Author(s): Sugasini P, Mahalakshmi V, Muthukumar NJ

Email(s): hasinibose12@gmail.com

DOI: 10.52711/0974-360X.2024.00379   

Address: Sugasini P1*, Mahalakshmi V2, Muthukumar NJ3
1Ph.D Scholar, Department of Sirappu Maruthuvam, National Institute of Siddha, Chennai, Tamil Nadu, India.
2Associate Professor, Department of Siddhar Yoga Maruthuvam, National Institute of Siddha, Chennai, Tamil Nadu, India.
3Professor and HOD, Department of Varma Maruthuvam, National Institute of Siddha, Chennai, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
Herbalplants were used for various diseases for thousands of years by traditional medical practitioners. This work mainly focuses on Siddha herbal plants used in the treatment of diabetes and they have demonstrated anti-diabetic properties, including as increased insulin sensitivity and hypoglycemic effects. One of the most prevalent non-communicable illnesses in the world is diabetes mellitus. A parallel terminology of Madhumegam in Siddha. Siddha literature mentioned the used of plants in the treatment of various ailments. There are few comprehensive investigations on the Siddha medicinal herbs that treat diabetes mellitus. The minimal number of human clinical studies using herbal plants to treat diabetes mellitus that have been reported is shown in this study.In the list of herbal plants are proven antidiabetic and pharmacological effect has compliedInthis review, it is proved that there are many herbs have potent anti-diabetic activity. Searches were conducted across a variety of databases, including Web of Science, Google Scholar, Medline, Scopus, and PubMed, for publications on herbal plants with anti-diabetic properties.


Cite this article:
Sugasini P, Mahalakshmi V, Muthukumar NJ. A Review of A single herbal plant used for Antidiabetic activity in Siddha Materia medica. Research Journal of Pharmacy and Technology. 2024; 17(5):2421-6. doi: 10.52711/0974-360X.2024.00379

Cite(Electronic):
Sugasini P, Mahalakshmi V, Muthukumar NJ. A Review of A single herbal plant used for Antidiabetic activity in Siddha Materia medica. Research Journal of Pharmacy and Technology. 2024; 17(5):2421-6. doi: 10.52711/0974-360X.2024.00379   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-75


REFERENCE:
1    A. Sureka, R. Dhanalakshmi, C. Mary Sharmila, R. Chithra Devi. Comparative Analysis on Significance of Purification Process of Monosilai in Siddha medicine using Modern Instrumental Techniques: Standardization Approach. Asian J. Pharm. Ana. 2019; 9(2): 99-104 https://doi.org/10.5958/2231-5675.2019.00019.X
2    P. Jaya Preethi. Herbal Medicine for Diabetes Mellitus: A Review. Asian J. Pharm. Res. 3(2): 2013; 57-70, DOI: 10.5958/2231–5691
3    S. Cousins. Addressing Asia’s fast growing diabetes epidemic,” Bulletin of the World Health Organization. 2017; 95(8): 550-551,   doi: 10.1155/2021/5570939
4    Li, C.J., Chen, P.N., Li, H.J., Mahmud, T., Wu, D.L., Xu, J., Lan, W.J. Potential Antidiabetic Fumiquinazoline Alkaloids from the Marine-Derived Fungus Scedosporiumapiospermum F41-1. Journal of Natural Products. 2020; DOI: 10.1021/acs.jnatprod.9b01096
5    Cully, T. Diabetes in Numbers. Nature. 2012; 485: S2–S3. https://doi.org/10.1038/485S2a
6    Majeed M, Prakash L. Diabetes management: The therapeutic role of Ayurvedic herbs. J Ethnopharmacol. 2004; 30: 265-79..
7    Ansari P, Flatt PR, Harriott P, Hannan JM, Abdel-Wahab YH. Identification of multiple pancreatic and extra-pancreatic pathways underlying the glucose-lowering actions of Acacia arabica bark in type-2 diabetes and isolation of active phytoconstituents. Plants. 2021 Jun 11; 10(6): 1190. https://doi.org/10.3390/plants10061190
8    K.N. Kuppusamy Mudhaliyar, Siddha maruthuvam (Pothu) (Directorate of Indian Medicine and Homeopathy Publications), 2007,509
9    Rajalakshmi K, Christian GJ, Shanmuga Priya P, Jeeva Gladys R. Validation of Anti-diabetic Potential of Aviraikudineer a Siddha herbal formulation-A Review. IOSR Journal of Dental and Medicinal Sciences. 2015; 14: 7-15. DOI: 10.9790/0853-14750715
10    Gu J, Chen L, Yuan G, Xu X. A drug-target network-based approach to evaluate the efficacy of medicinal plants for type II diabetes mellitus. Evidence-Based Complementary and Alternative Medicine. 2013 Oct; 2013 https://doi.org/10.1155/2013/203614
11    Seino S. Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea. Diabetologia. 2012 Aug; 55(8): 2096-108. https://doi.org/10.1007/s00125-012-2562-9
12    Świderska E, Strycharz J, Wróblewski A, Szemraj J, Drzewoski J, Śliwińska A. Role of PI3K/AKT pathway in insulin-mediated glucose uptake. Blood Glucose Levels. 2018 Nov 5; 1: 1-8.
13    K.S. Murugesamudhaliyar, Siddha materia medica, Medicinal Plant Division ((Directorate ISM&H publications), 2006)
14    Daisy P, Feril G, Kani J. Evaluation of antidiabetic activity of various extracts of Cassia auriculata Linn. bark on streptozotocin-induced diabetic wistar rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4(4): 312-18.
15    Pari L, Latha M. Antidiabetic activity of Cassia auriculata flowers: Effect on lipid peroxidation in streptozotocin diabetes rats. Pharmaceutical Biology. 2002 Jan 1; 40(7): 512-7. https://doi.org/10.1076/phbi.40.7.512.14683
16    Kumar VG, Gokavarapu SD, Rajeswari A, Dhas TS, Karthick V, Kapadia Z, Shrestha T, Barathy IA, Roy A, Sinha S. Facile green synthesis of gold nanoparticles using leaf extract of antidiabetic potent Cassia auriculata. Colloids and Surfaces B: Biointerfaces. 2011 Oct 1; 87(1): 159-63. https://doi.org/10.1016/j.colsurfb.2011.05.016
17    Gupta S, Sharma SB, Singh UR, Bansal SK, Prabhu KM. Elucidation of mechanism of action of Cassia auriculata leaf extract for its antidiabetic activity in streptozotocin-induced diabetic rats. Journal of Medicinal Food. 2010 Jun 1; 13(3): 528-34. https://doi.org/10.1089/jmf.2009.1253
18    Kumudhaveni B, Radha R. Anti-diabetic potential of a traditional Polyherbal Formulation – A Review. Research J. Pharm. and Tech. 2017; 10(6): 1865-1869. doi: 10.5958/0974-360X.2017.00327.4
19    Krishna Ravi, Rosmi Jose, Sumitha SK, Teena Johny, Krishnaveni K, Shanmuga Sundaram R, Sambath Kumar R. An Overview of Treatment Challenges and the role of Herbal Antioxidants in Diabetes Mellitus. Research J. Pharm. and Tech. 2017; 10(8): 2765-2770. doi: 10.5958/0974-360X.2017.00490.5
20    Einstein JW, MohdRais M, Mohd MA. Comparative evaluation of the antidiabetic effects of different parts of Cassia fistula Linn, a Southeast Asian Plant. Journal of Chemistry. 2013 Jan 1; 2013. https://doi.org/10.1155/2013/714063
21    Jangir RN, Jain GC. Evaluation of antidiabetic activity of hydroalcoholic extract of Cassia fistula Linn. pod in streptozotocin-induced diabetic rats. Pharmacognosy J. 2017; 9(5): 599- 60,https://doi.org/10.1076/phbi.40.7.512.14683
22    Shahid Iqbal Mohammed , In vivo antidiabetic and antioxidant activities of Coccinia grandis leaf extract against streptozotocin induced diabetes in experimental rats,Asian Pac J Trop Dis 2016; 6(4): 298-304 https://doi.org/10.1016/S2222-1808(15)61034-9
23    Mohammed SI, Chopda MZ, Patil RH, Vishwakarma KS, Maheshwari VL. in vivo antidiabetic and antioxidant activities of Coccinia grandis leaf extract against streptozotocin induced diabetes in experimental rats. Asian Pacific Journal of Tropical Disease. 2016 Apr 1; 6(4): 298-304. https://doi.org/10.1016/S2222-1808(15)61034-9
24    Silva DN. Eficácia anti-Hipergliceminante, anti perdaóssea e anti-inflamatória do probiótico Lactobacillus rhamnosus EM 1107 emmodelo experimental de periodontiteassociada a diabetes.
25    Shobana S, Harsha MR, Platel K, Srinivasan K, Malleshi NG. Amelioration of hyperglycaemia and its associated complications by finger millet (Eleusine coracana L.) seed coat matter in streptozotocin-induced diabetic rats. British journal of nutrition. 2010 Dec; 104(12): 1787-95 doi:10.1017/S0007114510002977.
26    Divya M, Karthikeyan S, Ravi C, Govindarajan M, Alharbi NS, Kadaikunnan S, Khaled JM, Almanaa TN, Vaseeharan B. Isolation of β-glucan from Eleusine coracana and its antibiofilm, antidiabetic, antioxidant, and biocompatible activities. Microbial Pathogenesis. 2020 Mar 1; 140: 103955. https://doi.org/10.1016/j.micpath.2019.103955
27    Devaki K, Priyanga S, Hemmalakshmi S. Antidiabetic activity of aqueous extract of Erythrina variegata L. bark in streptozotocin induced diabetic rats. Journal of Chemical and Pharmaceutical Research. 2016; 8(4): 306-12
28    Anupama V, Narmadha R, Gopalakrishnan VK, Devaki K. Enzymatic alteration in the vital organs of streptozotocin diabetic rats treated with aqueous extract of Erythrina variegata bark. Int J Pharm Pharm Sci. 2012; 4: 134-47.
29    Kumar A, Lingadurai S, Shrivastava TP, Bhattacharya S, Haldar PK. Hypoglycemic activity of Erythrina variegata leaf in streptozotocin-induced diabetic rats. Pharmaceutical Biology. 2011 Jun 1; 49(6): 577-82. https://doi.org/10.3109/13880209.2010.529615
30    Khanal P, Patil BM. Consolidation of network and experimental pharmacology to divulge the antidiabetic action of Ficus benghalensis L. bark. 3 Biotech. 2021 May; 11(5): 238. https://doi.org/10.1016/j.joim.2020.10.003
31    Veerapur VP, Prabhakar KR, Thippeswamy BS, Bansal P, Srinivasan KK, Unnikrishnan MK. Antidiabetic effect of Ficus racemosa Linn. stem bark in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats: a mechanistic study. Food Chemistry. 2012 May 1; 132(1): 186-93. https://doi.org/10.1016/j.foodchem.2011.10.052
32    Karim S, Khurhsid R, Saeed-ul-Hassan S, Tariq I, Sultana M, Rashid AJ, Shah SH, Murtaza G. Hypoglycemic activity of Ficus racemosa bark in combination with oral hypoglycemic drug in diabetic human. Acta Pol. Pharm.. 2013 Nov 1; 70(6): 1045-9.
33    Pandit R, Phadke A, Jagtap A. Antidiabetic effect of Ficus religiosa extract in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology. 2010 Mar 24; 128(2): 462-6. https://doi.org/10.1016/j.jep.2010.01.025
34    Bhusal A, Jamarkattel N, Shrestha A, Lamsal NK, Shakya S, Rajbhandari S. Evaluation of antioxidative and antidiabetic activity of bark of Holarrhenapubescens wall. Journal of Clinical and Diagnostic Research: JCDR. 2014 Sep; 8(9): HC05. https://doi.org/10.7860%2FJCDR%2F2014%2F7803.4863
35    Karikalan G, Rajangam U. Effect of Marsilea quadrifolia (L.) on carbohydrate metabolic enzymes in alloxan induced diabetic rats. Journal of Pharmaceutical Investigation. 2018 Jul; 48: 477-86 https://doi.org/10.1007/s40005-017-0347-3.
36    Sutar NG, Sutar UN, Behera BC. Antidiabetic activity of the leaves of Mimosa pudica Linn. in albino rats. Journal of herbal Rajagopal K, Sasikala K, Ragavan B. Hypoglycemic and antihyperglycemic activity of Nymphaea stellata flowers in normal and alloxan diabetic rats. Pharmaceutical Biology. 2008 Jan 1; 46(9): 654-9. https://doi.org/10.1080/13880200802182554
37    Rajagopal K, Sasikala K. Antidiabetic activity of hydro-ethanolic extracts of Nymphaea Stellata flowers in normal and alloxan induced diabetic rats. Afr J Pharm Pharmacol. 2008 Oct 1; 2(8): 173-8..
38    Dhanabal SP, Raja MM, Ramanathan M, Suresh B. Hypoglycemic activity of Nymphaea stellata leaves ethanolic extract in alloxan induced diabetic rats. Fitoterapia. 2007 Jun 1; 78(4): 288-91. https://doi.org/10.1016/j.fitote.2007.02.009
39    Ahmed S, Khan RA, Jamil S, Afroz S. Antidiabetic effects of native date fruit Aseel (Phoenix dactylifera L.) in normal and hyperglycemic rats. Pakistan Journal of Pharmaceutical Sciences. 2017 Sep 1; 30(5).
40    Mard SA, Jalalvand K, Jafarinejad M, Balochi H, Naseri MK. Evaluation of the antidiabetic and antilipaemic activities of the hydroalcoholic extract of Phoenix dactylifera palm leaves and its fractions in alloxan-induced diabetic rats. The Malaysian Journal of Medical Sciences: MJMS. 2010 Oct; 17(4):4..
41    Mbagwu HO, Jackson C, Jackson I, Ekpe G, Eyaekop U, Essien G. Evaluation of the hypoglycemic effect of aqueous extract of Phyllanthus amarus in alloxan-induced diabetic albino rats. International Journal of Pharmaceutical and Biomedical Research. 2011; 2: 158-60.
42    Adedapo AA, Ofuegbe SO. The evaluation of the hypoglycemic effect of soft drink leaf extract of Phyllanthus amarus (Euphorbiaceae) in rats. Journal of Basic and Clinical Physiology and Pharmacology. 2014 Feb 1; 25(1): 47-57. https://doi.org/10.1515/jbcpp-2013-0033.
43    Adeneye AA, Amole OO, Adeneye AK. Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice. Fitoterapia. 2006 Dec 1; 77(7-8): 511-4. https://doi.org/10.1016/j.fitote.2006.05.030
44    Biswas A, Chatterjee S, Chowdhury R, Sen S, Sarkar DI, Chatterjee M, Das J. Antidiabetic effect of seeds of Strychnospotatorum Linn. in a streptozotocin-induced model of diabetes. Acta Pol Pharm. 2012 Sep 1; 69(5): 939-43.
45    Subramanian SP. Evaluation of Antidiabetic and Antioxidative Efficacy of StrychnosPotatorum (Nirmali) Seeds Extract in High Fat Diet Fed-Low Dose Streptozotocin Induced Experimental Type 2 Diabetes in Rats. Diabesity. 2020 Feb 16; 6(1): 1-8. https://doi.org/10.15562/diabesity.2020.63
46    Kumar A, Ilavarasan R, Jayachandran T, Deecaraman M, Aravindan P, Padmanabhan N, Krishan MR. Anti-diabetic activity of Syzygiumcumini and its isolated compound against streptozotocin-induced diabetic rats. Journal of Medicinal Plants Research. 2008 Sep 1; 2(9): 246-9.
47    Patel MB, Mishra S. Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine. 2011 Sep 15; 18(12): 1045-52. https://doi.org/10.1016/j.phymed.2011.05.006
48    Rajalakshmi M, Eliza J, Priya CE, Nirmala A, Daisy P. Anti-diabetic properties of Tinospora cordifolia stem extracts on streptozotocin-induced diabetic rats. Afr J Pharm Pharmacol. 2009 May 1; 3(5): 171-80.
49    Farook SM, Atlee WC. Antidiabetic and hypolipidemic potential of Tragiainvolucrata Linn. In streptozotocin-nicotinamide induced type II diabetic rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2011; 3(4): 103-9.
50    Rao VN, Benoy K, Hemamalini K, Kumar SS, Satyanarayana S. Anti-diabetic activity of root extracts of Tragiainvolucrata. Pharmacologyonline. 2007; 2: 203-17.
51    Al-Awaida WJ, Sharab AS, Al-Ameer HJ, Ayoub NY. Effect of simulated microgravity on the antidiabetic properties of wheatgrass (Triticum aestivum) in streptozotocin-induced diabetic rats. npj Microgravity. 2020 Feb 24; 6(1): 6. https://doi.org/10.1038/s41526-020-0096-x
52    Ajiboye BO, Oloyede HO, Salawu MO. Antidiabetic Activity of Triticum aestivum Seed–Based Diet on Alloxan-Induced Diabetic Rats. Journal of Dietary Supplements. 2020 Mar 3; 17(2): 133-49., https://doi.org/10.1080/19390211.2018.1492485
53    Dahake AP, Chakma CS, Chakma RC, Bagherwal P. Antihyperglycemic activity of methanolic extract of Madhuca longifolia bark. Diabetologiacroatica. 2010 Mar 1; 39(1): 3-8.
54    Jarald E, Joshi SB, Jain DC. Biochemical study on the hypoglycaemic effects of extract and fraction of Acacia catechu willd in alloxan-induced diabetic rats. Dubai Diabetes and Endocrinology Journal. 2009 Mar 1; 17(2): 63-9. https://doi.org/10.1159/000497675
55    Bhargava A, Velmurugan C. Anti-diabetic activity of Gossypium herbaceum by alloxan induced model in rats. PharmaTutor. 2014 Apr 1; 2(4): 126-32.
56    R. Vadivelan, R. Gopala Krishnan, R. Kannan, Antidiabetic potential of Asparagus racemosusWilld leaf extracts through inhibition of α-amylase and α-glucosidase, Journal of Traditional and Complementary Medicine, 2019; 9(1): 1-4, https://doi.org/10.1016/j.jtcme.2017.10.004
57    Kumar MS, Mythili A in vivo and invitro leaf extract of bambusa vulgaris, root extract of pandanus odoratissimus stimulates β cell regeneration and antidiabetic activity in wister rats.
58    Gayathri M, Kannabiran K. Hypoglycemic activity of Hemidesmus indicus R. Br. on streptozotocin-induced diabetic rats. International Journal of Diabetes in Developing Countries. 2008 Jan; 28(1): 6. https://doi.org/10.4103%2F0973-3930.41979
59    Chauhan NS, Dixit VK. Phcog mag.: Research Article Antihyperglycemic activity of the ethanolic extract of Curculigoorchioides Gaertn. Phcog Mag. 2007 Oct; 3(12): 237.
60    Balasubramanian T, Lal MS, Sarkar M, Chatterjee TK. Antihyperglycemic and antioxidant activities of medicinal plant Stereospermumsuaveolens in streptozotocin-induced diabetic rats. Journal of Dietary Supplements. 2009 Jan 1; 6(3): 227-51. https://doi.org/10.1080/19390210903070780
61    Ansari P, Hannon-Fletcher MP, Flatt PR, Abdel-Wahab YH. Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats. Bioscience Reports. 2021 Jan; 41(1): BSR20203824. https://doi.org/10.1042/BSR20203824
62    Veeramani C, Pushpavalli G, Pugalendi KV. Antihyperglycaemic effect of Cardiospermum halicacabum Linn. leaf extract on STZ-induced diabetic rats. Journal of Applied Biomedicine. 2008 Mar 1; 6(1).
63    Shen CY, Wan L, Wang TX, Jiang JG. Citrus aurantium L. var. amara Engl. inhibited lipid accumulation in 3T3-L1 cells and Caenorhabditis elegans and prevented obesity in high-fat diet-fed mice. Pharmacological Research. 2019 Sep 1; 147: 104347. https://doi.org/10.1016/j.phrs.2019.104347,
64    Hamid K, Ullah MO, Sultana S, Howlader MA, Basak D, Nasrin F, Rahman MM. Evaluation of the Leaves of Ipomoea aquatica for its Hypoglycemic and Antioxidant Activity. Journal of Pharmaceutical Sciences and Research. 2011 Jul 1; 3(7): 1330.
65    Kumawat BK, Chand T, Singh Y. Antidiabetic and antihyperlipidemic effects of alcoholic and aqueous stem bark extracts of Limoniaacidissima, linn in alloxan induced diabetic rats. International Journal of Phytomedicine. 2012 Apr 1; 4(2):187.
66    Prathapan A, Nampoothiri SV, Mini S, Raghu KG. Antioxidant, antiglycation and inhibitory potential of Saracaashoka flowers against the enzymes linked to type 2 diabetes and LDL oxidation. European Review for Medical and Pharmacological Sciences. 2012 Jan 1; 16(1): 57-65.
67    Kumar S, Narwal S, Kumar D, Singh G, Narwal S, Arya R. Evaluation of antihyperglycemic and antioxidant activities of Saracaasoca (Roxb.) De Wild leaves in streptozotocin induced diabetic mice. Asian Pacific Journal of Tropical Disease. 2012 Mar 1; 2(3): 170-6. https://doi.org/10.1016/S2222-1808(12)60041-3
68    Ahmad M, Zaman F, Sharif T, Ch MZ. Antidiabetic and hypolipidemic effects of aqueous methanolic extract of Acacia nilotica pods in alloxan-induced diabetic rabbits. Scandinavian Journal of Laboratory Animal Science. 2008 Dec 1; 35(1): 29-34. https://doi.org/10.23675/sjlas.v35i1.135
69    Sai Saran Thokada, Harsha Kandregula, VinodkumarMugada. Prevalence of Sub-Clinical Hypothyroidism among Diabetes Mellitus Patients with Vascular Complications. Asian J. Res. Pharm. Sci. 2018; 8(4): 253-257. doi: 10.5958/2231-5659.2018.00042.5
70    Preeti Tiwari. Antidiabetic Potential of Balarishta Prepared by Traditional and Modern Methods in Alloxan Induced Diabetic rats. Asian J. Research Chem. 2014; 7(7): 659-663
71    J. Bini Janet, K. Kanchana, T. Nirmala. Effect of Structured Teaching Programme on knowledge regarding Foot Care among Patients with Diabetes Mellitus at selected Hospital, Coimbatore. Int. J. of Advances in Nur. Management. 2019; 7(4): 336-338. doi: 10.5958/2454-2652.2019.00078.
72    Tiwari P. Antidiabetic Potential of Balarishta Prepared by Traditional and Modern Methods in Alloxan Induced Diabetic rats. Asian Journal of Research in Chemistry. 2014; 7(7): 659-63.
73    Bhanushali SM, Modh KM, Anand IS, Patel CN, Dave JB. Novel Approaches for Diabetes Mellitus: A Review. Research Journal of Pharmacology and Pharmacodynamics. 2010; 2(2): 141-7..


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