Author(s):
Denny Satria, Debi Dinha Octora, Mahatir Muhammad, Rosidah, Jansen Silalahi, Syukur Berkat Waruwu
Email(s):
dennysatria@usu.ac.id
DOI:
10.52711/0974-360X.2024.00325 
Address:
Denny Satria1*, Debi Dinha Octora2, Mahatir Muhammad1, Rosidah3, Jansen Silalahi4, Syukur Berkat Waruwu5
1Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
2Faculty of Pharmacy, Institut Kesehatan Medistra Lubuk Pakam, Deli Serdang, Indonesia.
3Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
5Faculty of Pharmacy and Health Sciences, Universitas Sari Mutiara Indonesia, Medan, Indonesia.
*Corresponding Author
Published In:
Volume - 17,
Issue - 5,
Year - 2024
ABSTRACT:
Hypercholesterolemia is strongly associated with elevated levels of total cholesterol, LDL cholesterol, triglycerides, and reduced HDL cholesterol levels. Disruption of the fat oxidation process can trigger fat accumulation in the liver. Liver disorders can be detected through an increase in liver enzymes, namely SGOT and SGPT, and an increase in the LDH enzyme, which can be used as a biomarker if there is damage to the liver or cell death, as well as increased ROS. ROS production causes a decrease in superoxide dismutase (SOD) activity. Saurauia vulcani Korth is a plant belonging to the Actinidiaceae family and commonly utilised in herbal medicine. Several studies show that Sauaria vulcani Korth has antihyperglycemic and antihyperlipidemic activity. This plant has several active ingredients, such as flavonoids, tannins, and saponins. Flavonoids can reduce total cholesterol levels, triglyceride levels and LDL levels. Extracts at doses of 50, 100, 200, 400 mg/KgBW with atorvastatin 0.80mg/KgBW were able to reduce levels of total cholesterol, LDL, triglycerides, SGOT, SGPT and increase HDL. At a dose of 200mg/KgBW, it can increase SOD and LDH levels. Ethanol extract of Saurauia vulcani Korth leaves has antihypercholesterolemic activity.
Cite this article:
Denny Satria, Debi Dinha Octora, Mahatir Muhammad, Rosidah, Jansen Silalahi, Syukur Berkat Waruwu. In vivo Analysis of Saurauia vulcani Korth. Leaves Extract as Antihypercholesterolemic. Research Journal of Pharmacy and Technology. 2024; 17(5):2051-5. doi: 10.52711/0974-360X.2024.00325
Cite(Electronic):
Denny Satria, Debi Dinha Octora, Mahatir Muhammad, Rosidah, Jansen Silalahi, Syukur Berkat Waruwu. In vivo Analysis of Saurauia vulcani Korth. Leaves Extract as Antihypercholesterolemic. Research Journal of Pharmacy and Technology. 2024; 17(5):2051-5. doi: 10.52711/0974-360X.2024.00325 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-21
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