Author(s): Ashwin Porwal, Paresh Gandhi, Deepak Kulkarni, Gajanan Bhagwat, Pravin Kamble

Email(s): drashwinporwal@healinghandsclinic.co.in

DOI: 10.52711/0974-360X.2024.00328   

Address: Ashwin Porwal1*, Paresh Gandhi1, Deepak Kulkarni1, Gajanan Bhagwat2, Pravin Kamble2
1Healing Hands Clinic, Ground Floor, Millenium Star Extension Adjacent to Ruby Hall Entrance Gate, Dhole Patil Rd, Pune - 411001, Maharashtra, India.
2RandD Center, HealingHands and Herbs Pvt. Ltd., 101, Mangalmurti Complex, CTS No. 990, Shukrawar Peth, Tilak Road, Pune - 411002. Maharashtra, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
The main aim of the study was to evaluate the effect of anoac® cream treatment on the management of Haemorrhoids, Fissures and Fistulas in comparison with marketed ointment.It was a prospective, observational, open-label, comparative and single centre clinical study conducted on 60 Haemorrhoids, Fissures and Fistulas patients. Adult patients of either sex, 18 years or older, referred to the Healing Hands Clinic, Pune, India, for haemorrhoids, fissures and fistulas were study candidates. Some patients were given ananoac® cream treatment, while others were given marketed ointment. 60 patients were included and no side effects were reported during the entire study period. The anoac® cream treatment group exhibited a significant difference in symptoms with P values < 0.05. In contrast, the marketed ointment showed a very slight difference in symptoms, which was inferior to the anoac® treatment group. An examination of the proposed doctor and patients revealed that almost all patients in the anoac® cream treatment group made excellent progress when compared with the marketed ointment. This study concludes that the anoac® cream formulation provides more relief than the marketed ointment for treating haemorrhoids, fissures, and fistulas. It is also well-tolerated, safe, and effective.


Cite this article:
Ashwin Porwal, Paresh Gandhi, Deepak Kulkarni, Gajanan Bhagwat, Pravin Kamble. A Comparative Clinical Study of Anoac Cream with Marketed Ointment in patients with Haemorrhoids, Fissures and Fistulas. Research Journal of Pharmacy and Technology. 2024; 17(5):2071-6. doi: 10.52711/0974-360X.2024.00328

Cite(Electronic):
Ashwin Porwal, Paresh Gandhi, Deepak Kulkarni, Gajanan Bhagwat, Pravin Kamble. A Comparative Clinical Study of Anoac Cream with Marketed Ointment in patients with Haemorrhoids, Fissures and Fistulas. Research Journal of Pharmacy and Technology. 2024; 17(5):2071-6. doi: 10.52711/0974-360X.2024.00328   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-24


REFERENCES:
1.    Davies D. Bailey J. Diagnosis and Management of Anorectal Disorders in the Primary Care Setting. Prim Care. 2017; 44(4): 709-720. http://dx.doi.org/10.1016/j.pop.2017.07.012
2.    Gopal DV. Disease of the Rectum and Anus: A Clinical Approach to Common Disorders. Clinical Cornerstone. 2002; 4(4): 34-48. https://doi.org/10.1016/s1098-3597(02)90004-9
3.    Hall JF. Modern management of hemorrhoidal disease. Gastroenterol Clin North Am. 2013; 42(4): 759-772. https://doi.org/10.1016/j.gtc.2013.09.001
4.    Chong PS. Bartolo DC. Hemorrhoids and fissure in ano. Gastroenterol Clin North Am. 2008; 37(3): 627-644. https://doi.org/10.1016/j.gtc.2008.07.001
5.    Janicke DM. Pundt MR. Anorectal Disorders. Emergency Medicine Clinics of North America. 1996; 14(4): 757-788. https://doi.org/10.1016/s0733-8627(05)70278-9
6.    Johanson JF. Sonnenberg A. The Prevalence of Hemorrhoids and Chronic Constipation. Gastroenterology. 1990; 98(2): 380-386. https://doi.org/10.1016/0016-5085(90)90828-o
7.    Shubham M.C. Dhonde P. Avinash B.T. Pawan N.K. Time to think about Hemorrhoids. Research Journal of Pharmacology and Pharmacodynamics. 2020; 12(1): 39-46.
8.    Lohsiriwat V. Treatment of hemorrhoids: A coloproctologist’s view. World Journal of Gastroenterology. 2015; 21(31): 9245-9252. https://doi.org/10.3748/wjg.v21.i31.9245
9.    Jonas M. Scholefield JH. Anal Fissure. Gastroenterology clinics of North America. 2001; 30(1): 167-181. https://doi.org/10.1016/s0889-8553(05)70172-2
10.    Mazier WP. De Moraes RT. Dignan RD. Anal fissure and anal ulcers. The surgical clinics of North America. 1978; 58(3): 479-485.  https://doi.org/10.1016/s0039-6109(16)41531-8
11.    Lund JN. Scholefield J H. Aetiology and treatment of anal fissure. The British Journal of Surgery. 1996; 83(10): 1335-1344. https://doi.org/10.1002/bjs.1800831006
12.    Cross K L. Massey EJ. Fowler AL. Monson JR. The Management of Anal Fissure: ACPGBI Position Statement. Colorectal Dis. 2008; 10: 1-7. https://doi.org/10.1111/j.1463-1318.2008.01681.x
13.    Nottingham JM.Rentea RM. Anal Fistulotomy (Seton Placement). In: StatPearls. StatPearls Publishing, Treasure Island, FL. 2020. https://www.ncbi.nlm.nih.gov/books/NBK555998/
14.    Cirocchi R.Trastulli S. Morelli U.Desiderio J. Boselli C.Parisi A.Noya G. The treatment of anal fistulas with biologically derived products: is innovation better than conventional surgical treatment? An update. Tech Coloproctol. 2012; 17: 259-273. https://doi.org/10.1007/s10151-012-0948-9
15.    Phillips J. Lees N. Arnall F. Current management of fistula-in-ano. British Journal of Hospital Medicine 2015;76:142-147. https://doi.org/10.12968/hmed.2015.76.3.142
16.    Emile SH. Recurrent anal fistulas: When, why, and how to manage?. World J Clin Cases. 2020; 8(9): 1586-1591. https://doi.org/10.12998/wjcc.v8.i9.1586
17.    Rakinic J.Poola PV. Hemorrhoids and fistulas: new solutions to old problems. Current Problems in Surgery. 2014;51(3):98-137. https://doi.org/10.1067/j.cpsurg.2013.11.002
18.    Hashempur MH. Khademi F. Rahmanifard M. Zarshenas MM.An Evidence-Based Study on Medicinal Plants for Hemorrhoids in Medieval Persia. Journal of Evidence-based Complementary and Alternative Medicine. 2017; 22(4): 969-981. https://doi.org/10.1177/2156587216688597
19.    Porwal A. Kundu GC. Bhagwat G.Butti R. Herbal medicine AnoSpray suppresses proinflammatory cytokines COX-2 and RANTES in the management of hemorrhoids, acute anal fissures and perineal wounds. Exp Ther Med. 2022; 23(1): 86. https://doi.org/10.3892/etm.2021.11009
20.    Porwal A. Kundu GC. Bhagwat G.Butti R. Polyherbal formulation Anoac‑H suppresses the expression of RANTES and VEGF for the management of bleeding hemorrhoids and fistula. Mol Med Rep. 2021; 24(4): 736. https://doi.org/10.3892/mmr.2021.12376
21.    Porwal A. Kulkarni D. Gandhi P. Clinical Evaluation of Improved Anoac Cream for Efficacy and Adverse Drug Reaction in Patients with Perianal Symptoms due to Anal Fissure and Hemorrhoids. A Prospective Open Label Study. 2018; 4(8): 129-132.
22.    Gardner IH.Siddharthan RV.Tsikitis VL. Benign anorectal disease: hemorrhoids, fissures, and fistulas. Ann Gastroenterol. 2020; 33(1): 9-18. https://doi.org/10.20524/aog.2019.0438
23.    Amrutha K. Sekhar M.B. Vijey A.M. Prospective Study on the Quality of Life in Patients with Anorectal Disease. Research J. Pharm. and Tech. 2017; 10(1): 145-148.
24.    Acheson AG. Scholefield JH. Management of haemorrhoids. BMJ (Clinical Research Ed.) 2008; 336(7640): 380–383. https://doi.org/10.1136/bmj.39465.674745.80
25.    Firoz S, Rajasekaran S. A Survey on Mucoadhesive Thermoreversible Drug Delivery System with special Emphasis on Recto-Anal Region for the Treatment of Internal Hemorrhoids. Research J. Pharm. and Tech. 2021; 14(5): 2878-2886.
26.    Mullaicharam A.R. Uma R.M. Geetha K. Preetha S.P. Chandralekha V. Hemorrhoids: A Review. Research J. Pharm. and Tech. 2010; 3(2):296-299.
27.    Lorenzo-Rivero S. Hemorrhoids: Diagnosis and Current Management. The American Surgeon. 2009; 75(8): 635-642. https://doi.org/10.1177/000313480907500801
28.    Carapeti EA. Kamm MA. Evans BK.Phillips RK. Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects. Gut. 1999; 45(5): 719-722. https://doi.org/10.1136/gut.45.5.719
29.    Higuero T. Update on the management of anal fissure. Journal of Visceral Surgery. 2015; 152(2): S37-S43. https://doi.org/10.1016/j.jviscsurg.2014.07.007
30.    Phillips J. Lees N. Arnall F. Current management of fistula-in-ano. British Journal of Hospital Medicine (London, England: 2005). 2015; 76(3): 142-147. https://doi.org/10.12968/hmed.2015.76.3.142
31.    Kunitake H. Poylin V. Complications Following Anorectal Surgery. Clin Colon Rectal Surg. 2016; 29(1): 14-21. https://doi.org/10.1055/s-0035-1568145
32.    Amarprakash D. Archana K. Management of Gudarsh (Grade- 2 Internal Hemorrhoids) with ‘Kasisadi Taila-Matrabasti’ and HaritakiChurnaVati- A Case Study. Gis Science Journal. 2021; 8(1): 992-1001. https://www.researchgate.net/publication/348590109
33.    Alzohairy MA. Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Disease Prevention and Treatment. Evidence-Based Complementary and Alternative Medicine. 2016; 2016: 1-11. https://doi.org/10.1155/2016/7382506
34.    Meenakshi B.Manindar S. Lone GM. Kamal D. Comparative analysis of phytochemical, antibacterial and antioxidant activity of different extracts of azadirachtaindicaleaves. International Journal of Allied Medical Sciences and Clinical Research. 2020; 5(4): 970-978. https://ijamscr.com/ijamscr/article/view/472
35.    Sunanda R. Lakshmi T. Natural Remedies for Haemorrhoids and Bleeding Piles–An update. Research J. Pharm. and Tech. 2014; 7(2):253-254.
36.    Reshma C. Charmi P. Jitendriya P. Greener approach for copper nanoparticles synthesis from Catharanthus roseus and Azadirachta indica leaf extract and their antibacterial and antioxidant activities. Asian Journal of Research in Pharmaceutical Sciences. 2018; 8(2): 81-90.
37.    Purohit S.K. Solanki R. Soni R. Mathur V. Evaluation of Wound Healing Activity of Ethanolic Extract of  Azadirachta indica Leaves in Male Albino Rats. Asian J. Pharm. Tech. 2013; 3(2): 73-75.
38.    Abhijit R. Potential properties, used and scope of Azadirachtaindicain human health care. Research J.  Science and Tech. 2012; 4(2):55-58.
39.    Shailajan S. Menon S.Pednekar S. Singh A. Wound healing efficacy of JatyadiTaila: In vivo evaluation in rat using excision wound model. Journal of Ethnopharmacology. 2011; 138(1): 99-104. https://doi.org/10.1016/j.jep.2011.08.050
40.    Xiao S. Yu H. Xie Y. Guo Y. Fan J. Yao W. The anti-inflammatory potential of Cinnamomum camphora (L.) J.Presl essential oil in vitro and in vivo. Journal of Ethnopharmacology. 2021; 267: 113516. https://doi.org/10.1016/j.jep.2020.113516
41.    Remya M. Renuka K. A Comparative Study to Evaluate the Effect of Warm Mustard Oil Vs. Warm Mustard Oil with Camphor on Relief of Knee Joint Pain among Rural Women in Selected Areas of Puducherry. International Journal of Nursing Education and Research. 2014; 2(4):356-358.
42.    Atta AH.Alkofahi A. Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. Journal of Ethnopharmacology. 1998; 60(2): 117-124. https://doi.org/10.1016/s0378-8741(97)00137-2
43.    Hiral V. Sailaja I. Minimal Inhibitory Concentration and Minimal Bactericidal Concentration of Peppermint (Mentha piperita) extracts against standard microorganisms. Research J. Pharm. and Tech. 2021; 14(9): 4662-4666.
44.    Alok T. Comparative Evaluation of Pilex and Daflon in Hemorrhoids. The Antiseptic 2000; 97(9): 317-321. http://indianmedicine.eldoc.ub.rug.nl/id/eprint/6189
45.    Raj SH. Binod SK. Ram AY. Prashant SK. Shiva PM. A Critical Review on Management of Arsha (Hemorrhoids) In Ayurveda. AYUSHDHARA. 2019; 6(6): 2468-2472. https://doi.org/10.47070/ayushdhara.v6i6.505

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available