Dar5
1College of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 112612, United Arab Emirates.
2AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi P.O. Box 112612, United Arab Emirates.
3Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.
4Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan.
5Lahore College of Pharmaceutical Sciences, Lahore, Pakistan.
*Corresponding Author
Published In:
Volume - 17,
Issue - 8,
Year - 2024
ABSTRACT:
An extensive study was conducted on the methanolic extracts of two plants namely, Breynia disticha and Vernonia elaeagnifolia aiming to identify their antipyretic, hypoglycemic and irritant activities. Antipyretic effect was studied using milk induced pyrexia in rabbits whereas hypoglycemic effect was studied using glibenclamide as a standard drug in rabbits. In case of both studies the results were found to be significant (P<0.05). No irritant effect was observed on the rabbit’s ear. The studies show the plants to be of wide and significant medicinal importance.
Cite this article:
Saad Touqeer, Sulayman Abid, Muhammad Asad Saeed, Umair Ikram Dar. Antipyretic, Antidiabetic and Irritant studies on the Methanolic Extracts and Polyherbal Mixture of Breynia disticha J.R. Forst. and G. Forst. and Vernonia elaeagnifolia DC. Research Journal of Pharmacy and Technology. 2024; 17(8):3658-2. doi: 10.52711/0974-360X.2024.00570
Cite(Electronic):
Saad Touqeer, Sulayman Abid, Muhammad Asad Saeed, Umair Ikram Dar. Antipyretic, Antidiabetic and Irritant studies on the Methanolic Extracts and Polyherbal Mixture of Breynia disticha J.R. Forst. and G. Forst. and Vernonia elaeagnifolia DC. Research Journal of Pharmacy and Technology. 2024; 17(8):3658-2. doi: 10.52711/0974-360X.2024.00570 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-8-18
REFERENCE:
1. Banday MZ, Sameer AS, Nissar S. Pathophysiology of diabetes: An overview. Avicenna Journal of Medicine. 2020; 10: 174-88. doi: 10.4103/ajm.ajm_53_20
2. Misra A, Gopalan H, Jayawardena R, Hills AP, Soares M, Reza‐Albarran AA, Ramaiya KL. Diabetes in developing countries. Journal of diabetes. 2019; 11(7): 522-539. doi:10.1111/1753-0407.12913
3. Panchal I, Panigrahi B, Patel CN. Recent Advancement towards Treatment of Diabetes. Research Journal Pharmacology and Pharmacodynamics. 2010; 2 (1): 12-22.
4. Preethi PJ. Herbal Medicine for Diabetes Mellitus: A Review. Asian Journal of Pharmaceutical Research. 2013; 3 (2): 57-70.
5. Jha AK, Verma P, Prasad M, Sachan NK, Gautam K. Alternative Medicine: An Introduction and Market Potential. Research Journal Pharmacognosy and Phytochemistry. 2009; 1(3): 146-152.
6. Sharma S, Sharma R, Singh H, Nelkumar B. History of Medicine – Herbal Medicine Scenario: A Review. Research Journal Pharmacology and Pharmacodynamics. 2011; 3 (2): 45-47.
7. Jadhav CA, Vikhe DN, Jadhav RS. Global and Domestic Market of Herbal Medicines: A Review. Research Journal of Science and Technology. 2020; 12(4): 327-330. doi: 10.5958/2349-2988.2020.00049.2
8. Cock IE, Luwaca N, Van Vuuren SF. The traditional use of Southern African medicinal plants to alleviate fever and their antipyretic activities. Journal of Ethnopharmacology. 2023; 303: 115850-61. doi: 10.1016/j.jep.2022.115850
9. Nilima T, Pranali S, Madhura T. Medicinal plant as a source of Antipyretic drug: A Review. Asian Journal of Pharmacy and Technology. 2021; 11(1): 84-87. doi: 10.5958/2231-5713.2021.00014.3
10. El-Banna H, Haroun SA, Albishi TS, Rashed AA, Albadrani M, Abdelaal K, Abdou AH. The Natural Alternatives: The Impact of Plant Extracts on Snowbush (Breynia disticha Forst.) Cuttings’ Morpho-Physiological and Biochemical Characteristics. Horticulturae. 2023; 9(10): 1122-1135. doi:10.3390/horticulturae9101122
11. Saadullah M, Asif M, Arif S, Kanwal B. A Comprehensive Review on Traditional Uses, Chemical Constituents, and Diverse Pharmacological Importance of the Genus Breynia. Records of Natural Products. 2022; 6: 538-549. doi: 10.25135/rnp.314.2112.2280
12. Nakashima KI, Abe N, Oyama M, Murata H, Inoue M. Sulfur-containing spiroketals from Breynia disticha and evaluations of their anti-inflammatory effect. Beilstein Journal of Organic Chemistry. 2023; 19(1): 1604-1614. doi: 10.3762/bjoc.19.117
13. Saadullah M, Asif M, Uzair M, Afzal S, Rashid SA, Rashad M, Mahmood S. Pharmacological evaluation of the hypoglycemic and anti-Alzheimer’s activities of aerial parts of Breynia distachia (Phyllanthaceae). Tropical Journal of Pharmaceutical Research. 2022; 21(3): 579-587. doi: 10.4314/tjpr.v21i3.18
14. Vongsombath C, De Boer HJ, Pålsson K. Keeping leeches at bay: Field evaluation of plant-derived extracts against terrestrial blood-sucking leeches (Haemadipsidae) in Lao PDR. Acta tropica. 2011; 119(2): 178-182. doi: 10.1016/j.actatropica.2011.05.014
15. NawaleS, Priyanka N, Das S, Raju MG. Data of in vivo screening of antiulcer activity for methanolic extract of Vernonia elaeagnifolia DC. Data in brief. 2019; 23: 103753. doi: 10.1016/j.dib.2019.103753
16. Acharzo AK, Rahman S, Anisuzzman M, Islam MA, Kundu P, Bokshi B, Billah M. Antihyperglycemic, Neuropharmacological, Cytotoxic, Anticoagulant, and Anti-inflammatory Pharmacological Evaluations of Vernonia elaeagnifolia DC Leaves Secondary Bioactive Metabolites. European Journal of Pharmaceutical Research. 2023; 3(4): 1-9. doi: 10.24018/ejpharma.2023.3.4.70
17. Sultana A, Khaliq T, Rehman AU, Majeed W, Faisal MN, Aslam B, Anwar H. Pharmacological evaluation of Vernonia elaeagnifolia (Asteraceae) leaves in hyperlipidemic albino rabbits. Tropical Journal of Pharmaceutical Research. 2017; 16(5): 1077-1083. doi; 10.4314/tjpr.v16i5.15
18. Hacker E. Methods of Cancer Research. Academic Press, London.1971.
19. Saeed-ul-Hassan S, Khalil-ur-Rehman M, Niaz U, Saeed MA., Hussain K, Rao SA, Ahmed I. Isolation and characterization of irritant components of Euphorbia pilulifera L. Pakistan Journal of Pharmaceutical Sciences. 2013; 26(1): 31-37.
20. Ahmed S, MaalikS, Zehra T, Baig SG, Zehra S. Preclinical assessment of analgesic, anti-inflammatory and antipyretic potential of Fragaria ananassa and Actinidia deliciosa fruit extract. Pakistan Journal of Pharmaceutical Sciences. 2021; 34(2): 521-527.
21. Sudasinghe HP, Peiris DC. Hypoglycemic and hypolipidemic activity of aqueous leaf extract of Passiflora suberosa L. PeerJ. 2018; 6: 4389. doi: 10.7717/peerj.4389
22. Kumbhare M, Sivakumar T, Surana A. Evaluation of Hypoglycemic potential of Moringa oleifera bark extracts on normal and Alloxanized diabetic rats. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13 (2): 95-9. doi: 10.52711/0975-4377.2021.00017
23. Shrivastava A, Parveen N, Dewangan G, Vinay VS, Bhattacharya A, Sharma M. Evaluation of Anti-Pyretic Potential of Cassia alata Leaves. Asian Journal of Pharmaceutical Research. 2014; 4 (4): 195-197.
24. Elumalai A, Eswaraiah MC, Lahari KM, Shaik HA. In-vivo screening of Bougainvillea glabra leaves for its Analgesic, Anti-pyretic and Anti-inflammatory activities. Asian Journal of Research in Pharmaceutical Science. 2012; 2 (3): 85-87.
25. Ghiwarem NB, Nesari TM. Antipyretic Activity of Piper nigrum and Nyctanthes arbor-tristis in Different Dosage Forms. Research Journal of Pharmacy and Technology. 2010; 3 (1): 157-160.
26. Quigley L, McCarthy R, O'Sullivan O, Beresford TP, Fitzgerald GF, Ross RP, Cotter PD. The microbial content of raw and pasteurized cow milk as determined by molecular approaches. Journal of Dairy Science. 2013; 96 (8): 4928-4937.