Author(s): Uma Maheswari Kolipaka, Bodla R. B.

Email(s): rameshbodla@gmail.com

DOI: 10.52711/0974-360X.2024.00346   

Address: Uma Maheswari Kolipaka, Bodla R. B.*
Research Scholar, DIPSAR: Delhi Institute of Pharmaceutical Sciences and Research,
Constituent College of Delhi Pharmaceutical Sciences and Research University (DPSRU),
M.B Road, Pushpa Vihar, Sector - 3, New Delhi -110017.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
In this study, the biotransformation of Tetracycline by two strains of filamentous fungi, namely Aspergillus niger and Candida albicans were investigated. They were screened for their ability to biotransform Tetracycline, and both of them were able to produce 3 metabolites. Their structures were established based on TLC, HPLC, and liquid Chromatography with mass spectrometry data analyses, and 2 of them are new compounds. The two fungal strains exhibited distinct biocatalytic features. A.niger could catalyze hydroxylation and carbonylation reactions, whereas C. albicans preferred to catalyze hydroxylation and acetylation reactions. These highly specific reactions are difficult to achieve by chemical synthesis, particularly under mild conditions. Results from this investigation lead to a better estimation of the destiny and shipping of antibiotics to modified/ transformed which will be having more advantages than that of existing forms.


Cite this article:
Uma Maheswari Kolipaka, Bodla R. B.. Studies on Microbial Biotransformation of Tetracycline by Fungi Aspergillus niger and Candida albicans. Research Journal of Pharmacy and Technology. 2024; 17(5):2201-5. doi: 10.52711/0974-360X.2024.00346

Cite(Electronic):
Uma Maheswari Kolipaka, Bodla R. B.. Studies on Microbial Biotransformation of Tetracycline by Fungi Aspergillus niger and Candida albicans. Research Journal of Pharmacy and Technology. 2024; 17(5):2201-5. doi: 10.52711/0974-360X.2024.00346   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-42


REFERENCES:
1.    Sabreen A. Kamal, Lena Fadhil Hamza, Israa Adnan Ibraheam. Characterization of Antifungal Metabolites Produced by Aeromonas Hydrophila and Analysis of its Chemical Compounds Using GC-MS.Research J. Pharm. and Tech. 2017; 10(11): 3845-3851. doi: 10.5958/0974-360X.2017.00697.7
2.    Tan Wen-Si, Yin Wai-Fong, Chan Kok-Gan. Insights into the Quorum-Sensing Activity in Aeromonas hydrophila Strain M013 as Revealed by Whole-Genome Sequencing. Genome A. 2015; 3 (1): 1–2.
3.    Hazen TC, Flierman CB, Hirsch RP, Esch GW. Prevalence and distribution of Aeromonas hydrophila in the United States. Appl. Environ. Microbiol. 1978; 36: 731–738.
4.    Van der Kooj D. Properties of Aeromonads and their occurence and hygenic significance in drinking water. Zentralb. Bakt. Hyg. B. 1988; 187: 1–17.
5.    Kaper, JB, Lockman, H, Colwell, RR, Joseph, SW. Aeromonas hydrophila: ecology and toxigenicity of isolates form an estuary. J. Appl. Microbiol. 1980; 50:359–377.
6.    Mathewson JJ, Dupont, HL. Aeromonas species: role as human pathogens, In: Remington, JS., Swartz, M.N. (eds.). Current Clinical Topics in Infectious Diseases. Vol 12e. Cambridge: Blackwell Scientific pp. 1992; 26–36.
7.    Albert, M. John. Prevalence of Enterotoxin Genes in Aeromonas spp. Isolated from Children with Diarrhea, Healthy Controls, and the Environment. Journal of Clinical Microbiology. 2000;  38(10); 3785-3790.
8.    Chopra AK, X.-J. Xu, D. Ribardo M, Gonzalez K, Kuhl J W. Peterson CW Houston. The Cytotoxic Enterotoxin of Aeromonas hydrophila Induces Pro-inflammatory Cytokine Production and Activates Arachidonic Acid Metabolism in Macrophages. Infection and Immunity.  2000;  68(5);  2808-2818.
9.    Cipriano, Rocco L. Aeromonas hydrophila and Motile Aereomonad Septicemias of Fish. Fish and Disease Leaflet. 2001; 68.
10.    Seetha KS, Jose BT, Jasthi A. Meningitis due to Aeromonas hydrophila." Indian J Med Microbiol. 2004; 22: 191-192.
11.    Xu, Xin-J, M R. Ferguson, V L, Popov CW, Houston J W, Peterson A K. Chopra. "Role of a Cytotoxic Enterotoxin in Aeromonas-Mediated Infections: Development of Transposon and Isogenic Mutants. Infect Immun. 1998;  66(8): 3501-3509,
12.    Rekha Seshadri, Sam W. Joseph, Ashok K. Chopra, Jian Sha, Jonathan Shaw, Joerg Graf, Daniel Haft, Martin Wu. Genome Sequence of Aeromonas hydrophila ATCC 7966T: Jack of All Trades. J Bacteriol. 2006.
13.    H. B. Yu, P. S. Srinivasa Rao, H. C. Lee, S. Vilches, S. Merino, J. M. Tomas, and K. Y. Leung. A Type III Secretion System Is Required for Aeromonas hydrophila AH-1 Pathogenesis. Infect Immun. 2004; 72: 1248–1256.
14.    Vilches S, Wilhelms M, Yu HB, Leung KY, Tomas JM, Merino S. Aeromonas hydrophila AH-3 AexT is an ADP-ribosylating toxin secreted through the type III secretion system. Microb Pathog. 2007; PMID: 17689917
15.    Sha J, Wang SF, Suarez G, Sierra JC, Fadl AA, Erova TE, Foltz SM, Khajanchi BK, Silver A, Graf J, Schein CH, Chopra AK. “Further characterization of a type III secretion system (T3SS) and of a new effector protein from a clinical isolate of Aeromonas hydrophila-Part I”, Microb Pathog. 2007; 43(4): 127-46, Epub 2007, PMID: 17644303.
16.    Johanna C Sierra, Giovanni Suarez, Jian Sha, Sheri M Foltz, Vsevolod L Popov, Cristi L Galindo, Harold R Garner, Ashok K Chopra “Biological characterization of a new type III secretion system effector from a clinical isolate of Aeromonas hydrophila-Part II”, Microb Pathog. 2007; 43(4): 147-60.
17.    Al-Fatlawy HNK, HA Al-Hadrawy. Isolation and characterization of A. hydrophila from the Al-Jadryia River in Baghdad (Iraq). American Journal of Educational Research. 2014; 2(8): 658-662.
18.    Harris LJ, JN Farber, LR Beuchat, ME Parish, TV Suslow, EH Garrett, F.F. Busta. “Outbreaks associated with fresh produce: incidence, growth, and survival of pathogens in fresh and fresh-cut produce. Comprehensive Reviews in Food Science and Food Safety. 2003; 2: 78-141.
19.    Janda JM, SL Abbott. The genus Aeromonas: taxonomy, pathogenicity, and infection. Clinical Microbiology Reviews. 2010; 23(1): 35-73.
20.    Radu S, N Ahmad, FH Ling, A Reezal. Prevalence and resistance to antibiotics for Aeromonas species from retail fish in Malaysia. International Journal of Food Microbiology. 2003; 81:261-266.
21.    Abbott, S.L., W.K.W. Cheung, and J.M. Janda. The genus Aeromonas: biochemical characteristics, atypical reactions, and phenotypic identification schemes. Journal of Clinical Microbiology. 2003; 41(6): 2348-2357.
22.    Nicolaou, K. C.; Hale, C. R.; Nilewski, C.; Ioannidou, H. A.; ElMarrouni, A.; Nilewski, L. G.; Beabout, K.; Wang, T. T.; Shamoo, Y. J. Am. Chem. Soc. 2014, 136, 12137– 12160 DOI: 10.1021/ja506472u

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