Author(s): Sadia Afrin, Md. Shanzid Hasan, Md. Rezwan Ahmed Mahedi, Ovijet Chandra Kuri, Hrishik Iqbal, Mustafa Jawad Kadham, Mohammad Jamali, Patrik Viktor, Calvin R. Wei, Fredmoore Orosco, Akter Hossain Khan, Nikolaos Syrmos, Fazle Rabbi

Email(s): rezwanmahed747@gmail.com

DOI: 10.52711/0974-360X.2024.00436   

Address: Sadia Afrin1, Md. Shanzid Hasan2, Md. Rezwan Ahmed Mahedi3*, Ovijet Chandra Kuri4, Hrishik Iqbal5, Mustafa Jawad Kadham6, Dr. Mohammad Jamali7, Patrik Viktor8, Calvin R. Wei9, Fredmoore Orosco10, Akter Hossain Khan11, Nikolaos Syrmos12, Fazle Rabbi13
1Department of Pharmacy, Comilla University, Bangladesh.
2Department of Pharmacy, University of Asia Pacific, Bangladesh.
1,3*Research Secretary, Bangladeshi Pharmacists’ Forum (Comilla University), Bangladesh.
4Karadeniz Teknik Universitesi.
5Department of Mathematics and Natural Sciences, Brac University, Bangladesh.
6College of Medical Techniques, Al-Farahidi University, Baghdad, Iraq.
7Faculty of Medical and Health Sciences,Liwa College, Abu Dhabi UAE.
8Óbuda University, Keleti Károly Faculty of Business and Management, Óbuda University, Tavaszmező u. 15-17, H-1084 Budapest, Hungary.
9Department of Research and Development, Shing Huei Group, Taipei, Taiwan.
10Virology and Vaccine Institute of the Philippines Progr

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
Introduction. Worldwide, millions suffer from dengue fever, a mosquito-borne virus that is severe. No particular antiviral drugs exist, making dengue management difficult. New therapies like Eltrombopag Olamine, originally developed for thrombocytopenia, have shown promise. This study examines Eltrombopag Olamine's dengue fever treatment potential using literature, experimental data, and clinical implications. Methodology. This systematic review examines the available literature on the use of Eltrombopag Olamine for the treatment of dengue fever. Thorough keyword searches throughout databases like PubMed and Cochrane, as well as hand-searching of reference lists, provide a large data set for analysis. Result. The small-molecule thrombopoietin receptor agonist eltrombopag olamine showed immunomodulatory properties that are important in the treatment of dengue fever. Studies on dengue patients show that it successfully increases platelet counts, suggesting it may be useful in treating thrombocytopenia. Phase III studies are now investigating its effect on platelet counts and fluid leakage in dengue patients, which might lead to new and improved treatments in the future. Conclusion. The study highlights Eltrombopag Olamine's dengue fever management potential. Its novel approach and favorable patient results, including shortened hospital stays and improved quality of life, provide promise for dengue fever treatment. Policymakers and healthcare providers must fund more research to fully uncover its therapeutic effects. Eltrombopag Olamine might transform dengue treatment, improving efficacy and quality of life for millions.


Cite this article:
Sadia Afrin, Md. Shanzid Hasan, Md. Rezwan Ahmed Mahedi, Ovijet Chandra Kuri, Hrishik Iqbal, Mustafa Jawad Kadham, Mohammad Jamali, Patrik Viktor, Calvin R. Wei, Fredmoore Orosco, Akter Hossain Khan, Nikolaos Syrmos, Fazle Rabbi. Eltrombopag Olamine in Dengue Fever: Systematic Review of Clinical Trials and Beyond. Research Journal of Pharmacy and Technology. 2024; 17(6):2778-2. doi: 10.52711/0974-360X.2024.00436

Cite(Electronic):
Sadia Afrin, Md. Shanzid Hasan, Md. Rezwan Ahmed Mahedi, Ovijet Chandra Kuri, Hrishik Iqbal, Mustafa Jawad Kadham, Mohammad Jamali, Patrik Viktor, Calvin R. Wei, Fredmoore Orosco, Akter Hossain Khan, Nikolaos Syrmos, Fazle Rabbi. Eltrombopag Olamine in Dengue Fever: Systematic Review of Clinical Trials and Beyond. Research Journal of Pharmacy and Technology. 2024; 17(6):2778-2. doi: 10.52711/0974-360X.2024.00436   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-55


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