Author(s): Ranim Alkheder, Mariam Al Zangiligi, Ramadan Mussa, Azizkhon R Askarov, Svetlana N Suslina

Email(s): 1042205181@pfur.ru , mariam.salih@mail.ru , mussa-r@rudn.ru , 1042205181@pfur.ru , mariam.salih@mail.ru , mussa-r@rudn.ru , suslinа-sn@rudn.ru

DOI: 10.52711/0974-360X.2024.00372   

Address: Ranim Alkheder1, Mariam Al Zangiligi1, Ramadan Mussa1, Azizkhon R Askarov2, Svetlana N Suslina1
1RUDN Univeristy.
2Moscow State University of Medicine and Dentistry.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
The Asteraceae family is one of the largest and most numerous families of flowering plants in the world, and to which the genus of Matricaria belongs, which is the object of our study: golden chamomile Matricaria aurea (Loefl.) Sch.Bip. (M. aurea (Loefl.)) and Matricaria chamomilla (L.) (M. chamomilla (L.). These types of Matricaria are widely distributed in Russia and the Middle East and therefore can be successfully used in the treatment of inflammatory diseases. The rich composition of biologically active compounds of chamomile has been well studied in numerous chemical studies. The most active components of M. aurea (Loefl.) are flavonoids, apigenin, luteolin, quercetin, patuletin and, also essential oil components such as a-bisabolol, its oxides and azulenes. M. aurea (Loefl.) contains active substances with anti-inflammatory, antimicrobial, deodorant, carminative, sedative, anticatarrhal and antispasmodic properties. According to many clinical studies, the high potential of M. aurea (Loefl.) for the prevention and treatment of inflammatory diseases of various localization has been convincingly shown. Also, raw M. aurea (Loefl.) can be a source of various compounds used for the treatment of chronic periodontitis. In studies, the antibacterial effect of M. aurea (Loefl.) was obtained in the treatment of inflammatory diseases caused by Bacillus subtilis, Streptococcus pyogenes, S. aureus. It has also been proven effective in inflammatory diseases of the urinary system and intestines, antispasmodic effect. As for M. chamomilla (L.), its most active constituents are farnesene, chamazulene, flavonoids (including apigenin, quercetin, patuletin and luteolin) and coumarin. M. chamomilla (L.) topical preparations are highly effective in the complex treatment of many skin diseases, including ultraviolet-induced erythema, contact dermatitis, phlebitis, atopic eczema, radiodermatitis, and for wound healing. Also, preparations derived from M. chamomilla (L.) are used to treat various diseases, including diabetes, nervous disorders, diarrhea, stomatitis, microbial infections, antiseptic, anti-inflammatory, and gastric disorders. In addition, M. chamomilla (L.) has antioxidant, antibacterial, antifungal, antiparasitic, antipyretic, anti-inflammatory, and analgesic activity.


Cite this article:
Ranim Alkheder, Mariam Al Zangiligi, Ramadan Mussa, Azizkhon R Askarov, Svetlana N Suslina. Evaluation the activity of Matricaria aurea L. and Matricaria chamomilla L. in the treatment of some Inflammatory diseases to justify appropriate Dosage Formulation. Research Journal of Pharmacy and Technology. 2024; 17(5):2379-4. doi: 10.52711/0974-360X.2024.00372

Cite(Electronic):
Ranim Alkheder, Mariam Al Zangiligi, Ramadan Mussa, Azizkhon R Askarov, Svetlana N Suslina. Evaluation the activity of Matricaria aurea L. and Matricaria chamomilla L. in the treatment of some Inflammatory diseases to justify appropriate Dosage Formulation. Research Journal of Pharmacy and Technology. 2024; 17(5):2379-4. doi: 10.52711/0974-360X.2024.00372   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-68


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