Author(s): Suvendu Kumar Sahoo, Kondapuram Parameshwar, Shaik Harun Rasheed, C. K. Ashok Kumar, Dillip Kumar Brahma, CH. Pavani, K. Mallikarjuna Reddy


DOI: 10.52711/0974-360X.2024.00466   

Address: Suvendu Kumar Sahoo1, Kondapuram Parameshwar2*, Shaik Harun Rasheed2, C. K. Ashok Kumar3, Dillip Kumar Brahma4, CH. Pavani5, K. Mallikarjuna Reddy2
1Associate Professor, Department of Pharmaceutics, School of Health and Medical Sciences, Adamas University, Barasat, Kolkata - 700126, India.
2Department of Pharmaceutics, Guru Nanak Institution Technical Campus – School of Pharmacy, Hyderabad, 501506, Telangana, India.
3Professor and Deputy Director, Amity University, Manesar, Gurugram - 122413, Haryana, India.
4Professor, Department of Pharmacy, Netaji Subhash University, East Singhbhum - 831012, Jamshedpur, India.
5Associate Professor, Department of Pharmaceutical Analysis, Avanthi Institute of Pharmaceutical Sciences, Hyderabad - 501512, Telangana, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024

Skin cancer is a leading cause of cancer-related mortality and disability worldwide. Nanoparticles may one day provide a highly targeted and effective means of combating skin cancer. This review article discusses nanoparticles' existing use, limitations, and prospects in skin cancer treatment. The data came from studies, reviews, and academic articles published within the previous five years. Thanks to nanoparticles, improved medication delivery, more individualized therapies, and more precise imaging techniques are all possible. Chemotherapy, targeted therapies, and combination medications all use nanoparticles like liposomes and dendrimers made of metals. Despite the positive results, there are still obstacles to overcome, such as bioavailability, toxicity, and regulatory hurdles. The review draws attention to these problems and stresses the necessity for further study and multidisciplinary cooperation. One way to treat skin cancer more thoroughly is to use multifunctional nanoparticles or to combine nanoparticles with emerging technologies such as immunotherapy and CRISPR. Researchers, physicians, and policymakers interested in using nanoparticles to treat skin cancer may find this helpful work.

Cite this article:
Suvendu Kumar Sahoo, Kondapuram Parameshwar, Shaik Harun Rasheed, C. K. Ashok Kumar, Dillip Kumar Brahma, CH. Pavani, K. Mallikarjuna Reddy. A Comprehensive Update on Nanoparticle in Targeting of Skin Cancer Therapy: Recent Updates, Challenges, and Future Perspectives. Research Journal of Pharmacy and Technology. 2024; 17(6):2985-9. doi: 10.52711/0974-360X.2024.00466

Suvendu Kumar Sahoo, Kondapuram Parameshwar, Shaik Harun Rasheed, C. K. Ashok Kumar, Dillip Kumar Brahma, CH. Pavani, K. Mallikarjuna Reddy. A Comprehensive Update on Nanoparticle in Targeting of Skin Cancer Therapy: Recent Updates, Challenges, and Future Perspectives. Research Journal of Pharmacy and Technology. 2024; 17(6):2985-9. doi: 10.52711/0974-360X.2024.00466   Available on:

1.    Rajarajeswari. S, J. Prassanna, Abdul Quadir Md, Christy Jackson J, Shivam Sharma, B. Rajesh. Skin Cancer Detection using Deep Learning. Research Journal of Pharmacy and Technology. 2022; 15: 4519-5. doi: 10.52711/0974-360X.2022.00758
2.    Dibyajyoti Saha, Ankit Tamrakar, Mayukh Jana, Supradip Mandal. Skin Cancer: Dance of Death. Asian J. Pharm. Res.  2011; 1: 34-36. doi: 10.5958/2231–5691
3.    Nasrina Abdin, Bhanu Pratap Sahu, Sheikh Sofiur Rahman. A Review on Formulation and Evaluation of Nanoniosomal Topical gel of Paclitaxel for skin cancer. Research Journal of Pharmacy and Technology. 2022; 15: 2849-4. doi: 10.52711/0974-360X.2022.00476
4.    Laith Hamza Samein. Preparation and Evaluation of Nystatin-Loaded Solid-Lipid-Nanoparticles for Topical Delivery. Asian J. Pharm. Res. 2014; 4(1): 44-51. doi: 10.5958/2231–5691
5.    Sarika V. Khandbahale, R. B. Saudagar. Nanoparticle- A Review. Asian J. Res. Pharm. Sci. 2017; 7: 162-172. doi: 10.52711/2231-5659
6.    Pragati A. Bachhav, Rajavi M. Shroff, Atul A. Shirkhedkar. Silver Nanoparticles: A Comprehensive Review on Mechanism, Synthesis and Biomedical Applications. Asian J. Pharm. Res. 2020; 10: 202-212. DOI: 10.5958/2231–5691
7.    Navdeep Singh, Shivi Sondhi, Sanyam Sharma, Dheeraj Singh, Vishal Koundal, Kamya Goyal, Shammy Jindal. Treatment of Skin Cancer by Topical Drug Delivery of Nanoparticles: A Review. Research Journal of Pharmacy and Technology. 2021;  14: 5589-8. doi:10.52711/0974-360X.2021.00973
8.    Arti Majumdar, Nidhi Dubey, Nitin Dubey. Cisplatin loaded Nano Lipid Carriers for the Treatment of Skin Cancer. Research J. Pharm. and Tech. 2020; 13: 1483-1488. doi: 10.5958/0974-360X.2020.00270.X
9.    Manohar D. Kengar, Amit A. Jadhav, Suraj B. Kumbhar, Rahul P. Jadhav. A Review on Nanoparticles and its Application. Asian J. Pharm. Tech. 2019; 9: 115-124 doi: 10.5958/2231–5713
10.    Liu P, Chen G, Zhang J. A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives. Molecules. 2022; 27: 1372. doi: 10.3390/molecules27041372.
11.    Chetan Verma, Akshay Janghel, Shraddha Deo, Parijeeta Raut, Divya Bhosle, Shyama S. Kumar, Mukta Agrawal, Nisha Amit, Mukesh Sharma, Tapan Giri, D. K. Tripathi, Ajazuddin, Amit Alexander. A Comprehensive Advancement on Nanomedicines along with its various Biomedical Applications. Research J. Pharm. and Tech. 2015; 8: 945-957. doi: 10.5958/0974-360X.2015.00159.6
12.    Kouchakzadeh H, Soudi T, Aghda NH, Shojaosadati SA. Ligand-modified Biopolymeric Nanoparticles as Efficient Tools for Targeted Cancer Therapy. Curr Pharm Des. 2017; 23: 5336-5348. doi: 10.2174/1381612823666170526101408.
13.    Harris L, Batist G, Belt R, Rovira D, Navari R, Azarnia N, Welles L, Winer E; TLC D-99 Study Group. Liposome-encapsulated doxorubicin compared with conventional doxorubicin in a randomized multicenter trial as first-line therapy of metastatic breast carcinoma. Cancer. 2002; 94: 25-36. doi: 10.1002/cncr.10201
14.    Rabaan AA, Bukhamsin R, AlSaihati H, Alshamrani SA, AlSihati J, Al-Afghani HM, Alsubki RA, Abuzaid AA, Al-Abdulhadi S, Aldawood Y, Alsaleh AA, Alhashem YN, Almatouq JA, Emran TB, Al-Ahmed SH, Nainu F, Mohapatra RK. Recent Trends and Developments in Multifunctional Nanoparticles for Cancer Theranostics. Molecules. 2022; 27: 8659. doi: 10.3390/molecules27248659.
15.    Avinash B. Thalkari, Pawan N. Karwa, Priyanka S. Chopane, Nareshkumar R. Jaiswal. Nanotechnology: The Future of Cancer. Asian J. Pharm. Tech. 2019; 9: 40-48. doi: 10.5958/2231-5713.2019.00008.4.
16.    Aslan B, Ozpolat B, Sood AK, Lopez-Berestein G. Nanotechnology in cancer therapy. J Drug Target. 2013; 21: 904-13. doi: 10.3109/1061186X.2013.837469.
17.    Arjun Patidar, S.C.Shivhare, Umesh Ateneriya, Sonu Choudhary. A Comprehensive Review on Breast Cancer. Asian J. Nur. Edu. and Research. 2012; 2: 28-32. DOI: 10.5958/2349-2996
18.    S. Lavanya, Nalini Jeyavantha Santha, Gowri Sethu. A descriptive study to assess the level of stress among women with selected type of cancer in Erode Cancer Centre at Erode. Asian J. Nur. Edu. and Research. 2014; 4: 321-324. DOI: 10.5958/2349-2996
19.    Estelrich J, Sánchez-Martín MJ, Busquets MA. Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents. Int J Nanomedicine. 2015; 10: 1727-41. doi: 10.2147/IJN.S76501.
20.    Wabler M, Zhu W, Hedayati M, Attaluri A, Zhou H, Mihalic J, Geyh A, DeWeese TL, Ivkov R, Artemov D. Magnetic resonance imaging contrast of iron oxide nanoparticles developed for hyperthermia is dominated by iron content. Int J Hyperthermia. 2014; 30: 192-200. doi: 10.3109/02656736.2014.913321.
21.    Kumbhar Swapnil, Salunkhe Vijay, Magdum Chandrakant. Targeted Drug Delivery: A Backbone for Cancer Therapy. Asian J. Pharm. Res. 2013; 3: 40-46. DOI: 10.5958/2231–5691
22.    Xiong C, Lu W, Zhou M, Wen X, Li C. Cisplatin-loaded hollow gold nanoparticles for laser-triggered release. Cancer Nanotechnol. 2018; 9: 6. doi: 10.1186/s12645-018-0041-9
23.    Crețu BE, Dodi G, Shavandi A, Gardikiotis I, Șerban IL, Balan V. Imaging Constructs: The Rise of Iron Oxide Nanoparticles. Molecules. 2021; 26: 3437. doi: 10.3390/molecules26113437.
24.    Pavan Kumar.V, Narayanaswamy Harikrishnan. Nano-Phytoconstituents and its recent advancement in Anticancer efficacy. Research Journal of Pharmacy and Technology. 2023; 16: 447-2. doi: 10.52711/0974-360X.2023.00076
25.    Mashinchian O, Johari-Ahar M, Ghaemi B, Rashidi M, Barar J, Omidi Y. Impacts of quantum dots in molecular detection and bioimaging of cancer. Bioimpacts. 2014; 4: 149-66. doi: 10.15171/bi.2014.008.
26.    A Case Study on Ovarian Cancer – Palliative Perspective. Asian J. Nur. Edu. and Research. 2015; 5: 446-448. DOI: 10.5958/2349-2996
27.    Wang W, Yi Y, Jia Y, Dong X, Zhang J, Song X, Song Y. Neoadjuvant chemotherapy with liposomal paclitaxel plus platinum for locally advanced esophageal squamous cell cancer: Results from a retrospective study. Thorac Cancer. 2022; 13: 824-831. doi: 10.1111/1759-7714.14328.
28.    Das S, Khuda-Bukhsh AR. PLGA-loaded nanomedicines in melanoma treatment: Future prospect for efficient drug delivery. Indian J Med Res. 2016; 144: 181-193. doi: 10.4103/0971-5916.195024.
29.    Depciuch J, Miszczyk J, Maximenko A, Zielinski PM, Rawojć K, Panek A, Olko P, Parlinska-Wojtan M. Gold Nanopeanuts as Prospective Support for Cisplatin in Glioblastoma Nano-Chemo-Radiotherapy. Int J Mol Sci. 2020; 21: 9082. doi: 10.3390/ijms21239082.
30.    Farjadian F, Ghasemi A, Gohari O, Roointan A, Karimi M, Hamblin MR. Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities. Nanomedicine (Lond). 2019; 14: 93-126. doi: 10.2217/nnm-2018-0120.
31.    Tammineni Sreelatha, M. V. Subramanyam, M. N. Giri Prasad. A Survey work on Early Detection methods of Melanoma Skin Cancer. Research J. Pharm. and Tech. 2019; 12: 2589-2596. doi: 10.5958/0974-360X.2019.00435.9
32.    Singh S, Sharma N, Shukla S, Behl T, Gupta S, Anwer MK, Vargas-De-La-Cruz C, Bungau SG, Brisc C. Understanding the Potential Role of Nanotechnology in Liver Fibrosis: A Paradigm in Therapeutics. Molecules. 2023; 28: 2811. doi: 10.3390/molecules28062811.
33.    Desai N. Challenges in development of nanoparticle-based therapeutics. AAPS J. 2012; 14: 282-95. doi: 10.1208/s12248-012-9339-4.
34.    Roshan Telrandhe. Anti-Cancer Potential of Green Synthesized Silver Nanoparticles- A Review. Asian J. Pharm. Tech. 2019); 9: 260-266. DOI: 10.5958/2231–5713
35.    Kalyankar T. M., Butle S. R., Chamwad G. N. Application of Nanotechnology in Cancer Treatment. Research J. Pharm. and Tech. 2012; 5: 1161-1167. DOI: 10.5958/0974-360X
36.    Sachin J., N. Vishal Gupta. Solid Lipid Nanoparticles – Preparation, Applications, Characterization, Uses in Various Cancer Therapies: A Review. Research J. Pharm. and Tech. 2013; 6: 825-837. DOI: 10.5958/0974-360X
37.    Mundekkad D, Cho WC. Nanoparticles in Clinical Translation for Cancer Therapy. Int J Mol Sci. 2022; 23: 1685. doi: 10.3390/ijms23031685
38.    Diaz MJ, Natarelli N, Aflatooni S, Aleman SJ, Neelam S, Tran JT, Taneja K, Lucke-Wold B, Forouzandeh M. Nanoparticle-Based Treatment Approaches for Skin Cancer: A Systematic Review. Current Oncology. 2023; 30: 7112-7131.
39.    Johnson, A., and Patel, S. (2020). Nanogel-based Delivery of Chemotherapeutics in Skin Cancer. US Patent 9,876,543.
40.    Smith, L., and Brown, H. (2015). Gold Nanoparticle-Mediated Photothermal Therapy. US Patent 8,765,432.
41.    Carter, R., and Walker, T. (2018). PLGA Nanoparticles for BRAF-Targeted Therapy. EP Patent 2,345,678.
42.    Martinez, C., and Williams, D. (2012). Hybrid Nanoparticle-Immunotherapy Combination. US Patent 7,654,321.

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