Author(s): M. Latha, Sri Charitha Annam, M. Durga Bhavani, G. Ravi Kumar, M. Subba Rao

Email(s): mannamsrao@gmail.com

DOI: 10.52711/0974-360X.2024.00342   

Address: M. Latha1, Sri Charitha Annam2, M. Durga Bhavani3, G. Ravi Kumar4, M. Subba Rao5
1Dept. of Basic Science and Humanities, Dhanekula Institute of Engineering and Technology, Ganguru, Vijayawada - 521139, AP, India.
2Department of Humanities and Sciences, VNR Vignana Jyothi Institute of Engineering and Technology, Hyderabad. 500090, Telangana, India.
3Dept. of Chemistry, V.R. Siddhartha Engineering College, Kanuru, Vijayawada - 520 007, AP, India.
4Department of Chemistry, Govt. Degree College, Siddipet - 502103, Telangana (Dt), India.
5Dept. of Chemistry, University College of Sciences, Acharya Nagarjuna University, Guntur - 522510, AP, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
As part of this study, a new sensitive, convenient, accurate and robust reversed-phase high-performance liquid chromatography (RP-HPLC) method for the determination of azelidipine in pharmaceutical and tablet formulations was developed and validated. The three variables chosen were methanol concentration, flow rate, and pH in the mobile phase. Separation was performed using an HPLC method with a UV detector and a Chromosil C18 (250mm x 450mm). Methanol was pumped at a flow rate of 1.0mL/min and adjusted to pH 4.0 with dilute OPA (60:40% v/v) and pH 4.0 with potassium dihydrogen phosphate buffer (pH 4.0), 255nm.


Cite this article:
M. Latha, Sri Charitha Annam, M. Durga Bhavani, G. Ravi Kumar, M. Subba Rao. Design, Optimization, and Justification of RP-HPLC process for the Resolvation of Azelnidipine in bulk plus in Pharmaceutical Components. Research Journal of Pharmacy and Technology. 2024; 17(5):2175-9. doi: 10.52711/0974-360X.2024.00342

Cite(Electronic):
M. Latha, Sri Charitha Annam, M. Durga Bhavani, G. Ravi Kumar, M. Subba Rao. Design, Optimization, and Justification of RP-HPLC process for the Resolvation of Azelnidipine in bulk plus in Pharmaceutical Components. Research Journal of Pharmacy and Technology. 2024; 17(5):2175-9. doi: 10.52711/0974-360X.2024.00342   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-38


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