Author(s): Aishwarya S. Patil, Mayuri A. Tupe, Devendra S. Shirode

Email(s): dssdypcop@gmail.com

DOI: 10.52711/0974-360X.2024.00401   

Address: Aishwarya S. Patil, Mayuri A. Tupe, Devendra S. Shirode*
Department of Pharmacology, Dr. D.Y. Patil College of Pharmacy, Dr. D.Y. Patil Educational Complex, Sector 29, Pradhikaran Akurdi, Pune, Maharashtra, 411044.
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
Inflammation is body’s defence mechanism. There are various inflammatory and pro-inflammatory factors released in blood after injury. Prevalence of diseases associate with chronic inflammation will increase persistently in next 30 years. 3 in 5 people died with inflammation. Currently various synthetic treatments available but have many side effects. In this view, present study was designed to prepare a promising anti-inflammatory treatment from natural source. Anti-inflammatory effect of polyherbal formulation [prepared from ethanolic extracts of Hugonia mystax and Blumea lacera (1:1)] was evaluated against carrageenan and formalin induced paw oedema. Preliminary phytochemical screening revealed that phenolic acids, flavonoids, tannins, present in formulation. Acute oral toxicity was performed as per OECD guideline, 200 mg/kg and 400mg/kg was selected as lower dose and higher dose respectively. Paw oedema and paw thickness were assessed in all groups. Paw oedema and paw thickness increase in disease control group and significantly decrease in all treatment groups. It is concluded that polyherbal formulation have anti-inflammatory potential due to polyphenols, saponin and terpenoids. Further potent compounds can be isolated for preparation of formulation and clinical trials may be performed.


Cite this article:
Aishwarya S. Patil, Mayuri A. Tupe, Devendra S. Shirode. Anti-inflammatory effect of Polyherbal Formulation. Research Journal of Pharmacy and Technology. 2024; 17(6):2568-2. doi: 10.52711/0974-360X.2024.00401

Cite(Electronic):
Aishwarya S. Patil, Mayuri A. Tupe, Devendra S. Shirode. Anti-inflammatory effect of Polyherbal Formulation. Research Journal of Pharmacy and Technology. 2024; 17(6):2568-2. doi: 10.52711/0974-360X.2024.00401   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-20


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