Author(s): Mukthinuthalapati Mathrusri Annapurna, Pothina Tejasri, Angirekula Narendra

Email(s): mmukthin@gitam.edu

DOI: 10.52711/0974-360X.2024.00431   

Address: Mukthinuthalapati Mathrusri Annapurna*, Pothina Tejasri, Angirekula Narendra
GITAM School of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam, India-530045.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
ABSTRACT: Fenofibrate is a Antihyperlipidemic used to treat cholesterol. New spectrophotometric technique have been developed for the estimation of Fenofibrate in pharmaceutical dosage form. Double beam UV-VIS spectrophotometer (SHIMADZU Model UV-1800) was used for the present study. Fenofibrate has shown linearity over the concentration range 0.5-40 µg/mL for acetate buffer (pH 4.0), phosphate buffer (pH 7.8), 0.1M sodium hydroxide and 1-40 µg/mL for phosphate buffer (pH 5.8), and distilled water respectively and the methods were validated as per ICH guidelines. The proposed methods are simple, economical and can be successfully applied for the assay of Fenofibrate in pharmaceutical dosage forms.


Cite this article:
Mukthinuthalapati Mathrusri Annapurna, Pothina Tejasri, Angirekula Narendra. New Spectrophotometric Method for the Estimation of Fenofibrate. Research Journal of Pharmacy and Technology. 2024; 17(6):2753-6. doi: 10.52711/0974-360X.2024.00431

Cite(Electronic):
Mukthinuthalapati Mathrusri Annapurna, Pothina Tejasri, Angirekula Narendra. New Spectrophotometric Method for the Estimation of Fenofibrate. Research Journal of Pharmacy and Technology. 2024; 17(6):2753-6. doi: 10.52711/0974-360X.2024.00431   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-50


REFERENCES:
1.    M J Chapman Pharmacology of Fenofibrate, Am. J. Med. 83(5B): 2 1-5.
2.    Krishna R. Gupta, Sonali S. Askarkar, Prashant R. Rathod and Sudhir G. Wadodkar. Validated spectrophotometric determination of Fenofibrate in formulation. Der Pharmacia Sinica, 2010; 1(1): 173-178.
3.    Preeti Vinod Gaikwad, Sanjay Dinkar Sawant, Minal Rushikesh Ghante and Neha Manish Munot. Three simple spectrometric methods for Fenofibrate in tablet form. Journal of Pharmacy Research. 2011; 4(6): 1741-1742.
4.    Jadhav Vijay, Raut Chandrakant and Dhabale Pandurang N. UV-Spectrophotometry Estimation of Fenofibrate in Tablet Dosage Form. Asian Journal of Research in Chemistry. 2010; 3(2): 326-328.
5.    Jat R.K, Sharma S, Chippa R.C, Singh Rambir and Alam Imran. Quantitative estimation of Fenofibrate in bulk drug and tablets by UV Visible spectroscopy. Journal of Drug Delivery and Therapeutics; 2012; 2(3): 129-131.
6.    Narendra A, Deepika D and Mathrusri Annapurna M. New spectrophotometric method for the determination of Bosentan – An anti-hypertensive agent in pharmaceutical dosage forms. E- Journal of Chemistry. 2012; 9(2): 700-704.
7.    Mathrusri Annapurna M, Souvik Das, Narendra A and Raja Kumar V. Validated new spectrophotometric methods for the estimation of Bosentan in bulk and pharmaceutical dosage forms. Journal of Pharm Educ Res. 2010; 1 (2): 73-76.
8.    Narendra A, Deepika D and Mathrusri Annapurna M. Validated spectrophotometric methods for the determination of Mycophenolate: an Anti-neoplastic agent in bulk and pharmaceutical dosage forms. Journal of Chemistry. 2013; Article ID 523193.
9.    Mathrusri Annapurna M, Bisht SPS, Ravi Kumar BVV, Raja Kumar V and Narendra A. Spectrophotometric determination of Bosentan and its application in pharmaceutical analysis. International Journal of Comprehensive Pharmacy. 2011; 2 (2): 1-3.
10.    Narendra A, Deepika D and Mathrusri Annapurna M. Determination of Emtricitabine by derivative spectrophotometric method in pharmaceutical dosage forms. Chemical Science Transactions. 2013; 2(3): 978-982.
11.    ICH Q2 [R1] validation of analytical procedures: Text and Methodology: November (2005).



Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available