Author(s): Soumyajit Haldar, Anumita Saha, Mrityunjoy Majumdar, Sumit Paul, Monit Paul, Sourav Roy, Bappa Mukhopadhyay, Prodip Roy

Email(s): prodiproy19951228@gmail.com

DOI: 10.52711/0974-360X.2024.00315   

Address: Soumyajit Haldar1, Anumita Saha1, Mrityunjoy Majumdar1, Sumit Paul1, Monit Paul2, Sourav Roy1, Bappa Mukhopadhyay3, Prodip Roy1*
1Department of Pharmacology, Netaji Subhas Chandra ose Institute of Pharmacy, Roypara, Chakdaha, Nadia, 741222, West Bengal, India.
2Department of Pharmaceutical Chemistry, Netaji Subhas Chandra Bose Institute of Pharmacy, Roypara, Chakdaha, Nadia, 741222, West Bengal, India.
3N. P. Dutt and Son, 55, Pramanick Ghat road, Kolkata-700036.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
In this study we have evaluated the preclinical observation of the Force Drop on the mature male albino rats. The Force Drop is the product of N. P. Dutt and Son, Kolkata, in this product have many herbal plants with their androgenic activity. Mainly we have compared this product with the activity of testosterone. We have used testosterone in this study as a standard drug or chemical. In this study we have grouped the all animals in 4 and each group has 6 animals, there are one untreated, treated with testosterone or standard group, another two groups are low dosed Force Drop treated group and last one is higher dosed Force Drop treated group. The study has shown that the animals of standard group increased the dry weight of androgen sensitivity tissues and overall body weight and the animals of treated groups or Force Drop Ptreated groups increased the dry weight of sensitivity tissues and overall body weight but lesser the testosterone treated group and more than untreated group. But the lower dosed Force Drop Ptreated group increased weight of androgen sensitivity tissues and body weight which are less than higher dosed Force Drop treated animal group and more than untreated group. And the higher dosed Force Drop treated animals group increased weight much more than the untreated group of animals and lower than standard group or testosterone treated group.


Cite this article:
Soumyajit Haldar, Anumita Saha, Mrityunjoy Majumdar, Sumit Paul, Monit Paul, Sourav Roy, Bappa Mukhopadhyay, Prodip Roy. Preclinical Evaluation of a Homeo Formulation ‘Force Drop’ for its androgenic activity. Research Journal of Pharmacy and Technology. 2024; 17(5):1991-4. doi: 10.52711/0974-360X.2024.00315

Cite(Electronic):
Soumyajit Haldar, Anumita Saha, Mrityunjoy Majumdar, Sumit Paul, Monit Paul, Sourav Roy, Bappa Mukhopadhyay, Prodip Roy. Preclinical Evaluation of a Homeo Formulation ‘Force Drop’ for its androgenic activity. Research Journal of Pharmacy and Technology. 2024; 17(5):1991-4. doi: 10.52711/0974-360X.2024.00315   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-5-11


REFERENCES:
1.    Freyberger A, Ellinger-Ziegelbauer H, Krötlinger F.et al. Evaluation of the rodent Hershberger bioassay: testing of coded chemicals and supplementary molecular-biological and biochemical investigations. Toxicology. 2007 Sep 24;239(1-2):77-88. doi:10.1016/j.tox.2007.06.093
2.    Lizneva D, Gavrilova-Jordan L, Walker W, et al. Androgen excess: investigations and management. Best Practice and Research Clinical Obstetrics and Gynaecology. 2016 Nov; 1(37): 98-118. doi: 10.1016/j.bpobgyn.2016.05.003
3.    Soto AM, Calabro JM, Prechtl NV, Yau AY, Orlando EF, Daxenberger A, Kolok AS, GuilletteJr LJ, Le Bizec B, Lange IG, Sonnenschein C, et al. Androgenic and estrogenic activity in water bodies receiving cattle feedlot effluent in Eastern Nebraska, USA. Environmental health perspectives. 2004 Mar; 112(3):346. doi: 10.1289/ehp.6590
4.    Moon HJ, et al OECD validation of phase 3 Hershberger assay in Korea using surgically castrated male rats with coded chemicals. Journal of Applied Toxicology. 2009 May 1; 29(4):350-355.doi: 10.1002/jat.1418
5.    Carlson, Neil. Physiology of Behavior. Reproductive Behavior. 11th edition. Pearson.2012.
6.    Kazemi P, et al. Androgenic Effect of Origanum vulgarel L.spp viride extract on Hormone Level of Pituitary - gonadal Axis in Mature Male Vistar Rats. J Arak Uni Med Sci. 2012; 14 (6) :89-96
7.    Estrada-Reyes R, et al. Turnera diffusa Wild (Turneraceae) recovers sexual behavior in sexually exhausted males. Journal of Ethnopharmacology. 2009Jun25; 123(3): 423-9. doi:10.1016/j.jep.2009.03.032
8.    Kumar DJ, Sonia K, Madhan R, Selvakumar K, PT K. Antiyeast, antioxidant and anticancer activity of Tribulus terrestris Linn and Bougainvillea spectabilis Linn. Research Journal of Pharmacy and Technology. 2011;4(9):1483-1489.
9.    Abdulqawi LN, Quadri SA. Evaluation of Antibacterial and Antioxidant activities of Tribulus terrestris L. Fruits. Research Journal of Pharmacy and Technology. 2021;14(1):331-336.doi: 10.5958/0974-360X.2021.00061.5
10.    Sex medicines list in homeopathy for firm erection, longer duration - Page 2 of 2 [Internet]. Homeopathy Remedies Online. 2022 [cited 11 March 2022]. Available from: https://homeomart.net/2016/06/13/sex-medicines-list-homeopathy-for-firm-erection-longer-duration/2/
11.    MD(Ayu) D. Horse Gram Uses, Recipes, Dose, Side Effects [Internet]. Easy Ayurveda. 2022 [cited 11 September 2022]. Available from: https://www.easyayurveda.com/2016/02/29/horse-gram-uses-recipes-side-effects/#uses
12.    Khayatnouri M, et al. The effect of saffron orally administration on spermatogenesis index in rat. Adv Environ Biol. 2011 Jun 1; 5(7):1514-21.
13.    Kour P, Tiwari A. Medicinal Values of Secondary metabolites of Withania somnifera. Research journal of Pharmacy and Technology. 2018; 11(7): 3167-70.doi: 10.5958/0974-360X.2018.00582.6
14.    Nasimi Doost Azgomi R, et al. Effects of Withania somnifera on reproductive system: a systematic review of the available evidence. BioMed Research International. 2018 Jan 24; 2018:1-17. doi:10.1155/2018/4076430
15.    Vasavan SS, Sivanesan S, Jagadesan V. Antiperoxidative effect of Withania somnifera on lipid peroxidation and antioxidant capacity in the serum of nandrolone decanoate treated rats. Research Journal of Pharmacy and Technology. 2021 Feb 1; 14(2): 1065-8. doi:10.5958/0974-360X.2021.00191.8.
16.    SBL Salix Nigra Mother Tincture Q: Find SBL Salix Nigra Mother Tincture Q Information Online | Lybrate [Internet]. Lybrate. 2022 [cited 11 September 2022]. Available from: https://www.lybrate.com/otc/sbl-salix-nigra-mother-tincture-q
17.    Chevallier A. Encyclopedia of Herbal Medicine. Dorling Kindersley.2000
18.    Saul S. Effects of vitex agnes castus on hormonal imbalances in Polycystic Ovary Syndrome. Int J Basic Clin Pharmacol. 2017; 6(8): 2015-55.doi: 10.18203/2319-2003.ijbcp20173295.
19.    Saka VP,  et al. Effect of avena sativa (Oats) on spermatogenesis and reproductive health. Journal of Endocrinology and Reproduction. 2016; 20(2): 118-25.doi:10.18311/jer/2016/15471
20.    Rashid M, et al. Consumption of pure oats by individuals with celiac disease: a position statement by the Canadian Celiac Association Can J Gastroenterol. 2007 Oct; 21(10): 649–651 .doi:10.1155/2007/34059
21.    Owens W,  et al. The OECD program to validate the rat uterotrophic bioassay. Phase 2: dietary phytoestrogen analyses. Environmental health perspectives. 2003 Sep; 111(12): 1559–1567. doi: 10.1289/ehp.5949
22.    Saha K, Sen T, Majumdar M, Das H, Baisya O. Evaluation of Hydro-alcoholic extract of Corchorus capsularis seeds for its Anti-ulcer activity on Albino Wistar Rat. Research Journal of Pharmacy and Technology. 2022; 15(12): 5751-6. doi: 10.52711/0974-360X.2022.00970
23.    Majumdar M, Samanta A, Roy A. Study of wound healing activity of different formulations of Nigella sativa seed extract. Research Journal of Pharmacy and Technology. 2016; 9(12): 2097-105.doi: 10.5958/0974-360X.2016.00427.3
24.    Reddy YV, Reddy PS, Shivalingam MR. Protective effects of testosterone on cisplatin induced impairment of spermatogenesis and steroidogenesis in rats. Research Journal of Pharmacy and Technology. 2010;3(2):535-9.
25.    Benmebrouk L, Kaddour A, Mohammedi L, Achouri A. Chemical detection of certain greenhouse gases by the LIDAR Technique.Asian Journal of Research in Chemistry. 2021; 14(3): 195-2.   doi: 10.52711/0974-4150.2021.00035
26.    Ibrahim MK, Tikamdas R, Kamal M, Nouh RA, Sayed M. Testosterone Undecanoate effects on behavior and Cognitive Functions in male swiss Albino mice exposed to Chronic Social Defeat. Research Journal of Pharmacy and Technology. 2020; 13(12): 6041-9.doi:10.5958/0974-360X.2020.01053.7
27.    Revathi R, Julius A. A biological effect of sex hormone binding globulin and testosterone in polycystic ovary syndrome (PCOS) obese women. Research Journal of Pharmacy and Technology. 2017; 10(7): 2143-5.doi: 10.5958/0974-360X.2017.00377.8


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available