Author(s): Selsia D, Vasantharaja R, Durga C, Subramanian S

Email(s): subbu3j@gmail.com

DOI: 10.52711/0974-360X.2024.00321   

Address: Selsia D, Vasantharaja R, Durga C, Subramanian S*
Department of Pharmaceutics, PSG College of Pharmacy, Peelamedu, Coimbatore – 641004, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
The aim of the present study is development and characterization of SNEDDS to enhance the bioavailability of anti-hyperlipidemic agent Atorvastatin calcium. The solubility was estimated in various solvent to find maximum solubility of drug in solvent. Vegetable oil (as vehicle), non-ionic surfactant (as surfactant, co-surfactant) and water is used to construct pseudo-ternary phase diagram (identify nanoemulsifying region). Stability, dispersibility and robustness to dilution to be performed for optimize formulations using phase diagram. Different formulations are prepared with various composition of vegetable oil, non-ionic surfactant. At one globule size of optimized system is expected to accept nano emulsion size range for improving the dissolution of Atorvastatin calcium. There by we may enhance the bio-availability of Atorvastatin.


Cite this article:
Selsia D, Vasantharaja R, Durga C, Subramanian S.. Self Nanoemulsifying Solid of Atorvastatin Calcium – Development, Characterization and Evaluation. Research Journal of Pharmacy and Technology. 2024; 17(5):2031-4. doi: 10.52711/0974-360X.2024.00321

Cite(Electronic):
Selsia D, Vasantharaja R, Durga C, Subramanian S.. Self Nanoemulsifying Solid of Atorvastatin Calcium – Development, Characterization and Evaluation. Research Journal of Pharmacy and Technology. 2024; 17(5):2031-4. doi: 10.52711/0974-360X.2024.00321   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-17


REFERENCE:
1.    Kuralarasan K, Subramanian S. Influence of Different Stabilizers on Dissolution of Cilnidipne Nanosupension. Asian Journal of Pharmaceutics. 2020; 14 (1): 26. DOI: https://doi.org/10.22377/ajp.v14i1.3472
2.    Subramanian S. Codestm drug delivery: design and evaluation of metronidazole tablets. International Journal Green Pharmacy. 2021; 15 (4): 400-405. DOI: https://doi.org/10.22377/ijgp.v15i4.3187
3.    Subramanian S, Monisha V. Investigating the use of liquisolid compact technique for pioglitazone HCI. Research Journal of Pharmacy and Technology. 2022; 15(3): 1013-7. DOI : 10.52711/0974-360X.2022.00169
4.    Bhairav B.A., J.K. Bachhav, R.B. Saudagar. Review on Solubility Enhancement Techniques. Asian J. Pharm. Res. 2016; 6(3): 147-152.
5.    Hiral A. Makadia, Ami Y. Bhatt, Ramesh B. Parmar, Ms. Jalpa S. Paun, H.M. Tank. Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects. Asian J. Pharm. Res. 2013; 3(1): 20-26.
6.    Wadhwa J, Nair A, Kumria R. Emulsion forming drug delivery system for lipophilic drugs. Acta Pol Pharm. 2012; 69(2):179-91. PMID: 22568032.
7.    Singh B, Khurana L, Bandyopadhyay S, Kapil R, Katare OO. Development of optimized self-nano-emulsifying drug delivery systems (SNEDDS) of carvedilol with enhanced bioavailability potential. Drug Deliv. 2011; 18(8): 599-612. DOI: 10.3109/10717544.2011.604686. Epub 2011 Oct 18. PMID: 22008038.
8.    Thomas N, Holm R, Müllertz A, Rades T. In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS). J Control Release. 2012 May 30; 160(1): 25-32. DOI: 10.1016/j.jconrel.2012.02.027. Epub 2012 Mar 3. PMID: 22405903.
9.    Pandurang N Dhabale, Vijay Jadhav, Chandrakant Raut. UV-Spectrophotometric Estimation of Atorvastatin Calcium in Tablet Dosage Form. Asian J. Research Chem. 2010; 3(2): 339-341.
10.    Mandal S, Mandal SS, Sawant KK. Design and development of microemulsion drug delivery system of atorvastatin and study its intestinal permeability in rats. International Journal of Drug Delivery. 2010; 2(1). DOI:10.5138/ijdd.2010.0975.0215.02014
11.    Patel J, Patel A, Raval M, Sheth N. Formulation and development of a self-nanoemulsifying drug delivery system of irbesartan. Journal of advanced pharmaceutical technology and research. 2011; 2(1): 9. DOI: 10.4103/2231-4040.79799
12.    Ponnaganti H, Abbulu K. Enhanced dissolution of repaglinide: SMEDDS formulation and in-vitro evaluation. Research Journal of Pharmacy and Technology. 2014; 7(11): 1246-52.
13.    Beg S, Swain S, Singh HP, Patra CN, Rao MB. Development, optimization, and characterization of solid self-nanoemulsifying drug delivery systems of valsartan using porous carriers. Aaps Pharmscitech. 2012; 13: 1416-27.
14.    Khan F, Islam MS, Jalil RU. Study of Solubility of Atorvastatin using Ternary Phase Diagram for the Development of Self-Emulsifying Drug Delivery Systems (SEDDS). Dhaka University Journal of Pharmaceutical Sciences. 2012; 11(2): 3-91.
15.    Doaa Elsegaie. Formulation and In-vitro Characterization of Self Nano-emulsifying Drug Delivery System (SNEDDS) for enhanced Solubility of Candesartan Cilexetil. Research J. Pharm. and Tech. 2019; 12(6): 2628-2636. DOI: 10.5958/0974-360X.2019.00440.2
16.    Patil P, Mahajan VR. Self-Emulsifying Drug Delivery Systems (SEDDS): A Brief Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2014; 6(2): 134-9. DOI: 10.3390/ph15091064
17.    Jyothi BJ, Sreelakshmi K. Design and evaluation of self-nanoemulsifying drug delivery system of flutamide. Journal of young pharmacists. 2011; 3(1): 4-8.
18.    Reddy MS, Sravani B. Formulation and evaluation of solid self nano emulsifying drug delivery system of olanzapine to enhance aqueous solubility and dissolution rate. Asian Journal of Pharmaceutical Research. 2021; 11(4): 227-38. DOI: 10.52711/2231-5691.2021.00040
19.    Venkatesh M, Mallesh K. Self-nano emulsifying drug delivery system (SNEDDS) for oral delivery of atorvastatin-formulation and bioavailability studies. Journal of Drug Delivery and Therapeutics. 2013; 3(3): 131-40.
20.    Chandrakar A, Sahu B, Sahu H, Dewangan J, Kumar N, Singh R, et al. Review on the formulation considerations needed to produce a stable Self micro Emulsifying Drug Delivery System (SMEDDS). Research Journal of Pharmacy and Technology. 2017; 10(5): 1563-70. DOI: 10.5958/0974-360X.2017.00275.X.
21.    Nan Z, Lijun G, Tao W, Dongqin Q. Evaluation of carbamazepine (CBZ) supersaturatable self-microemulsifying (S-SMEDDS) formulation in-vitro and in-vivo. Iranian journal of pharmaceutical research. 2012; 11(1): 257.
22.    Tripathi S, Kushwah V, Thanki K, Jain S. Triple antioxidant SNEDDS formulation with enhanced oral bioavailability: Implication of chemoprevention of breast cancer. Nanomedicine: Nanotechnology, Biology and Medicine. 2016 Aug 1; 12(6): 1431-43. DOI: 10.1016/j.nano.2016.03.003
23.    Uddin MS, Millat MS, Siddiqui SA. Formulation and evaluation studies of Atorvastatin calcium sustained release tablet. PharmaTutor. 2019 Sep 1; 7(9): 1-5.
24.    Rahul P. Jadhav, Vikranti W. Koli, Amruta B. Kamble, Dr. Mangesh A. Bhutkar. A Review on Nanoemulsion. Asian J. Res. Pharm. Sci. 2020; 10(2): 103-108. DOI: 10.5958/2231-5659.2020.00020.X
25.    Kumar DV, Jat RK, Kumar GV. Formulation and In-vitro Evaluation of Floating Drug Delivery System for Piretanide. International Journal of Pharmaceutical Research (09752366). 2020; 12(4). DOI: 10.31838/ijpr/2020.12.04.712
26.    Namayandeh SM, Kaseb F, Lesan S. Olive and sesame oil effect on lipid profile in hypercholesterolemic patients, which better?. Int J Prev Med. 2013; 4(9): 1059-62. PMID: 24130948; PMCID: PMC3793488.
27.    Debjit Bhowmik, Amerandra singh, Praveen Khirwadker, Nishu Shukla, et al. Formulation andamp; Evaluation of Methyl Phaenidate Sustained Release Tablets. Res J.Pharm. Dosage Formandamp; Tech. 2016; 8(3): 199-206. DOI: 10.5958/0975-4377.2016.00027.6


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available