Author(s): Shivlal Yadav, Alpana Ram

Email(s): ramalpana@rediffmail.com

DOI: 10.52711/0974-360X.2024.00408   

Address: Shivlal Yadav*, Alpana Ram
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, (A Central University) Bilaspur, Chhattisgarh.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
In the entire world, hepatocellular carcinoma (HCC) is the second leading cause of cancer death and the fifth prevalent kind of cancer. For hepatocellular carcinoma, herbal microsphere formulations may be more beneficial than conventional formulations due to their improved component solubility, increased bioavailability, and lower dosage, ability to maintain a therapeutic dose over time, improved stability, and protection against chemical and physical degradation. Combining curcumin with linalool formulations might have a synergistic impact.This preliminary research work is proposed for the formulation and characterization of a linalool and curcumin-co-loaded microparticulate system for hepatocellular carcinoma. The characterization of linalool and curcumin as pure drugs was done by UV spectroscopy and FTIR. The microspheres containing curcumin and linalool were characterized in terms of drug release, entrapment efficiency, zeta potential, particle size, and photomicroscopy and FTIR. Model-fitting curves, including the zero-order, first-order, Korsmeyer-Peppas, Higuchi, and Hixson-Crowell models, were used to study the mechanism of drug release. Out of all the formulations, Formulation F2 was accepted. Good drug release and trapping efficiency were found in Formulation F2. Drug release was found to be at its highest when linalool and chitosan concentrations rose, as was the scenario with release also.


Cite this article:
Shivlal Yadav, Alpana Ram. Formulation and In vitro Characterization of Linalool and Curcumin CO-Loaded Microparticulate System for Hepatocellular Carcinoma. Research Journal of Pharmacy and Technology. 2024; 17(6):2613-7. doi: 10.52711/0974-360X.2024.00408

Cite(Electronic):
Shivlal Yadav, Alpana Ram. Formulation and In vitro Characterization of Linalool and Curcumin CO-Loaded Microparticulate System for Hepatocellular Carcinoma. Research Journal of Pharmacy and Technology. 2024; 17(6):2613-7. doi: 10.52711/0974-360X.2024.00408   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-27


REFERENCES:
1.    Gnyana Ranjan Parida, Gurudutta Pattnaik, Amulyaratna Behera. Cellular and Molecular Mechanism of Liver Fibrosis: A Critical Insight. Research Journal of Pharmacy and Technology. 2021; 14(11): 6147-4.
2.    Ivan Rusyn1, Xabier Arzuaga et al.Key characteristics of human hepatotoxicants as a basis for identification and characterization of the causes of liver toxicity. J.Hepatology. 2021; 74 (6): 3486-3496.
3.    Asrani, S.K.; Devarbhavi, H.; Eaton, J.; Kamath, P.S. et al. Burden of liver diseases in the world. J. Hepatol. 2019; 70; 151–171
4.    Dhandhukiya Manavkumar Kanubhai, Saiyed Musaratafrin Sabirali. Hepatocellular Carcinoma: A Review. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(2): 171-9.
5.    Bang A, Dawson LA.etal.  Radiotherapy for HCC: ready for prime time? Jhep Reports. 2019; 1: 131– 137.
6.    Sara Ashtari, Mohamad Amin Pourhoseingholi, AfsanehSharifian, Mohamad Reza Zali. Hepatocellular carcinoma in Asia: Prevention strategy and planning,World J Hepatol. 2015; 7(12): 1708-1717.
7.    Rakesh N Pillai, Beny Baby, AJM Christina, Abin Abraham. Anti-fibrotic effect of ethanolic extract of Cyclea peltata (H.F and T) roots, on carbon tetrachloride induced liver fibrosis. Research J. Pharm. and Tech. 2009; 2(1): 201-205.
8.    Raman Rohilla, Tarun Garg, Amit K. Goyal, and Goutam Rath, Herbal and polymeric approaches for liver-targeting drug delivery: novel strategies and their significance. Informa Healthcare. 2014; Drug Deliv, Early Online: 1–17
9.    Zainab Farooq, Zahraa A. E Al Naqqash, Rasha Eldalawy. Phytochemical Screening, GC/MS Analysis and Antibacterial Activity of Coriandrum sativum L. Seed. Research Journal of Pharmacy and Technology. 2022; 15(9): 4033-6.
10.    Steffi Pulikodan Francis, Muthuirulappan Srinivasan. Enhancing the Bioavailability of a Natural Product Curcumin to increase the Therapeutic Efficacy by a Novel Formulation Technology. Research J. Pharm. and Tech. 2019; 12(6): 2615-2620.
11.    Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Curcumin and its Bioavailability Study. Research J. Pharm. and Tech. 2017; 10(12): 4121-4128.
12.    Gupta S, Parvez N, Bhandari A, Sharma PK. Microspheres based on herbal actives: the less-explored ways of disease treatment. Egypt Pharmaceut J. 2015; (14): 148-57.
13.    Resa P. Parmar, Niranjan S. Kanaki. Development of Simultaneous HPTLC Method for estimation of Boswellic acid, Curcumin and Diosgenin in Polyherbal Transdermal Gel. Res. J. Pharmacognosy and Phytochem. 2018; 10(2): 163-167.
14.    MobeenMohd, Sathish A, Prakash G, Sarika M. Thaiseen B., Ramakrishna R, Formulation And Evaluation Of Mucoadhesive Microspheres Of Pioglitazone Hydrochloride Using A Natural Polymer. IJPSR, 2015; 6(40): 723-737.
15.    Ashwin Kumar Saxena, Aditya Sharma, Navneet Verma. Microspheres as Therapeutically effective Multiparticulate Drug Delivery System: A Systemic Review. Research Journal of Pharmacy and Technology. 2021; 14(6): 3461-0.
16.    Giriraj K T. Herbal Drug Delivery Systems: an Emerging Area in Herbal Drug Research Herbal Drug Delivery Systems:Journal of Chronotherapy and Drug Delivery. 2014; 2(3); 113-119.
17.    Sah S K, Shrivastava B, Verma R, Gupta G. Herbal medicine based novel drug delivery system used for cancer therapy. European Journal of Pharmaceutical and Medical Research 2017; 4(11): 223-232.
18.    Jain A.A., Panigrahy R.N., Mahale A. M. Formulation and Evaluation of Extended Release Metformin Hydrochloride Microspheres by Ionotropic Gelation Technique. Research J. Pharm. and Tech. 2011; 4(7): 1055-1059.
19.    Shashi Kiran Misra., et al. Microspheres: The Efficient Controlled Drug Delivery Carriers. Acta Scientific Pharmaceutical Sciences. 2022; 6(8): 33-44.
20.    Y. Sirisha, Dontharaboina Sneha, Ramya Sri S. Formulation and Evaluation of Sumatriptan Succinate Microspheres by Using Different Polymers. Asian Journal of Pharmacy and Technology. 2023; 13(2): 91-4.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available