Author(s): Shetty Chetan Kumar, Sheeba F R

Email(s): sheebapharmacy@gmail.com

DOI: 10.52711/0974-360X.2024.00467   

Address: Shetty Chetan Kumar, Sheeba F R*
Department of Pharmaceutics, Mallige College of Pharmacy, Silvepura, Chikkabanavara Post, Bengaluru - 560090.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
The floating drug delivery system (FDDS) is a promising gastro retentive drug system that offers advantages such as improved stomach retention and enhanced effectiveness of medicinal treatment. Over time, oral drug delivery systems have evolved from immediate release to delayed release, site-specific delivery, and sustained release, with the primary goal of enhancing bioavailability and predictability of drug action. One particular type of gastric retention system, the floating in-situ gelling system, has gained attention for its innovative drug delivery approach, leveraging the unique physiology of the stomach. This review study explores the preparation, materials, mechanism, and action of the floating in-situ gelling system within the stomach, highlighting important findings. Furthermore, it examines the efficacy of the system's mechanism. Currently, oral administration accounts for approximately half of the medication delivery systems available in the market, mainly due to its ease of use and high patient compliance. Among the various methods of oral drug administration, floating drug delivery systems have emerged as a focus of ongoing research and development efforts.


Cite this article:
Shetty Chetan Kumar, Sheeba F R. Stomach Specific Novel Floating In-situ Gel for Sustained Drug Delivery: Overview. Research Journal of Pharmacy and Technology. 2024; 17(6):2990-6. doi: 10.52711/0974-360X.2024.00467

Cite(Electronic):
Shetty Chetan Kumar, Sheeba F R. Stomach Specific Novel Floating In-situ Gel for Sustained Drug Delivery: Overview. Research Journal of Pharmacy and Technology. 2024; 17(6):2990-6. doi: 10.52711/0974-360X.2024.00467   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-86


REFERENCES:
1.    Shailaja Pashikanti, Jyothsna B. Formulation and Evaluation of In-Situ Gel of Ciprofloxacin. International Journal of Applied Pharmaceutics. 2019; 11(1): 198-204. doi: 10.22159/ijap.2019v11i1.28603
2.    Kailash Sahu et al. Formulation and Evaluation of Gastro Retentive Sustained Release Tablets of Ziprasidone Hydrochloride. Research Journal of Pharmacy and Technology. 2018; 11(5): https://doi.org/10.5958/0974-360X.2018.00386.4
3.    Harshvinder Singh et al. Formulation and Evaluation of Floating Tablets of Cimetidine. International Journal of ChemTech Research. 2018; 11(9): 383-92. doi: 10.20902/IJCTR.2018.110944
4.    Akelesh T et al. Formulation and Evaluation of Floating Effervescent Domperidine Tablets. Research Journal of Pharmacy and Technology. 2016; 9(12): 2169-79 doi: 10.5958/0974-360X.2016.00440  
5.    Dindayal Darunde, Swati Katiyar. Floating In-situ Gelling System: A review. World Journal Pharmaceutical Research. 2020; 9(7): 929-51. doi:10.20959/wjpr20207-17879
6.    Porwal A, Dwivedi H, Pathak K. Decades of Research in Drug Targeting Using Gastro-Retentive Drug Delivery Systems for Antihypertensive Therapy. Brazilian Journal of Pharmaceutical Sciences. 2017; 53: 1-15. doi: 10.1590/s2175-97902017000300173
7.    Alai M S, Shinkar D M, Saudagar R B. An Review on Floating Mucoadhesive Drug Delivery System. Research Journal of Pharmacy and Technology. 2017; 10(10): 3567-72. doi: 10.5958/0974-360X.2017.00646.1
8.    Ramesh Pareek, Pawan Kumar Sharma, Vandana Sharma. Contemporary Development in Floating Oral In-Situ Gel: A Review. Pharmaceutical and Biosciences Journal. 2019; 7(3): 01-07. doi: 10.20510/ukjpb/7/i3/185552
9.    Bibhuti Sonowal, Pulak Deb, Suvakanta Dash. Studies on In-Situ Forming Thermo Sensitive Injectable Polymeric gel for Sustained Drug Delivery. Research Journal of Pharmacy and Technology. 2017; 10(6): 1840-47. doi: 10.5958/0974-360X.2017.00323.7
10.    Pushpendra. A New Approach to Drug Delivery Using In-Situ Gel for Stomach-Specific Sustained Absorption. European Journal of Molecular and Clinical Medicine. 2022; 9(7): 4497-516. https://ejmcm.com/article_20543_87a71a432d6ea313f2c5a4153cd4f2a5.pdf
11.    Wannasarit S et al. Raft-Forming Gastro-Retentive Formulations Based on Centella Asiatica Extract-Solid Dispersions for Gastric Ulcer Treatment. European Journal Pharmaceutics Science. 2020; 143: 105-204. doi: 10.1016/j.ejps.2019.105204
12.    Anjan K et al. Sustained Release Products: A Review on Formulation Technologies and Regulatory Aspects. Research Journal of Pharmacy and Technology. 2013; 6(12): 1415-25.
https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2013-6-12-13
13.    Padmasri B, Nagarju R, Prasanth D. A Comprehensive Review On In-Situ Gels. International Journal Applied Pharmaceutics. 2020; 12(6): 24. doi: 10.22159/ijap.2020v12i6.38918
14.    Sudhi U S et al. Floating Oral In-Situ Gelling System: A review. Journal of Pharmaceutical Science and Research. 2020; 12(10): 1315-19. https://www.jpsr.pharmainfo.in/Documents/Volumes/vol12issue10/jpsr12102012.pdf
15.    Mounika K et al. In-Situ Gel Polymers: A Review. International Journal of Applied Pharmaceutics. 2021; 13(1): 86-90.doi: 10.22159/ijap.2021v13i1.39504
16.    Sudipta G. A Review on Floating Oral In-Situ Gelling System. International Research Journal of Modernization in Engineering Technology and Science. 2021; 3(6): 1816-23. https://www.irjmets.com/uploadedfiles/paper/volume3/issue_6_june_2021/13287/1628083520.pdf
17.    Kharvi A et al. A Review on Gastro Retentive Drug Delivery Systems with the Special Focus on Floating Drug Delivery. American Journal of PharmTech and Research. 2019; 1: 243-55. http://ajptr.com/assets/upload/publish_article/AJPTR-91003_2033.pdf
18.    Mohanty D et al. A Review on In-Situ Gel: A Novel Drug Delivery System. International Journal of Pharmaceutical Science Review and Reseatch. 2018; 50: 175-81. https://globalresearchonline.net/journalcontents/v50-1/25.pdf
19.    Rabiah Bashir et al. Floating Oral In-Situ Gel: A Review. Journal Drug Delivery Therapeutics. 2019; 9(2): 442-8.doi: 10.22270/jddtv9i2.2372
20.    Ninan S et al. A Review on Floating Drug Delivery System. World Journal of Pharmaceutical and Medical Research. 2018; 4: 275-81. http://www.wjpmr.com/download/article/34042018/1525345584.pdf
21.    Pathan V T et al. In-Situ Gel System-A Novel Approach for Controlled Release. Journal of Global Trends in Pharmaceuticals Sciences. 2020; 11(4): 8564-74. https://www.jgtps.com/admin/uploads/5DzY1y.pdf
22.    Choudhary N G et al. Oral Sustained Release in Situ Gel Forming Polymeric Drug Delivery Systems. Research Journal of Pharmacy and Technology. 2010; 3(3): 682-7.
https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2010-3-3-73
23.    Tushar P, Nikhil S, Yogesh G. A Review on Concept of In-situ gel and it’s Application. International Journal of Pharmacy and Pharmaceutical Research. 2020; 19(4): 594-616. https://ijppr.humanjournals.com/a-review-on-concept-of-in-situ-gel-and-its-applications
24.    Sowjanya M et al. Polymers used in the Designing of Controlled Drug Delivery System. Research Journal of Pharmacy and Technology. 2017; 10(3): 903-12.doi: 10.5958/0974-360X.2017.00168.8
25.    Sonia N et al. A Review on Floating Drug Delivery System. World Journal of Pharmaceutical and Medical Research. 2018; 4(5): 275-81. http://www.wjpmr.com/download/article/34042018/1525345584.pdf
26.    Ganesan V, Jayachandran DL. Design and Evaluation of Matrix Tablets of Ambroxol Hydrochloride using Guar gum. Research Journal of Pharmact and Technology. 2008; 1(4): 507-12
https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2008-1-4-102
27.    Gadge G G. An Overview: Natural Polymers and their Applications. Research Journal of Pharmacy and Technology. 2020; 12(2): 131-6. doi: 10.5958/0975-4377.2020.00023.3
28.    Remya P N et al. Development and Evaluation of Floating in-Situ Gel Solution of Lansoprazole. Research Journal of Pharmacy and Technology. 2017; 10(12): 4323-7. doi: 10.5958/0974-360X.2017.00792.2
29.    Shaikh Siraj N, Jain Vrushabha G, Khan G J. Design, Development and Evaluation of Gastric Floating In-Situ Gel of Piroxicam. International Journal Pharmaceutical Sciences Research. 2020; 11(7): 3409-16. doi: 10.13040/IJPSR.0975-8232
30.    Dalapathi G et al. Design and Evaluation of Glipizide Loaded In-Situ Gel Formulation Using Natural Mucilages for Improved Bioavailability. International Journal of Pharmaceutical Science and Research. 2021; 12 (2): 41-9. doi: 10.21817/ijpsr/2021/v12i2/211202006
31.    Arvapalli Set al. A Novel In-Situ Gel Approach for Sustained Release of Eplerenone. The Pharma Innovation Journal. 2020; 9(3): 527-34. doi: 10.22271/tpi.2020.v9.i3j.4524
32.    Singh Garima S et al. Formulation, Development and Evaluation of Intragastric Floating In-Situ Gel of Brivaracetam. Indo American Journal of Pharmaceutical Science. 2021; 8 (4): 182-198. doi: 10.5281/zenodo.4710589
33.    Parthy et al. Formulation Development and Characterization of Eplerenone In-Situ Oral Gels. International Journal of Indigenous Herbs Drugs. 2021; 6(3): 69-78. doi: 10.46956/ijihd.vi.162
34.    Bapurao PS, Deshmukh V N. Floating Oral In-Situ Gel: A Review. Journal of Emerging Technology and Innovative Research. 2022; 9(2): 274-87. http://www.jetir.org/papers/JETIR2202254.pdf
35.    Antonino et al. Thermoreversible Mucoadhesive Polymer-drug Dispersion For Sustained Local Delivery of Budesonide to Treat Inflammatory Disorders of the GI Tract. Journal of Control Release. 2019; 303: 12–23. doi: 10.1016/j.jconrel.2019.04.011
36.    Daia WG, Dong LC, Song Y. Enhanced Bioavailability of Poorly Absorbed Hydrophilic Compounds Through Drug Complex In-Situ Gelling Formulation. International Journal of Pharmaceutics. 2013; 457: 63–70. doi: 10.1016/j.ijpharm.2013.07.066
37.    Maghraby G M, Elzayat E M, Alanazi F K. Investigation of In-Situ Gelling Alginate Formulations as a Sustained Release Vehicle for Co-precipitates of Dextromethrophan and Eudragit S 100. Acta Pharmaceutica. 2014; 64: 29–44. doi: 10.2478/acph-2014-0002
38.    Tenci M et al. An In Situ Gelling System for the Local Treatment of Inflammatory Bowel Disease (IBD): The Loading of Maqui (Aristotelia chilensis) Berry Extract as an Antioxidant and Anti-Inflammatory Agent. Pharmaceutics. 2019; 11: 611.doi: 10.3390/pharmaceutics11110611

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