Author(s): Nishank Prabhu, Poojary Pooja Srinivas, Gundawar Ravi, Aravind Pai, Girish Pai, Vasudev Pai, Vasanthraju S.G., Muddukrishna Badamane Sathyanarayana

Email(s): krishna.mbs@manipal.edu

DOI: 10.52711/0974-360X.2024.00403   

Address: Nishank Prabhu1, Poojary Pooja Srinivas1, Gundawar Ravi1, Aravind Pai2, Girish Pai3, Vasudev Pai4, Vasanthraju S.G.1, Muddukrishna Badamane Sathyanarayana*1
1Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences (MCOPS)
Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
2Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences (MCOPS) Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
3Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences (MCOPS) Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
4Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences (MCOPS) Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
The present study involves the preparation of co-crystal forms of clotrimazole with co-formers namely nicotinic acid and naringenin. Clotrimazole is a BCS class II drug withlow solubility and high permeability. Hence by preparing the co-crystal, an attempt has been made to improve its solubility. Based on thehydrogen bond formation between the API and co-former, two co-formers were selected: nicotinic acid and naringenin. The co-crystals of clotrimazole with nicotinic acid and naringenin were prepared in the molar ratios of 1:1, 1:2, and 2:1 using dry grinding and solvent evaporation. PXRD, DSC and FTIR confirmed the formation of co-crystals. The solubility of co-crystals of clotrimazole with nicotinic acid was increased 2.07 folds for the ratios 1:2 prepared by solvent evaporation method compared to pure clotrimazole. The saturation solubility was also increased for the co-crystals of clotrimazole with naringenin by 2 folds for the ratio 2:1 prepared by solvent evaporation method compared to pure clotrimazole.


Cite this article:
Nishank Prabhu, Poojary Pooja Srinivas, Gundawar Ravi, Aravind Pai, Girish Pai, Vasudev Pai, Vasanthraju S.G., Muddukrishna Badamane Sathyanarayana. Designing of Stable Co-crystals of Clotrimazole using suitable Coformers. Research Journal of Pharmacy and Technology. 2024; 17(6):2580-6. doi: 10.52711/0974-360X.2024.00403

Cite(Electronic):
Nishank Prabhu, Poojary Pooja Srinivas, Gundawar Ravi, Aravind Pai, Girish Pai, Vasudev Pai, Vasanthraju S.G., Muddukrishna Badamane Sathyanarayana. Designing of Stable Co-crystals of Clotrimazole using suitable Coformers. Research Journal of Pharmacy and Technology. 2024; 17(6):2580-6. doi: 10.52711/0974-360X.2024.00403   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-22


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