Author(s): Preeta Bose, Pintu Kumar De, Dibya Das, Gourav Samajdar

Email(s): pintu.de@jisuniversity.ac.in

DOI: 10.52711/0974-360X.2024.00419   

Address: Preeta Bose, Pintu Kumar De*, Dibya Das, Gourav Samajdar
Department of Pharmaceutical Technology, JIS University, Kolkata, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
The bioavailability of the test preparation was evaluated using a randomised cross-over experiment with two way, two period, and two treatment. The purpose of this study was to compare the bioavailability of the test preparation. The objective of this research was to examine the pharmacokinetic characteristics of paclitaxel liposome and to compare the comparative bioavailability of paclitaxel raw drug in two groups, each of which consisted of six rats. It was decided at random which of the two groups would get the paclitaxel raw drug and which would receive the paclitaxel liposomes. It is possible to draw the conclusion that the test preparation, which is the liposome formulation, is more bioavailable compared to the reference raw drug on the basis of the pharmacokinetic parameters Cmax, tmax, AUCo-t, and AUC0-inf, as well as t1/2 and kel that were investigated. This is possible due to the fact that the parameters which were investigated have all given us positive results.


Cite this article:
Preeta Bose, Pintu Kumar De, Dibya Das, Gourav Samajdar. Comparative Study of Pharmacokinetic Parameters and Bioavailability of Paclitaxel Liposome with Raw Drug. Research Journal of Pharmacy and Technology. 2024; 17(6):2676-0. doi: 10.52711/0974-360X.2024.00419

Cite(Electronic):
Preeta Bose, Pintu Kumar De, Dibya Das, Gourav Samajdar. Comparative Study of Pharmacokinetic Parameters and Bioavailability of Paclitaxel Liposome with Raw Drug. Research Journal of Pharmacy and Technology. 2024; 17(6):2676-0. doi: 10.52711/0974-360X.2024.00419   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-38


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