Author(s): Mohammad Reza Maghsoudi, Peyman khademhosseini, Zabihollah Talesh, Mehran Bahramian

Email(s): dr.maghsoudi.m@gmail.com

DOI: 10.52711/0974-360X.2024.00331   

Address: Mohammad Reza Maghsoudi1*, Peyman khademhosseini1, Zabihollah Talesh1, Mehran Bahramian2
1Department of Emergency Medicine, Faculty of Emergency Medicine and Toxicology, Alborz University of Medical Science, Karaj, Iran.
2Department of Emergency Medicine, Alborz University of Medical Science, Karaj, Iran.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
Introduction: The most common emergency of high blood pressure is a sudden increase in blood pressure despite continuing the prescribed treatments, in patients with a history of primary chronic blood pressure. The purpose of the present study investigate the effectiveness of anti-anxiety treatment in helping to control hypertension in hypertensive crises patients referred to Shahid Rajaei Hospital of Karaj in 2020. Materials and Methods: The present study is a randomized clinical trial. The study subjects included patients with hypertensive crisis who referred to Shahid Rajaei Medical and Teaching Center in Karaj in 2020. The information was collected using researcher-made questionnaires, Hospital Anxiety and Depression Scale (HADS), and the same device and operator for each patient. The patients were randomly divided into two groups (received Lorazepam 1mg and Olanzapine 2mg orally) and (did not receive anti-anxiety medication). The systolic, diastolic and heart rate of the patients during their stay in the hospital were evaluated in all patients with high blood pressure according to the monitoring standard of these symptoms, and in the patients of the anti-anxiety drug group, at the beginning of anti-anxiety drug administration and then 40 minutes after the prescription of anti-anxiety medication was also measured. After being discharged from the emergency room and taking the oral antihypertensive and anti-anxiety diet of their own group, the patients were called for re-evaluation one week and three weeks later. Results: In this study, 120 patients including 59 women and 61 men, with an average age of 52.24 years, were investigated. The results showed that the reduction of systolic and diastolic pressure is statistically significant compared to cases of not using anti-anxiety medication (P?0.05). However, in the follow-up i.e. 1 week and 3 weeks later, no significant difference was observed (P?0.05). Conclusion: The results of the present study showed that the evaluation of patients with hypertensive crisis in terms of anxiety disorder with an appropriate scale and the prescription of anti-anxiety drugs in patients with indicators of anxiety disorders during a hypertensive crisis help to improve and accelerate blood pressure control in the emergency room. It is suggested that more studies be designed with a longer duration and larger sample size in the future.


Cite this article:
Mohammad Reza Maghsoudi, Peyman khademhosseini, Zabihollah Talesh, Mehran Bahramian. Assessment of Anxiolytic Therapy efficiency in helping hypertension control in hypertensive crises in Rajaiee hospital patients, Karaj, 2020: A Randomized Clinical Trial. Research Journal of Pharmacy and Technology. 2024; 17(5):2093-8. doi: 10.52711/0974-360X.2024.00331

Cite(Electronic):
Mohammad Reza Maghsoudi, Peyman khademhosseini, Zabihollah Talesh, Mehran Bahramian. Assessment of Anxiolytic Therapy efficiency in helping hypertension control in hypertensive crises in Rajaiee hospital patients, Karaj, 2020: A Randomized Clinical Trial. Research Journal of Pharmacy and Technology. 2024; 17(5):2093-8. doi: 10.52711/0974-360X.2024.00331   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-27


REFERENCES:
1.    Bagheri-Saveh M.I, Dehvan F, Mahmoodi P. The Effect of Self-Management Program on Adherence to Treatment Regimen in Patients with Hypertension. Scientific Journal of Kurdistan University of Medical Sciences. 2023; 28(2):110-21.‏
2.    Girija M, Kokilavani N. Effectiveness of structured teaching programme on knowledge, attitude and practice among patients with hypertension. Asian Journal of Nursing Education and Research. 2014; 4(1): 136-9.‏
3.    Tarke S.R, Shanmugasundaram P. Formulation and evaluation of fast Dissolving tablets of Antihypertensive Drug. Research Journal of Pharmacy and Technology. 2017; 10(1): 155-60.‏ https://doi.org/10.5958/0974-360X.2017.00034.8
4.    Rahnmazadeh M, Ashaeri H, Ranjbaripour T, Kakavand A, Meschi F. Investigating the Effect of Beshiari-Based Stress Reduction Program on Depression, Ataxia and Blood Pressure in Patients with Coronary Heart Disease. Islamic Life Style. 2022; 6(2):390-402.
5.    Krungkraipetch N, Srirojanakul S, Sutthiopad N, Jongcherdchootrakul K. Incidence of cerebrovascular accident (CVA) and its factors among hypertensive patients in a community hospital setting in Thailand: a retrospective cohort study from 2011 to 2022. Population Medicine. 2023; 5(Supplement):1-12.https://doi.org/10.18332/popmed/165098
6.    Barbato E, Azizi M, Schmieder R.E, Lauder L, Böhm M, Brouwers S, Mahfoud F. Renal denervation in the management of hypertension in adults. A clinical consensus statement of the ESC Council on Hypertension and the European Association of Percutaneous Cardiovascular Interventions (EAPCI). European Heart Journal. 2023; 44(15): 1313-30.‏https://doi.org/10.1093/eurheartj/ehad054
7.    Tzourio C. Hypertension, cognitive decline, and dementia: an epidemiological perspective. Dialogues in clinical neuroscience. ‏2022; 9(1):61-70.https://doi.org/10.31887/DCNS.2007.9.1/ctzourio
8.    Law J.P, Pickup L, Pavlovic D, Townend J.N, Ferro C.J. Hypertension and cardiomyopathy associated with chronic kidney disease: epidemiology, pathogenesis and treatment considerations. Journal of Human Hypertension. 2023; 37(1):1-19.‏ https://doi.org/10.1038/s41371-022-00751-4
9.    Lawes C.M, Vander Hoorn S, Law M.R., Elliott P, MacMahon S, Rodgers A. Blood pressure and the global burden of disease 2000. Part II: estimates of attributable burden. Journal of hypertension. 2006; 24(3):423-30.‏https://doi.org/10.1097/01.hjh.0000199801.72563.6f
10.    Kitagawa K. Blood pressure management for secondary stroke prevention. Hypertension Research. 2022; 45(6):936-43.‏ https://doi.org/10.1038/s41440-022-00908-1
11.    Williams B, Mancia G, Spiering W, Rosei E.A, Azizi M, Burnier M, Desormais, I. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Kardiologia Polska (Polish Heart Journal). 2019; 77(2): 71-159.‏ https://doi.org/10.5603/KP.2019.0018
12.    Sheykh M, Ostadrahimi P, Havasian M.R, Rostami-Estabragh K, Mahmoodi Z. Evaluation of gender differences in the prevalence of coronary risk factors in patients with acute intractable syndrome hospitalized in CCU of Amir-Almomenin hospital, Zabol. Research Journal of Pharmacy and Technology. 2017; 10(9): 2883-6. ‏https://doi.org/10.5958/0974-360X.2017.00509.1
13.    Lim S.S, Vos T, Flaxman A.D, Danaei G, Shibuya K, Adair-Rohani H,  Pelizzari P.M. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012; 380(9859): 2224-60.‏ https://doi.org/10.1016/S0140-6736(12)61766-8
14.    Kearney P.M, Whelton M, Reynolds K, Muntner P, Whelton P.K. He J. Global burden of hypertension: analysis of worldwide data. The lancet. 2005; 365(9455): 217-23. https://doi.org/10.1016/S0140-6736(05)17741-1
15.    ‏Desta D.M, Wondafrash D.Z, Tsadik A.G, Kasahun G.G, Tassew S, Gebrehiwot T, Asgedom S.W. Prevalence of hypertensive emergency and associated factors among hospitalized patients with hypertensive crisis: A retrospective cross-sectional study. Integrated Blood Pressure Control. 2020; 13(1): 95-102.‏https://doi.org/10.2147/IBPC.S265183
16.    Rodriguez M.A, Kumar S.K, De-Caro M. Hypertensive crisis. Cardiol Rev. 2010; 18(2): 102-7. https://doi.org/10.1097/CRD.0b013e3181c307b7
17.    Marik P.E, Varon J. Hypertensive crises: challenges and management. Chest. 2007. 131(6):1949-62.https://doi.org/10.1378/chest.06-2490
18.    Whelton P.K, Carey R.M., Aronow W.S, Casey D.E, Collins K.J, Dennison Himmelfarb C, Wright J.T, 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2018; 71(19): e127-e248.https://doi.org/10.1161/HYP.0000000000000065
19.    Chobanian A.V. Bakris G.L, Black H.R, Cushman W.C, Green L.A, Izzo J.L. National High Blood Pressure Education Program Coordinating Committee. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003; 42(6): 1206-52. https://doi.org/10.1161/01.HYP.0000107251.49515.c2‏
20.    Katakam R, Brukamp K, Townsend R.R. What is the proper workup of a patient with hypertension?. Cleve Clin J Med. 2008; 75(9):663-72. https://doi.org/10.3949/ccjm.75.9.663
21.    Rivera S.L, Martin J, Landry J. Acute and chronic hypertension: what clinicians need to know for diagnosis and management.Crit Care NursClin North Am. 2019; 31(1):97-108. https://doi.org/10.1016/j.cnc.2018.11.008
22.    Williams B, Mancia G, Spiering W, AgabitiRosei E, Azizi M, Burnier M, Desormais I. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). European heart journal. 2018;  39(33): 3021-104.https://doi.org/10.1093/eurheartj/ehy686
23.    Archana S, Ram M. A Prospective Study on Assessment of Medication Adherence of Patients Towards Antihypersentive Medications. Research Journal of Pharmacy and Technology. 2017; 10(11): 3779-82.‏https://doi.org/10.5958/0974-360X.2017.00685.0
24.    Reeves W.C, Pratt L.A, Thompson W, Ahluwalia I.B, Dhingra S.S, McKnight-Eily L.R, Safran M.A. Mental illness surveillance among adults in the United States.‏ Morbidity and mortality weekly report. 2011; 60(1): 31627.
25.    McEvoy P. M, Grove R, Slade T. Epidemiology of anxiety disorders in the Australian general population: findings of the 2007 Australian National Survey of Mental Health and Wellbeing. Australian and New Zealand Journal of Psychiatry. 2011; 45(11) :957-67 .‏https://doi.org/10.3109/00048674.2011.624083
26.    Bacon S.L, Campbell T.S, Arsenault A, Lavoie K.L. The impact of mood and anxiety disorders on incident hypertension at one year. International Journal of Hypertension. 2014; 2014(1): 1-7.‏ https://doi.org/10.1155/2014/953094
27.    James D, Nazar N.  Role of anti-anxiety drugs in patient cooperation during minor surgical procedure. Research Journal of Pharmacy and Technology. 2018; 11(8): 3389-91. ‏https://doi.org/10.5958/0974-360X.2018.00624.8
28.    Maniero C, Lopuszko A, Papalois K.B, Gupta A, Kapil V, Khanji M.Y. Non-pharmacological factors for hypertension management: a systematic review of international guidelines. European Journal of Preventive Cardiology. 2023; 30(1): 17-33. ‏https://doi.org/10.1093/eurjpc/zwac163
29.    Yeswanthi S, Jayakumari S. A prospective study on combinational drug efficacy in hypertensive patients. Research Journal of Pharmacy and Technology. 2018; 11(2): 509-12.‏https://doi.org/10.5958/0974-360X.2018.00093.8
30.    Kwon M.J, Ahn S.Y. Factors affecting blood pressure control in elderly Koreans with hypertension. Research Journal of Pharmacy and Technology. 2018; 11(4): 1398-403.‏ https://doi.org/10.5958/0974-360X.2018.00261.5
31.    Stein D.J, Aguilar-Gaxiola S, Alonso J, Bruffaerts R, De Jonge P, Liu Z, Scott K.M. Associations between mental disorders and subsequent onset of hypertension. General hospital psychiatry. 2014; 36(2):142-9. ‏https://doi.org/10.1016/j.genhosppsych.2013.11.002
32.    Johannessen L, Strudsholm U, Foldager L, Munk-Jørgensen P. Increased risk of hypertension in patients with bipolar disorder and patients with anxiety compared to background population and patients with schizophrenia. J Affect Disord. 2006; 95(1-3): 13–7. https://doi.org/10.1016/j.jad.2006.03.027
33.    Ginty A.T, Carroll D, Roseboom T.J, Phillips A.C, de Rooij S.R. Depression and anxiety are associated with a diagnosis of hypertension 5 years later in a cohort of late middle-aged men and women. J Hum Hypertens. 2013; 27(3): 187–90.https://doi.org/10.1038/jhh.2012.18
34.    Wang W, Chair S.Y, Thompson D.R, Twinn S.F. A psychometric evaluation of the Chinese version of the Hospital Anxiety and Depression Scale in patients with coronary heart disease. J ClinNurs. 2009; 18(17): 2436-43.https://doi.org/10.1016/j.psym.2011.04.003
35.    Roozegar M.A, Nourmohammadi H, Havasian M, Seidkhani H, Jamdar S. Evaluation of Oral and Dental complications caused by Cyclophosphamide in patients with breast cancer in the Shahid-Mostafa Hospital, Ilam, 2019. Research Journal of Pharmacy and Technology. 2022; 15(12): 5517-20.‏https://doi.org/10.52711/0974-360X.2022.00931
36.    Otogara M, Babaei M, Abzadeh Z.A, Shabanpoor M, Havasian M.R, Rad S.H., Shayan A. The effect of communication skills training for medical personnel on patients’ satisfaction. Research Journal of Pharmacy and Technology. 2017; 10(11): 3951-6. https://doi.org/10.5958/0974-360X.2017.00717.X
37.    Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues in Clinical Neuroscience. 2015; 17(3): 327-35. https://doi.org/10.31887/DCNS.2015.17.3/bbandelow
38.    Bhagat V, Simbak N, Husain R, Mat K.C.A brief literature review retraining amygdala to substitute its irrational conditioned fear and anxiety responses with new learning experiences. Research Journal of Pharmacy and Technology. 2020; 13(8): 3987-91.‏ https://doi.org/10.5958/0974-360X.2020.00705.2
39.    Yagan M.B, White D, Staab J. Sedation of the mechanically ventilated patient. Critical Care Nursing Quarterly. 2000; 22(4): 90-100.
40.    Grimsrud A, Stein D.J, Seedat S, Williams D, Myer L. The association between hypertension and depression and anxiety disorders: results from a nationally-representative sample of South African adults. PLoS One. 2009; 4(5): e5552.https://doi.org/10.1371/journal.pone.0005552
41.    Hamer M, Batty G.D, Stamatakis E, Kivimaki M. Hypertension awareness and psychological distress. Hypertension. 2010; 56(3): 547–50.https://doi.org/10.1161/HYPERTENSIONAHA.110.153775
42.    Yilmaz S, Pekdemir M, Tural Ü, Uygun M. Comparison of alprazolam versus captopril in high blood pressure: a randomized controlled trial. Blood Pressure. 2011; 20(4): 239-43. https://doi.org/10.3109/08037051.2011.553934
43.    Herhaus B, Siepmann M, Kahaly G.J, Conrad R, Petrowski K. Effect of a biofeedback intervention on heart rate variability in individuals with panic disorder: A randomized controlled trial. Psychosomatic Medicine. 2022; 84(2): 199-209.‏ https://doi.org/10.1097/PSY.0000000000001031
44.    Al-Qudah B, Ahmed A.E, Alamin M, Aboolmaaly C, Shariff M. Abstract P257: Refractory Hypertension Partially Improved With Anxiolytics. Hypertension. 2021; 78(suppl_1): AP257.‏ https://doi.org/10.1161/hyp.78.suppl_1.P257
45.    Paštrović F, KrešimirOkštajner P, Vodanović M, Raos D, Jug J, LovrićBenčić M, Prkačin I. The Role of Anxiolytics in Hypertensive Urgency Management. Psychiatria Danubina. 2020; 32(suppl-4): 593-6.‏
46.    Pich E.M, Agnati L.F, Zini I, Marrama P, Carani C. Neuropeptide Y produces anxiolytic effects in spontaneously hypertensive rats. Peptides. 1993; 14(5): 909-12.‏ https://doi.org/10.1016/0196-9781(93)90065-O
47.    Komsiyska D, Penev M, Petrov D, Hristova M. The role of anxiolytics in the treatment of patients with arterial hypertension accompanied by anxiety disorders. Trakia Journal of Sciences. 2015; 13(2): 131-5.‏https://doi.org/10.15547/tjs.2015.s.02.027
48.    Kulkarni M.T, Holzman C, Wasilevich E, Luo Z, Scheid J, Allswede M. Pregnancy hypertension and its associations with pre-pregnancy depression, anxiety, antidepressants, and anxiolytics. Pregnancy Hypertension. 2019; 16(1): 67-74.‏ https://doi.org/10.1016/j.preghy.2019.03.003

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available