Author(s): Aparna Desai, Ashish Pagariya, Monika Rathod, Kalyani Kayande, Mahavir Chhajed, Rushali Deokar, Sudhish Rai

Email(s): ashishpagariya@gmail.com

DOI: 10.52711/0974-360X.2024.00322   

Address: Aparna Desai1, Ashish Pagariya1, Monika Rathod1, Kalyani Kayande2, Mahavir Chhajed3, Rushali Deokar4, Sudhish Rai5
1Department of Pharmacognosy, Bhartiya Education Society’s Institute of Pharmacy, Velshet (Nagothane), Dist: Raigad.
2Department of Pharmaceutics, Sinhgad Institute of Pharmacy, Narhe, Pune, Maharashtra, India 411041.
3Vikrant Institute of Pharmacy and Science, Indore.
4Department of Pharmaceutics, Jaihind College of Pharmacy, Junnar, Pune.
5Jagrani Devi Pharmacy College, Baradwar, Shakti.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
The present work aimed to formulate and evaluate Besifloxacin Hydrochloride (HCl) ophthalmic in situ gel for conjunctivitis, based on temperature triggered gelation system to increase ocular residence time, bioavailability and patient compliance. Different formulations were prepared by using Poloxamer 407 and Poloxamer 188 as temperature sensitive as well as mucoadhesive polymers. Design expert software version 11 was used to optimized the formula. Optimized batch having Poloxamer 407 (24.80% w/v) and Poloxamer 188 (14.53% w/v) was evaluated for visual appearance, clarity, gelation temperature, gelling capacity, rheological property, ex vivo, in vitro release and accelerated stability studies. Histopathological study was carried out using Goat cornea and revealed no change in histopathology of the tissues. Formulation was found to be effective against the Escherichia coli and Staphylococcus aureus. Cumulative % drug release of Besifloxacin HCl ophthalmic in situ gel after 8 hours was found to be 96.47 %.


Cite this article:
Aparna Desai, Ashish Pagariya, Monika Rathod, Kalyani Kayande, Mahavir Chhajed, Rushali Deokar, Sudhish Rai. Besifloxacin HCl Ophthalmic In situ Gel: Design, Optimization, In vitro and Ex vivo Investigation. Research Journal of Pharmacy and Technology. 2024; 17(5):2035-9. doi: 10.52711/0974-360X.2024.00322

Cite(Electronic):
Aparna Desai, Ashish Pagariya, Monika Rathod, Kalyani Kayande, Mahavir Chhajed, Rushali Deokar, Sudhish Rai. Besifloxacin HCl Ophthalmic In situ Gel: Design, Optimization, In vitro and Ex vivo Investigation. Research Journal of Pharmacy and Technology. 2024; 17(5):2035-9. doi: 10.52711/0974-360X.2024.00322   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-18


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