Author(s): Gulzhanat Nurlanova, Aigerim Iskakova, Akezhan Astrakhanov, Aigul Amanzhanova, Galina Zhumagaliyeva

Email(s): nurlanovagulzhanat@gmail.com

DOI: 10.52711/0974-360X.2024.00423   

Address: Gulzhanat Nurlanova*, Aigerim Iskakova, Akezhan Astrakhanov, Aigul Amanzhanova, Galina Zhumagaliyeva
Department of Infectious Diseases and Children's Infections, West Kazakhstan Marat Ospanov Medical University, 030012, 68 Maresyev Str., Aktobe, Republic of Kazakhstan.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
Background: Over the past four years, more than 19000 cases of viral hepatitis B have been registered in Kazakhstan. Mortality from liver cirrhosis as a result of chronic hepatitis B and C ranks first among gastroenterological diseases in the Republic. Toll-like receptor 3 (TLR3) is an effector of innate immune responses and plays a key role in the body's antiviral defense. The purpose of this paper is to analyze the latest scientific data regarding TLR3 polymorphism variants in Turkic-speaking countries and their influence on the predisposition and course of chronic hepatitis B and C. Materials and Methods: To achieve the goal, relevant papers over the past 5 years in scientific medical publications on academic search platforms were selected and processed. Results: The paper analyzes variants of TLR3 polymorphisms in terms of their involvement and predisposition to the development of viral hepatitis among Turkic-speaking peoples. It has been established that the Phe/Leu substitution is associated with a decrease in the activity of adaptive immunity reactions and hyperproduction of interleukins; TLR3 single nucleotide polymorphisms of the rs5743305 (T/A) and rs3775291 species among Turkic-speaking peoples do not affect the nature of progressed viral hepatitis B and C. The rs13126816 variant is associated with a predisposition to infection and the active course of the chronic form of hepatitis C. The G-allele rs13126816 TLR3 is associated with a high probability spontaneous clearance of hepatitis C. The TLR3 single nucleotide polymorphism rs3775291 may be associated with pathological immune responses during the primary development of viral hepatitis B. Conclusion: Thus, the study of the presence of TLR3 polymorphisms in patients of Turkic-speaking countries with viral hepatitis B and C, or in groups of patients with an increased risk of infection, affects the understanding peculiarities of antiviral protection in mutation carriers, the intensity of innate immunity reactions, as well as enables predicting the nature of the course of a chronic process and the risk of developing terminal complications.


Cite this article:
Gulzhanat Nurlanova, Aigerim Iskakova, Akezhan Astrakhanov, Aigul Amanzhanova, Galina Zhumagaliyeva. Polymorphism of the TLR3 gene in Predisposition to Chronic Viral Hepatitis B and C in the population of Turkic-speaking peoples. Research Journal of Pharmacy and Technology. 2024; 17(6):2699-6. doi: 10.52711/0974-360X.2024.00423

Cite(Electronic):
Gulzhanat Nurlanova, Aigerim Iskakova, Akezhan Astrakhanov, Aigul Amanzhanova, Galina Zhumagaliyeva. Polymorphism of the TLR3 gene in Predisposition to Chronic Viral Hepatitis B and C in the population of Turkic-speaking peoples. Research Journal of Pharmacy and Technology. 2024; 17(6):2699-6. doi: 10.52711/0974-360X.2024.00423   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-42


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