Author(s): Deeksha S, Sneh Priya, Jainey P James

Email(s): snehpriya123@gmail.com

DOI: 10.52711/0974-360X.2024.00417   

Address: Deeksha S, Sneh Priya*, Jainey P James
Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmaceutics, Mangalore, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
The present aimed to formulate, evaluate and optimise the liposome loaded with Tolnaftate to improve transdermal permeation and compare the drug's permeability with ethosome and transferosome. The liposomes wereprepared using the thin-film hydration method. A 32 factorial design was utilized to assess the influence of two separate factors, namely phospholipids and cholesterol, on various parameters including the percentage entrapment efficiency, vesicle size, zeta potential, and polydispersity index (PDI). Surface morphology was analysed by scanning electron microscopy. The optimised vesicular systems were integrated into a 1% Carbopol 934 gel, and their performance was assessed through in vitro drug release studies and ex vivo permeation studies conducted on goat skin using a modified Franz diffusion cell. The assessment included the determination of the cumulative drug permeation after 480 minutes, as well as the examination of flux and the coefficient of permeability. The vesicle size ranged from 193.4 to 214.0 nm, and the Tolnaftate's encapsulation efficiency ranged from 75.0 to 84.0%. The transfersomes and ethosomes provided the skin with considerably higher levels of cumulative permeation, permeability coefficient, steady-state flux and residual drug than liposomes, conventional gel, or drug suspensions. The formulation of transfersomes can act as a better drug reservoir in the skin and increase the efficacy of tolnaftate, according to the results.


Cite this article:
Deeksha S, Sneh Priya, Jainey P James. Comparative Study of Liposomes, Transfersomes and Ethosomes as Carriers for Enhancing Topical Delivery of Tolnaftate: In vitro Evaluation. Research Journal of Pharmacy and Technology. 2024; 17(6):2661-8. doi: 10.52711/0974-360X.2024.00417

Cite(Electronic):
Deeksha S, Sneh Priya, Jainey P James. Comparative Study of Liposomes, Transfersomes and Ethosomes as Carriers for Enhancing Topical Delivery of Tolnaftate: In vitro Evaluation. Research Journal of Pharmacy and Technology. 2024; 17(6):2661-8. doi: 10.52711/0974-360X.2024.00417   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-36


REFERENCES:
1.    Tong MM, Altman PM, Barnetson RS. Tea Tree Oil In The Treatment Of Tinea Pedis. Australasian Journal of Dermatology. 1992; 33(3): 145–9. doi: 10.1111/j.1440-0960.1992.tb00103.x
2.    Drake LA, Dinehart SM, Farmer ER, Goltz RW, Graham GF, Hordinsky MK, et al. Guidelines of care for superficial mycotic infections of the skin: Tinea corporis, tinea cruris, tinea faciei, tinea manuum, and tinea pedis. Journal of the American Academy of Dermatology. 1996; 34(2): 282–6. doi:10.1016/s0190-9622(96)80135-6
3.    Abousamra MM, Salama AH. Enhancement of the topical tolnaftate delivery for the treatment of tinea pedis via provesicular gel systems. Journal of Liposome Research. 2016; 27(4): 324–34. doi: 10.1080/08982104.2016.1239634
4.    Bseiso E, Nasr M, Gawad NAE, Sammour O. Recent advances in topical formulation carriers of antifungal agents. Indian Journal of Dermatology, Venereology and Leprology. 2015; 81(5): 457. doi: 10.4103/0378-6323.162328
5.    Akbarzadeh A, Sadabady R R , Davaran S, Joo S W, Zarghami N, Hanifehpour Y et al. Liposome: classification, preparation, and Applications. Nanoscale Research Letters. 2013; 8: 1-9. doi: 10.1186/1556-276x-8-102
6.    Patel VB, Misra AN, Marfatia YS. Preparation and Comparative Clinical Evaluation of Liposomal Gel of Benzoyl Peroxide for Acne. Drug Development and Industrial Pharmacy. 2001; 27(8): 863–70. doi: 10.1081/ddc-100107251
7.    Hua S. Comparison of in vitro dialysis release methods of loperamide-encapsulated liposomal gel for topical drug delivery. International Journal of Nanomedicine. 2014; 9: 736-44. doi:10.2147/ijn.s55805
8.    Shabreen MR, Sangeetha S. Ethosomes: A Novel Drug Delivery System And Their Therapeutic Applications -A Review. Research Journal of Pharmacy and Technology. 2020; 13(4): 1970-1978. doi: 10.5958/0974-360X.2020.00355.8
9.    Bragagni M, Mennini N, Maestrelli F, Cirri M, Mura P. Comparative study of liposomes, transfersomes and ethosomes as carriers for improving topical delivery of celecoxib. Drug Delivery. 2012; 19(7): 354–61. doi:10.3109/10717544.2012.724472
10.    Amala Maxwell, Sneh Priya. Nanosized Ethosomes – A Promising Vesicular Drug Carrier for Transdermal Drug Delivery. Research Journal of Pharmacy and Technology. 2019; 12(2): 876-880. doi:10.5958/0974-360x.2019.00150.1
11.    Sneh Priya, Divya Jyothi, Jainey P James, Amala Maxwell. Formulation and Optimisation of Ethosomes loaded with Ropinirole Hydrochloride: Application of quality by Design Approach. Research Journal of Pharmacy and Technology. 2020; 13(9): 4339-4345. doi:10.5958/0974-360x.2020.00767.2
12.    Madhumitha. V, S. Sangeetha. Transfersomes: A Novel Vesicular Drug Delivery System for Enhanced Permeation through Skin. Research Journal of Pharmacy and Technology. 2020; 13(5): 2493-2501. doi: 10.5958/0974-360X.2020.00445.X
13.    Thakur N, Jain P, Jain V. Formulation Development And Evaluation Of Transferosomal Gel. Journal of Drug Delivery and Therapeutics. 2018; 8(5): 168–77. doi:10.22270/jddt.v8i5.1826
14.    Ghanbarzadeh S, Arami S. Enhanced Transdermal Delivery of Diclofenac Sodium via Conventional Liposomes, Ethosomes, and Transfersomes. BioMed Research International. 2013; 2013: 1–7. doi:10.1155/2013/616810
15.    Jainey P. James, Sneh Priya, Divya Jyothi. Effect of PLGA polymer on Antimicrobial Activity and the Release Studies of Nanoparticle Hydrogel Containing Mimosa pudica Extract. Research Journal of Pharmacy and Technology 2018; 11(7): 2876-2880. doi: 10.5958/0974-360X.2018.00530.9
16.    Singh S, Verma D, Mirza MA, Das AK, Dudeja M, Anwer MK, et al. Development and optimisation of ketoconazole loaded nano-transfersomal gel for vaginal delivery using Box-Behnken design: In vitro, ex vivo characterisation and antimicrobial evaluation. Journal of Drug Delivery Science and Technology. 2017; 39: 95–103. doi: 10.1016/j.jddst.2017.03.007
17.    Kumar SR, Mohan V, Srilekha K, Ryaz S, Koteshwara KB, Tippavajhala VK, Kumar L. Diffusion studies of Diclofenac sodium topical gel using Different Synthetic Membranes. Research Journal of Pharmacy and Technology. 2020; 13(7): 3098-3102. doi: 10.5958/0974-360X.2020.00549.1
18.    Agarwal AS, Gautam GG. Formulation, Development and Evaluation of Atorvastatin Ethosomal Gel. International Journal of Pharmaceutical Investigation. 2020; 1041): 452-5. doi:10.5530/ijpi.2020.4.79
19.    Shetty S, Jose J, Kumar L, Charyulu RN. Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasisJournal of Cosmetic Dermatology. 2018; 18(3): 862–9. doi: 10.1111/jocd.12765
20.    Kumar L, Verma R. In vitro evaluation of topical gel prepared using natural polymer. International Journal of Drug Delivery. 2010; 2(1): 58–63. doi:10.5138/ijdd.2010.0975.0215.02012
21.    Ashish D. Mishra, Dignesh M. Khunt, Aakash H Ghayal, C N Patel, Dinesh R. Shah. Formulation and Optimisation of Ethosomes for Transdermal Delivery of Felodipine. Research Journal of Pharmacy and Technology. 2012; 5(12): 1509-17.
22.    Qushawy M, Nasr A, Abd-Alhaseeb M, Swidan S. Design, Optimisation and Characterisation of a Transfersomal Gel Using Miconazole Nitrate for the Treatment of Candida Skin Infections. Pharmaceutics. 2018; 10(1): 1-22. doi:10.3390/pharmaceutics10010026

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