Author(s): Dmytro Lytkin, Olga Tovchiga, Vladislav Udovitskiy, Olena Barbukho

Email(s): cndl@nuph.edu.ua

DOI: 10.52711/0974-360X.2024.00396   

Address: Dmytro Lytkin1*, Olga Tovchiga2,3, Vladislav Udovitskiy4, Olena Barbukho4
1Educational and Scientific Institute of Applied Pharmacy, National University of Pharmacy, Kharkiv, Ukraine
2Medical University of Gdańsk, Gdańsk, the Republic of Poland
3T.G. Shevchenko National University “Chernihiv Collegium,” Chernihiv, Ukraine
4JSC “Farmak,” Kyiv, Ukraine*
*Corresponding Author

Published In:   Volume - 17,      Issue - 6,     Year - 2024


ABSTRACT:
The aim of the study is to determine the efficacy of the innovative coordinative compound of aluminium and N-(2,3-dimethylphenyl)-anthranilic (mefenamic) acid (CCAA, possessing hepatoprotective and antioxidative activity) on the model of chronic alcohol-induced pancreatitis in rats (Lieber–DeCarli isocaloric alcohol liquid diet for 10 weeks + LPS administration once a week for the three last weeks, 3 mg/kg intravenously). CCA was administered for 21 days at doses of 30, 60, and 120 mg/kg intragastrically. Leucocyte content in the peripheral blood and erythrocyte sedimentation rate, basal glycemia, total lipids level, a-amylase and pancreatic elastase activity in blood serum and the duodenal contents as well as histological structure of the pancreas were evaluated. In the blood serum and the homogenate of the pancreas, glutathione content, superoxide dismutase (SOD), catalase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase activities were measured. The dose-dependent normalizing effect of CCAA was registered by the influence on the non-specific inflammatory markers, pancreatic exocrine function, and cytoarchitectonics of the pancreas (the highest efficacy – at a dose of 120 mg/kg). The normalizing influence on the prooxidant-antioxidant balance markers was not dose-dependent with an especially significant normalizing influence on SOD activity. The results substantiate expanding indications for the of the studied drug.


Cite this article:
Dmytro Lytkin, Olga Tovchiga, Vladislav Udovitskiy, Olena Barbukho. Efficacy of the Coordinative compound of Aluminium and N-(2,3-dimethylphenyl)-anthranilic (mefenamic) acid on the Model of Chronic Alcohol-Induced Pancreatitis. Research Journal of Pharmacy and Technology. 2024; 17(6):2531-0. doi: 10.52711/0974-360X.2024.00396

Cite(Electronic):
Dmytro Lytkin, Olga Tovchiga, Vladislav Udovitskiy, Olena Barbukho. Efficacy of the Coordinative compound of Aluminium and N-(2,3-dimethylphenyl)-anthranilic (mefenamic) acid on the Model of Chronic Alcohol-Induced Pancreatitis. Research Journal of Pharmacy and Technology. 2024; 17(6):2531-0. doi: 10.52711/0974-360X.2024.00396   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-6-15


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