Author(s): Mohamed Ahmed Samir Abd Elzaher, E. A. El-Kholany, Yasser M. Bakr, Essam S. Khattab, Mohamed B. Ghazy

Email(s): msamir.gimsct@gmail.com

DOI: 10.52711/0974-360X.2024.00430   

Address: Mohamed Ahmed Samir Abd Elzaher1, E. A. El-Kholany2, Yasser M. Bakr3, Essam S. Khattab4, Mohamed B. Ghazy4
1Department of Medical laboratories, Ain Shams Specialized Hospital, Ain Shams University, Cairo, Egypt.
2Department of Special Foods, Food Technology Research Institute, Agricultural Research Center, Giza, Egypt.
3Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
4Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
Pomegranate peel contains a significant quantity of antioxidants, phenols, and flavonoids, which have been shown to have strong anticancer properties. These substances also show potential in treating chronic diseases like stomach ulcers, skin, prostate, colon, and breast cancers. This work aims to evaluate the phytochemical composition of aqueous and ethanolic extracts derived from pomegranate peel and investigate their potential antibacterial and anticancer properties. In comparison with the aqueous extracts, the phenolic and flavonoid components of the pomegranate peel ethanolic extracts showed higher significant levels. Furthermore, ethanolic extracts have demonstrated a stronger antioxidant action. Hesperidin was found to be the main flavonoid compound, while pyrogallol was shown to be the major phenolic compound. When comparing these compounds to the aqueous extract and raw material, the ethanolic extract showed the highest values. Pomegranate peel extract, especially the ethanolic extract, has potent antibacterial and antifungal effects against pathogenic microorganisms. The ethanolic extract demonstrates greater efficacy than the aqueous extract and commercial antibiotics, mainly attributed to its higher polarity and better extraction capacity for active compounds such as phenolic and flavonoid compounds. Pomegranate peel aqueous and ethanolic extract effectively and safely inhibit cell proliferation of liver and colon tumour cells. Pomegranate peel polyphenols cause chemo-prevention and selective toxicity against cancer cells. Both aqueous and ethanolic extracts promote tumour cell apoptosis and necrosis. Notably, the ethanolic extract has more induction of apoptotic and reduction of necrotic cells than the aqueous extract.


Cite this article:
Mohamed Ahmed Samir Abd Elzaher, E. A. El-Kholany, Yasser M. Bakr, Essam S. Khattab, Mohamed B. Ghazy. Evaluation of Biological Activity of Pomegranate Peel Extract as Antioxidant, Antimicrobial and Anticancer. Research Journal of Pharmacy and Technology. 2024; 17(6):2744-2. doi: 10.52711/0974-360X.2024.00430

Cite(Electronic):
Mohamed Ahmed Samir Abd Elzaher, E. A. El-Kholany, Yasser M. Bakr, Essam S. Khattab, Mohamed B. Ghazy. Evaluation of Biological Activity of Pomegranate Peel Extract as Antioxidant, Antimicrobial and Anticancer. Research Journal of Pharmacy and Technology. 2024; 17(6):2744-2. doi: 10.52711/0974-360X.2024.00430   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-49


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