Author(s): Somasundaram Ramachandran, Ramya Manthena, Chandravadivelu Gopi, Magharla D Dhanaraju

Email(s): ramsnetin@yahoo.com

DOI: 10.52711/0974-360X.2024.00350   

Address: Somasundaram Ramachandran1*, Ramya Manthena1, Chandravadivelu Gopi2, Magharla D Dhanaraju3
1Pharmacology Department, GIET School of Pharmacy, Rajamahendravaram, Andhra Pradesh - 533296, India.
2Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajamahendravaram - 533296, Andhra Pradesh, India.
3Director, Research Lab, GIET School of Pharmacy, Rajamahendravaram, Andhra Pradesh - 533296, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
Anemia is associated with increased morbidity and mortality in women and children. It causes a poor birth outcome, decline in mental ability, weakness and affects the reproductive age of women. The objective of this study is to assess the enhanced absorption of non-heme iron by using foods rich in Vitamin-C. Anemia was induced by intraperitoneal administration of 60mg/kg phenylhydrazine in rats. Later they were fed with heme iron food, non-heme iron food and non-heme iron food along with vitamin-C rich food supplements for 28 days according to the designated groups . Group 1(Negative control), Group 2(Positive control), Group 3(Heme food), Group 4(Non-heme food) and Group 5(Non-heme food along with Vitamin-C food supplements). On the last day, the blood sample was collected from the rats by retro orbital puncture and analysed. The result reveals that there is a steep increase of iron absorption in non-heme iron food along with vitamin-C food supplements group and the level of red blood cell, haemoglobin and red blood cell indices were compared with rats treated with heme food. The vitamin-C food supplements enhanced iron absorption in non-heme iron food by forming a chelate with ferric iron at an acid pH that remains soluble at the alkaline pH of the small intestine. Therefore the study strongly recommended that the usage of vitamin-C rich food supplements along with non-heme food enhances the absorption of iron in vegetable foods.


Cite this article:
Somasundaram Ramachandran, Ramya Manthena, Chandravadivelu Gopi, Magharla D Dhanaraju. Enhancement of Non-Heme Iron Absorption from Vegetable Foods by using Vitamin-C supplements in Wistar Rats. Research Journal of Pharmacy and Technology. 2024; 17(5):2224-8. doi: 10.52711/0974-360X.2024.00350

Cite(Electronic):
Somasundaram Ramachandran, Ramya Manthena, Chandravadivelu Gopi, Magharla D Dhanaraju. Enhancement of Non-Heme Iron Absorption from Vegetable Foods by using Vitamin-C supplements in Wistar Rats. Research Journal of Pharmacy and Technology. 2024; 17(5):2224-8. doi: 10.52711/0974-360X.2024.00350   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-46


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