Author(s): Doniyor Umarov, Natalya Tseomashko, Aziza Abidova, Nadjiye Abrekova, Nuriya Beknazarova, Shukhrat Turaboev, Sardor Makhmudov, Azimjon Mamadrahimov, Farkhod Eshboev, Bakhodir Sagdullaev

Email(s): doniyor515@mail.ru

DOI: 10.52711/0974-360X.2024.00355   

Address: Doniyor Umarov1*, Natalya Tseomashko2, Aziza Abidova2, Nadjiye Abrekova1, Nuriya Beknazarova1, Shukhrat Turaboev1, Sardor Makhmudov1, Azimjon Mamadrahimov1, Farkhod Eshboev3,4, Bakhodir Sagdullaev1
1A.S. Sodikov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, 83 Mirzo Ulugbek Str., Tashkent 100125, Uzbekistan.
2Tashkent Medical Academy, 2 Farobiy, Tashkent 2100109, Uzbekistan.
3S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 77 Mirzo Ulugbek Str., Tashkent 100170, Uzbekistan.
4School of Chemical Engineering, New Uzbekistan University, Movarounnahr street, Mirzo-Ulug'bek District, 100000, Tashkent, Uzbekistan.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
The wound healing process is of great importance in the field of medicine and healthcare. Effective wound healing is crucial for restoring tissue integrity, preventing infection, and promoting overall patient well-being. In recent years, there has been growing interest in developing innovative approaches to enhance wound healing. This study focuses on the evaluation of wound healing potential of a composition (polyphenolic extract derived from the of Rumex confertus Willd., collagen from animal tendons, and wound covering film). The study demonstrates the superior wound healing activity of this composition compared to a commercial reference drug “NeuSkin-F”. Additionally, the R. confertus Willd. extract showed significant antibacterial activity against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus with inhibition zones ranging from 12.35±0.14 to 27.2±0.2. The intragastric administration of the extract in experimental animals did not result in toxicity effects or mortality. Furthermore, the extract demonstrated a lack of local skin or skin-resorptive effects, implying that it does not cause any adverse reactions or damage to the skin upon application. Additionally, it did not exhibit an irritating effect on the mucous membrane of the eye, suggesting its potential for safe use without causing discomfort or irritation to ocular tissues. These indicate that the extract is non-toxic and can be classified as a practically non-toxic substance, falling under the 5th hazard class. These findings regarding the safety of the R. confertus Willd. extract highlight its potential as a viable candidate for further development and exploration in wound healing applications.


Cite this article:
Doniyor Umarov, Natalya Tseomashko, Aziza Abidova, Nadjiye Abrekova, Nuriya Beknazarova, Shukhrat Turaboev, Sardor Makhmudov, Azimjon Mamadrahimov, Farkhod Eshboev, Bakhodir Sagdullaev. Wound healing and Antimicrobial properties of extract of the Rumex confertus Willd. Research Journal of Pharmacy and Technology. 2024; 17(5):2256-1. doi: 10.52711/0974-360X.2024.00355

Cite(Electronic):
Doniyor Umarov, Natalya Tseomashko, Aziza Abidova, Nadjiye Abrekova, Nuriya Beknazarova, Shukhrat Turaboev, Sardor Makhmudov, Azimjon Mamadrahimov, Farkhod Eshboev, Bakhodir Sagdullaev. Wound healing and Antimicrobial properties of extract of the Rumex confertus Willd. Research Journal of Pharmacy and Technology. 2024; 17(5):2256-1. doi: 10.52711/0974-360X.2024.00355   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-51


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