Author(s): Vinyas Mayasa, Rebecca, Archana S Patil, Kumaraswamy Gandla, Vinodh Kumar Nelson, Lalitha Repudi.

Email(s): kumaraswamy_pharm@chaitanya.edu.in.

DOI: 10.52711/0974-360X.2024.00404   

Address: Vinyas Mayasa1, Rebecca2, Archana S Patil3, Kumaraswamy Gandla4*, Vinodh Kumar Nelson5, Lalitha Repudi.4
1GITAM School of Pharmacy, GITAM Deemed to be University, Hyderabad, Telangana, India.
2Department of Pharmacology, MNR College of Pharmacy, Sangareddy, Telangana, India.
3Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.
4Department of Pharmacy, Chaitanya Deemed to be University, Gandipet, Himayathnagar, Hyderabad, Telangana.
5Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
Around 21% of the global population suffers from MDD, making it one of the most common mental disorders. People who take antidepressant medications often are more likely to experience undesirable effects such as hypoplasia, cardiovascular toxicity, decreased libido, obesity, and sleep disorders. Studies investigating the potential medicinal benefits of natural remedies for psychiatric diseases have gained increasing attention throughout the past decade. The ethanolic extract of Bacopa monnieri (EEBM) was evaluated for potential anti-depressant effects and anxiolytic activityin animal models. The different phytochemical constituents like Alkaloids, steroids, triterpenoids, tannins and phenolic compounds, saponins were identified. Acute toxicity trials were performed in accordance with OECD standards 425, and the EEBM was shown to be safe at doses up to 2000mg/kg body weight. In vivoanti-depressant activity was conducted utilizing experimental procedures involving animal models, namely testing, TST, and FST.From the study and results, it was observed that the effect of Bacopa was significant and comparable to reference standards.


Cite this article:
Vinyas Mayasa, Rebecca, Archana S Patil, Kumaraswamy Gandla, Vinodh Kumar Nelson, Lalitha Repudi.. Phytochemical Evaluation and Screening of Anti-Depressant and Anxiolytic Activities of Bacopa monniera in rats. Research Journal of Pharmacy and Technology. 2024; 17(6):2587-1. doi: 10.52711/0974-360X.2024.00404

Cite(Electronic):
Vinyas Mayasa, Rebecca, Archana S Patil, Kumaraswamy Gandla, Vinodh Kumar Nelson, Lalitha Repudi.. Phytochemical Evaluation and Screening of Anti-Depressant and Anxiolytic Activities of Bacopa monniera in rats. Research Journal of Pharmacy and Technology. 2024; 17(6):2587-1. doi: 10.52711/0974-360X.2024.00404   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-23


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