Author(s): Ismail Bennani, Lamyae Yachi, Ali Cherif Chefchaouni, Youssef Hafidi, Badreddine Moukafih, Soufiane El Marrakchi, Fatima-Zahra Bandadi, Aicha Fahry, Yassir El Alaoui, Mustapha Bouatia, Abdelkader Laatiris, Nawal Cherkaoui, Abdeslam El Kartouti, Younes Rahali

Email(s): Email ID Not Available

DOI: 10.52711/0974-360X.2024.00316   

Address: Ismail Bennani1,2, Lamyae Yachi3,4, Ali Cherif Chefchaouni3,4, Youssef Hafidi2, Badreddine Moukafih1,2, Soufiane El Marrakchi1,2, Fatima-Zahra Bandadi1,2, Aicha Fahry3, Yassir El Alaoui3,4, Mustapha Bouatia3,4, Abdelkader Laatiris3, Nawal Cherkaoui3, Abdeslam El Kartouti1, Younes Rahali3,4
1Department of Pharmacy, Faculty of Medicine, Pharmacy and Dental Medicine of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
2Department of Pharmacy, Hassan II University Hospital of Fez, Morocco.
3Faculty of Medicine and Pharmacy, Mohammed V University of Rabat, Rabat, Morocco.
4IbnSina University Hospital Center, Rabat, Morocco.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
The solubilization of insoluble or poorly water-soluble drugs is one of the major factors taken into account in the formulation of oral solutions and parenteral forms. The goal of this study is to evaluate the utility of mixture design in enhancement water solubility of Albendazole by the use of phospholipids and nonionic surfactants that are well tolerated by the parenteral route.in this work, a design of experiments approach was tested using a mixture design of nonionic surfactants (tween® 80 and Solutol® HS 15), A phospholipid (Lipoid® S75) and Albendazole. Solubility determination was based on the analysis of samples absorbance at 308nm. A particles size measurement was conducted using a dynamic light scattering at the point showing the maximum of solubility. these experiments show an improving of solubility, up to 90% with runs 1, 3 and 6 compared to the solubility of albendazole in water, without excipients, examined by run 7. Indeed, the analysis of the design space showed that the solubility of albendazole is affected by the association of tween® 80, Solutol® HS 15 and Lipoid® S75. Run 3 containing 1% of albendazole, 1,5% of tween® 80, 1, 5% of Solutol® HS 15 and 0,38% of Lipoid® S75 and water q.s. for 100% w/w improved albendazole solubility by about 90%, and showed an average particles size of 11nm.


Cite this article:
Ismail Bennani, Lamyae Yachi, Ali Cherif Chefchaouni, Youssef Hafidi, Badreddine Moukafih, Soufiane El Marrakchi, Fatima-Zahra Bandadi, Aicha Fahry, Yassir El Alaoui, Mustapha Bouatia, Abdelkader Laatiris, Nawal Cherkaoui, Abdeslam El Kartouti, Younes Rahali. Solubilization Improvement using Non-Ionic Surfactants and Phospholipids Optimized by An Experimental Design: Case of Albendazole. Research Journal of Pharmacy and Technology. 2024; 17(5):1995-0. doi: 10.52711/0974-360X.2024.00316

Cite(Electronic):
Ismail Bennani, Lamyae Yachi, Ali Cherif Chefchaouni, Youssef Hafidi, Badreddine Moukafih, Soufiane El Marrakchi, Fatima-Zahra Bandadi, Aicha Fahry, Yassir El Alaoui, Mustapha Bouatia, Abdelkader Laatiris, Nawal Cherkaoui, Abdeslam El Kartouti, Younes Rahali. Solubilization Improvement using Non-Ionic Surfactants and Phospholipids Optimized by An Experimental Design: Case of Albendazole. Research Journal of Pharmacy and Technology. 2024; 17(5):1995-0. doi: 10.52711/0974-360X.2024.00316   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-12


REFERENCES:
1.    Pourgholami MH, Woon L, Almajd R, Akhter J, Bowery P, Morris DL. In vitro and in vivo suppression of growth of hepatocellular carcinoma cells by albendazole. Cancer Lett. 2001 ; 165 :43–49.https://doi.org/10.1016/s0304-3835(01)00382-2
2.    Gandla K, Lalitha R, Bommakanti S, Suthakaran R, Pallavi K. Development and Validation of RP-HPLC Method for Simultaneous Estimation of Albendazole and Praziqantel in Tablet Dosage Form. Asian Journal of Pharmaceutical Analysis 2015;5(3):115-8.https://doi.org/10.5958/2231-5675.2015.00018.6
3.    Vinarov Z, Gancheva G, Katev V, Tcholakova S S. Albendazole solution formulation via vesicle- to-micelle transition of phospholipid-surfactant aggregates. Drug DevInd Pharm.2018;44(7):1130-38.https://doi.org/10.1080/03639045.2018.1438461
4.    Fulop V, Jakab G, Bozo T et al. Study on the dissolution improvement of albendazole using reconstitutable dry nanosuspension formulation. Eur J Pharm Sci. 2018 ; 123 : 70-78.https://doi.org/10.1016/j.ejps.2018.07.027
5.    Hajare, AA, Jadhav, PR. Improvement of solubility and dissolution rate of indomethacin by solid dispersion in polyvinyl pyrrolidone K30 and poloxomer 188. Asian Journal of Pharmacy and Technology.2012 ;2(3):116-122
6.    M. H. Markad, S. D. Mankar. Review on: Solubility Enhancement of Poorly Water Soluble Drugs. Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(3):231-8. https://doi.org/10.22377/ajp.v1i1.734
7.    Raval AJ, Patel, MM. Techniques to Improve Bioavailability of Poorly Water Soluble Drugs–A review. Research Journal of Pharmaceutical Dosage Forms and Technology.2011;3(5):183-192.
8.    Torrado S, Lopez ML, Torrado G, Bolas F, Torraso S, Cadorniga R. A novel formulation of 15 albendazolesolution : oral bioavailability and efficacy evaluation. Int J Pharm. 1997 ; 156 :181–7
9.    Meena AK, Sharma K, Kandaswamy M, Rahagopal S, Mullangi R. Formulation development of an albendazole self-emulsifying drug delivery system (SEDDS) with enhanced systemic exposure. Acta Pharm. 2012; 62:563–80. https://doi.org/10.2478/v10007-012-0031-0
10.    El-Badry M, Fetih G, Salem-Bekhet M, Shakeel F. Formulation and evaluation of nanosuspension of albendazole for dissolution enhancement. NanosciNanotechnolLett. 2013;5 :1024–29. http://dx.doi.org/10.1166/nnl.2013.1645
11.    Li H, Song T, Qin Y, Liu W, li X, Shao Y et al. Efficiency of liposomal albenda- zole for the treatment of the patients with complex alveolar echinococcosis: a comparative analysis of CEUS, CT, and PET/CT. Parasitol Res. 2015 ; 114 :4175–80. https://doi.org/10.1007/s00436-015-4649-y
12.    Kang BS, Lee SE, Ng CL, Kim JK, Park JS. Exploring the preparation of albendazole-loaded chitosan-tripolyphosphate nanoparticles. Materials (Basel). 2015; 8(2) : 486–98. https://doi.org/10.3390/ma8020486
13.    Garcia JJ, Bolas F, Torrado JJ. Bioavailability and efficacy characteristics of two different oral liquid formulations of albendazole. Int J Pharm. 2003 ; 250 (2) : 351–58. https://doi.org/10.1016/s0378-5173(02)00559-8
14.    Del Estal JL, Alvarez AI, Villaverde C, Justel A, Prieto JG. Increased systematic bioavailability of albendazol when administered with surfactants in rat. Int J Pharm. 1994, 102 (1-3) :257–60.https://doi.org/10.1016/0378-5173(94)90063-9
15.    Helenius A, Simons K. Solubilization of membranes by detergents. BiochimBiophys 13 Act.1975 ; 415 (1), 29-79. https://doi.org/10.1016/0304-4157(75)90016-7
16.    El Alaoui Y, Sefrioui R, Bensouda Y, Rahali Y. Solubilization of acetaminophen using phospholipids and nonionic surfactants optimized by experimental design. J. Chem. Pharm. Res. 2014;6 (7):39-46.
17.    Sefrioui R, Y El Alaoui, M Bouatia, N cherkaoui, A Laatiris, Y Rahali. The use of nonionic surfactants and phospholipids to increase the solubility of ibuprofen optimzed by experimental design. J. Chem. Pharm. Res. 2015 ;7(5) :848-854.
18.    Enneffah W, El Wartiti MA, Bouatia M, Laatiris A, Cherkaoui N, Rahali Y. Solubilization of celecoxib using organic cosolvent and nonionic surfactants optimized by experimental design. Int. J. Pharm. Pharm Sci. 2016;8(3):161-6.
19.    Bakshi M.S, Singh J, Kaur G. Fluorescence study of solubilization of l-αdilauroylphosphatidylethanolamine in the mixed micelles with monomeric and dimeric cationic surfactants. J PhotochemPhotobiol A Chem. 2005 ; 173(2) : 202-210. https://doi.org/10.1016/j.chemphyslip.2005.08.005
20.    Bakshi, M.S, Singh K, Kaur G. Mixed micelles of monomeric and dimeric cationic surfactants with phospholipides : effect of hydrophobic interactions. Chemphys lipids. 2005 ; 138(1-2) : 81-92.
21.    Pattewar SV. Solubility Enhancement of Poorly Aqueous Soluble Drug-Simvastatin by Using Chitosan. Research Journal of Pharmaceutical Dosage Forms and Technology 2012, 4(1), 56-61.
22.    Deshpande M, Chandrashekhara S, Nagesh C, Patel M, Patel S, Majethiya V. Enhancement of Solubility of Trimethoprim IP by Using Different Surfactants. Research Journal of Pharmaceutical Dosage Forms and Technolog 2012, 4(1), 48-51.
23.    Khan MA. Enhancement of solubility of poorly water soluble drugs diclofenac sodium by mixed solvency approach. Research Journal of Pharmaceutical Dosage Forms and Technology 2013, 5(1), 39-41.
24.    Shah RR, Jadhav A, Vakhariya RR. Bicalutamide Tablets by Spray Dried Microspheres: An Approach to Enhance Solubility. Research Journal of Pharmaceutical Dosage Forms and Technology.2017;9(4):168-72.https://doi.org/10.5958/0975-4377.2017.00027.1
25.    Kanoujia K, Dewangan C, Masih A, Alexander A. Self Microemulsifying Drug Delivery System (SMEDDS): A Novel Approach to Improve the Therapeutic Efficacy of Orally Administered Drug. Research Journal of Pharmaceutical Dosage Forms and Technology.2018;10(2):95-102.https://doi.org/10.5958/0975-4377.2018.00015.0
26.    Jagtap VA, Talele AN, Bendale AR, Narkhede S, Jadhav A, Vidyasagar G. Solubility Enhancement of Pioglitazone by Using Poloxamer (188 and 407) with the Help of Kneading Method. Research Journal of Pharmacy and Technology 2010;3(4):1152-57.
27.    Myers RH, Montgomery DC, Anderson-Cook CM. Response surface methodology, process and producet optimization using design experiment, 3 Ed. Wiley, New York 2009
28.    Hadj sadok A, Moulai-Mostefa N, Bouda A. Etude de l'influence des facteurs de formulation sur les propriétés viscoélastiques d'un gel à base de carbopol. Rev Sci Technol. 2013 ;Synthèse 26 : 96-102.
29.    Su QJ, Mo T, Liu L, Pan HC, Deng B, Liu H. Paclitaxel-loaded Kolliphor® HS15/Polysorbate 80-mixed nano micelles : formulation, in vitro characterization and safety evaluation. Lat Am J Pharm. 2015 ; 34 : 702-11.
30.    Torrealba V, Johns RT. Coupled interfacial tension and phase behavior model based on micellar curvatures. J Am Chem Soc. Langmuir. 2017 ; 33 :13604–14.https://doi.org/10.1021/acs.langmuir.7b03372

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available