Author(s): Kozhakhmet Kuneshov, Shora Seidinov, Nurpeis Tulezhanov, Fazladin Tеmurov, Shkurulla Massadikov


DOI: 10.52711/0974-360X.2024.00447   

Address: Kozhakhmet Kuneshov1, Shora Seidinov2*, Nurpeis Tulezhanov3, Fazladin Tеmurov4, Shkurulla Massadikov4
1Khoja Akhmet Yassawi International Kazakh-Turkish University 161200, 29 Bekzat Sattarhanov Ave., Turkistan, Republic of Kazakhstan.
2Department of Surgical Diseases, Khoja Akhmet Yassawi International Kazakh-Turkish University 161200, 29 Bekzat Sattarhanov Ave., Turkistan, Republic of Kazakhstan.
3Department of General Surgery, Khoja Akhmet Yassawi International Kazakh-Turkish University 161200, 29 Bekzat Sattarhanov Ave., Turkistan, Republic of Kazakhstan.
4Department of Surgical Dentistry for Children, Khoja Akhmet Yassawi International Kazakh-Turkish University,161200, 29 Bekzat Sattarhanov Ave., Turkistan, Republic of Kazakhstan.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024

ABSTRACT: Background: The relevance of the stated research subject is determined by the need to conduct an experimental study of the effects of various dosages of sclerosing drugs, such as aethoxysklerol, kanamycin, 70% ethyl alcohol on the general condition of the tissues of the Tunica albuginea. The main purpose of this research is to analyse the degree of influence exerted by sclerosing drugs on the Tunica albuginea when conducting studies using rabbits, as the only laboratory rodents with which it is possible to obtain recombinant pharmaceutical proteins, conduct oral studies, or inject dosage forms into the stomach without violating the integrity of the tablets. Materials and Methods: The leading approach in this research is a practical study performed on 19 rabbits aged 7-8 months, with their division according to the principle of analogues into several main groups (three rabbits in each of them and one rabbit separately) with the introduction of the experimental data obtained in special tables. Results: The results obtained in this research indicate that there are considerable prospects for studying the effect of sclerosing drugs on the Tunica albuginea, from the standpoint of the practical application of the data obtained during the experiment for the treatment of a number of serious diseases in stationary conditions. Conclusion: The study results and the conclusions formulated on their basis have a practical value from the standpoint of obtaining the necessary evidence of the safety of advanced sclerotherapy, which is: improvement of hemodynamic parameters of the testicular parenchyma, the complete absence of structural changes in its tissues and the epididymis in conditions of preserving the full course of spermatogenesis.

Cite this article:
Kozhakhmet Kuneshov, Shora Seidinov, Nurpeis Tulezhanov, Fazladin Tеmurov, Shkurulla Massadikov. The effect of Sclerosing drugs on the Tunica albuginea (Experimental study). Research Journal of Pharmacy and Technology. 2024; 17(6):2846-4. doi: 10.52711/0974-360X.2024.00447

Kozhakhmet Kuneshov, Shora Seidinov, Nurpeis Tulezhanov, Fazladin Tеmurov, Shkurulla Massadikov. The effect of Sclerosing drugs on the Tunica albuginea (Experimental study). Research Journal of Pharmacy and Technology. 2024; 17(6):2846-4. doi: 10.52711/0974-360X.2024.00447   Available on:

1.    Goldman M. Weiss R. Sclerotherapy. Elsevier, Oxford. 2016.
2.    Lakshmi SS. Rao YS. Asha D. Kumari PK. Mallikarjun P. Formulation and evaluation of rosuvastatin-calcium drug transdermal patch. Res J Pharm Technol. 2020; 13(10): 4784.
3.    Alavian S. Nabavi S. Silva AS. Influence of nutrients, bioactive compounds, and plant extracts in liver diseases. Academic Press, London. 2020.
4.    Mazurkevich A. Stadnyk N. Microscopic changes in experimentally damaged rabbit muscles under the influence of transplanted mesenchymal stem cells. Ukrainian Journal of Veterinary Sciences. 2023; 14(2): 96-111.
5.    Dasgupta A. Wahed A. Clinical Chemistry, Immunology and Laboratory Quality Control. Elsevier, Oxford. 2021.
6.    Maslak K. Favara-Scacco C. Barchitta M. Agodi A. Astuto M. Scalisi R. Italia S. BelliaF. Bertuna G. D'Amico S. La Spina M. Licciardello M. Lo Nigro L. Samperi P. Miraglia V. Cannata E. Meli M. Puglisi F. Parisi GF. Russo G. Di Cataldo A. General anesthesia, conscious sedation, or nothing: Decision-making by children during painful procedures. Pediatr Blood Cancer. 2019; 66(5): e27600.
7.    Pinto AMFR. Oliveira OS. Falcao DSC. Direct alcohol fuel cells for portable applications. Academic Press, London. 2018.
8.    De Azambuja Borges CRL. Silva NO. Rodriguez MR. Marinho MAG. de Oliveira FS. Mendes C. Horn AP et al. Dimiristoylphosphatidylcholine/genistein molecular interactions: A physico-chemical approach to anti-glioma drug delivery systems. Chem Phys Lipids. 2019; 225: 104828.
9.    Kurmanova A. Urazbayeva G. Terlikbayeva A. Salimbaeva D. Ayazbekov A. Diagnostic significance of blood lymphocyte activation markers in pre-eclampsia. Clin Exp Immunol. 2024; 215(1): 94-103.
10.    Kshirasagar N.Puchchakayala G. Balamurugan K. Comparative Pharmacokinetic Studies of Marketed and Microsponges Gel Loaded with Diclofenac Diethylamine in Rabbits. Res J Pharm Technol, 2021; 14(12): 6385-6391.
11.    Dobrovanov O. Králinský K. Kovalchuk VP. Ethiological agents of urinal infections and microbial resistance: Retrospective study. LekObz. 2019; (7): 186-190.
12.    Dasgupta A. Alcohol, drugs, genes and the clinical laboratory. Academic Press, London. 2016.
13.    McKeen LW. Permeability properties of plastics and elastomers. William Andrew, Oxford. 2016.
14.    Marakatham S. Shanmugapandiyan P. Bioanalytical Method Development and Validation of Doravirine, Lamavudine and Tenofovir Disoproxil Fumarate using HPLC in Human Plasma. Res J Pharm Technol. 2021; 14(8): 4087-4091.
15.    Dasgupta A. Critical issues in alcohol and drugs of abuse testing. Academic Press, London. 2019.
16.    Komariah C. Salsabila R. Hilda Hapsari A. Rizky Kurnia Putri S.Febianti Z. The Anti-inflammatory effect of Onion extract in rabbit with Corneal ulcer. Res. J. Pharm. Technol. 2021; 14(4): 1854-1858.
17.    Mazumder A. Kumar N. Das S. Kumar SA. Comparative Study on Mono-therapy and Combination Therapy of Additive Drugs (Rebamipide and Pantoprazole) with Amla and Honey combination for the Treatment of Gastroesophageal Reflux Disease and Intestinal motility. Res J Pharm Technol. 2022; 15(9); 4144-4150.
18.    Pokryshko O. Khomenko V. Experimental translocation of intestinal bacteria caused by closed abdominal trauma, acute blood loss, internal haemorrhage. Bull MedBiolog Res. 2023; 16(2): 15-22.
19.    Lisnyy I. Zakalska O. Dmytriiev D. Dmytriiev K. Dobrovanov O. Pre-emptive analgesia with nonsteroidal anti-inflammatory drugs randomized, double-blind placebo-controlled study. LekObz. 2021; 70(5): 195-202.
20.    Sen F. Nanomaterials for direct alcohol fuel cells. Elsevier, Oxford. 2021.
21.    Wahman S. Emara M. Shawky MR. In-Vitro Assessment of Staphylococci Biofilms Formed Under Biologically-Relevant Conditions and Correlation to the Biofilm Genotype. Res J Pharm Technol. 2023; 16(5): 2273-2279.
22.    Kovalchuk VP. NazarchukOA.Burkot VM. Fomina NS.Prokopchuk ZM. Dobrovanov O. Biofilm forming activity of non-fermenting gram-negative bacteria. WiadLek. 2021; 74(2):  252-256.
23.    Singh A. Neurobiology of alcohol and the brain. Academic Press, London. 2020.
24.    Mamontov IN. Results of treatment for Mirizzi syndrome. Klinkhirurhiia. 2016; (9): 25-27.
25.    Vieira WT. de Farias MB. Spaolonzi MP. da Silva MGK.Vieira MGA. Latest Advanced Oxidative Processes Applied for the Removal of Endocrine Disruptors from Aqueous Media – A Critical Report. J Environ Chem Eng, 2021; 9(4): 105748.
26.    Aravind M. Kumar PS. Begum SKA. An Overview of Dendrimers as Novel Carriers in Drug Delivery. Res. J. Pharm. Technol. 2023; 16(4): 2051-2056.
27.    Inticher JJ. Cabrera LC. Guimaraes RE. Zorzo CF. Pellenz L. Seibert D. Borba FH. Advanced Treatment of Water Contaminated with Atrazine, Difenoconazole and Fipronil Mixture, Its By-Products and Bio-Toxicity Levels. J. Environ Chem Eng. 2021; 9(5): 105883.
28.    Zabaiou N. Fouache A. Trousson A. Baron S. Zellagui A. Lahouel M. Lobaccaro J-M. Biological Properties of Propolis Extracts: Something New from an Ancient Product. Chem Phys Lipids. 2017; 207: 214-222.
29.    Beuscher U. Kappert EJ.Wijmans JG. Membrane Research Beyond Materials Science. J Membr Sci. 2021; 9: 56-57.
30.    Kandukoori RN. Yellu RN. Effect of Capsaicin on Pharmacokinetics and Pharmacodynamics of Nateglinide in normal and diabetic rats. Res J Pharm Technol. 2023; 16(3): 991-996.
31.    Shaprynskyi V. Nazarchuk O. Faustova M. Mitiuk B. Dmytriiev D. Dobrovanov O. Kralinsky K. Babina Y. Some aspects of infectious complications in patients with surgical diseases multicentr trials. LekObz. 2020; 69(7-8): 257-260.
32.    Dmytriiev D. Melnychenko M. Dobrovanov O. Nazarchuk O. Vidiscak M. Perioperative hemodynamic protective assessment of adaptive support ventilation usage in pediatric surgical patients. Acute Crit Care.2022; 37(4): 636-643.
33.    Dias IHK. Ferreira R Gruber F. Vitorino R. Rivas-Urbina A. Sanchez-Quesada L. Silva JV et al. Sulfate-Based Lipids: Analysis of Healthy Human Fluids and Cell Extracts. Chem Phys Lipids, 2019; 221: 53-64.
34.    Yadav MK.Saidulu D. Gupta AK. Ghosal PS. Mukherjee A. Status and Management of Arsenic Pollution in Groundwater: A Comprehensive Appraisal of Recent Global Scenario, Human Health Impacts, Sustainable Field-Scale Treatment Technologies. J Environ Chem Eng, 2021: 9(3): 105203.
35.    Mohammed MAQ.Jbori AB. Hepa AAA. The effect of Hyperhomocysteinemia on the Osteoclasts activity in Male New Zealand White Rabbits. Res J Pharm Technol. 2022; 15(2); 5443-5448.
36.    Marwarha G. Raza S. Hammer K.Ghribi O. 27-hydroxycholesterol: A Novel Player in Molecular Carcinogenesis of Breast and Prostate Cancer. Chem Phys Lipids. 2017; 207: 108-126.
37.    Sari DS. Sakinah N. Nuri N. SuswatiE. WidyowatiR.Maduratna E. Chlorogenic Acid Fractionation in Robusta Green Bean Extract as a Combination Agent of Dental Pulp Stem Cells in Periodontal Tissue Engineering. Res J Pharm Technol, 2022; 15(11): 5005-5010.
38.    Jatoi AS. Hashmi Z. Adriyani R. Yuniarto A. Mazari SA. Akhter F. Mubarak NM. Recent Trends and Future Challenges of Pesticide Removal Techniques – A Comprehensive Review. J Environ Chem Eng. 2021; 9(4): 105571.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available