Author(s):
Aditya Singh, Vaseem Ahamad Ansari, Tarique Mahmood
Email(s):
vaseem9in@gmail.com
DOI:
10.52711/0974-360X.2024.00568 
Address:
Aditya Singh, Vaseem Ahamad Ansari, Tarique Mahmood
Department of Pharmacy, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh - 226026, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 8,
Year - 2024
ABSTRACT:
Ursolic acid (UA), a reversible cholinesterase inhibitor, shows promise in Alzheimer's disease (AD) treatment. This study aimed to develop a nanoparticulate drug delivery system using PAMAM G0 dendrimers for UA, targeting sustained release and enhanced brain targeting, and subjected to NMR and in silico analysis. This study utilized UA-loaded PAMAM dendrimers for in silico molecular docking studies to evaluate their potential against dementia. Using AutoDock software, the formulation was evaluated against dementia targets, including ß-amyloid fibril (PDB ID: 2ENS) and AGER ligands. The results showed that UA-loaded PAMAM dendrimers had a higher binding affinity (score: -8.5) compared to known UA inhibitors. This suggests that UA-loaded PAMAM dendrimers could effectively target key aspects of dementia, indicating potential for more effective dementia therapies. Further experimental validation is necessary to confirm these findings.
Cite this article:
Aditya Singh, Vaseem Ahamad Ansari, Tarique Mahmood. Development and Evaluation of Ursolic acid Loaded Dendrimers. Research Journal of Pharmacy and Technology. 2024; 17(8):3642-8. doi: 10.52711/0974-360X.2024.00568
Cite(Electronic):
Aditya Singh, Vaseem Ahamad Ansari, Tarique Mahmood. Development and Evaluation of Ursolic acid Loaded Dendrimers. Research Journal of Pharmacy and Technology. 2024; 17(8):3642-8. doi: 10.52711/0974-360X.2024.00568 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-8-16
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