Author(s): Sunil Chowdary K, Ayyakannu Arumugam Napoleon

Email(s): ,

DOI: 10.52711/0974-360X.2024.00304   

Address: Sunil Chowdary K, Ayyakannu Arumugam Napoleon
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore - 632014, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024

Generally maximum times applied route for administration of drugs is oral only. The drugs that are given orally but are having smaller half-life and great dosing rate of recurrence are very promising methodology is oral extended release drug delivery system. In this system, frequency of dosing diminishes or moderates for assured drugs through slow release of drug over an extended time period. Extended release drug delivery system can affect by different physicochemical and biological properties. The present review contains brief–up on innumerable oral extended release formulation methodologies.

Cite this article:
Sunil Chowdary K, Ayyakannu Arumugam Napoleon. Review of Extended Drug Delivery Oral Formulations. Research Journal of Pharmacy and Technology.2024; 17(4):1916-4. doi: 10.52711/0974-360X.2024.00304

Sunil Chowdary K, Ayyakannu Arumugam Napoleon. Review of Extended Drug Delivery Oral Formulations. Research Journal of Pharmacy and Technology.2024; 17(4):1916-4. doi: 10.52711/0974-360X.2024.00304   Available on:

1.    Kumar Sunil, Kumar Anil, Gupta Vaibhav, Malodia Kuldeep, Rakha Pankaj. Oral Extended Release Drug Delivery System: A Promising Approach. Asian J. Pharm. Tech. 2012;  2(2): 38-43.
2.    Shivakumar H G, Gowda D V, Kumar T M P. Floating controlled drug delivery systems for prolonged gastric residence: a review. Ind. J. Pharm. 2004; 38(45): Pp. 172-178.
3.    Ashok V. Bhosale, Rahul V. Takawale, sanjay D. Sawamy. Oral novel drug delivery system, The Eastern Pharmacist. 2000: 41- 43.
4.    Nchols G. Popovich, Howard C. Ansel, Loyd V. Allen. Pharmaceutical Dosage Forms and Drug Delivery System. 2005: 8th Edition, Pp. 260-275.
5.    Adeyeye Chistianah Moji, Brittain G. Harry. Introduction and overview to the preformulation development of solid dosage forms. Chapter-1, “Preformulation in solid dosage form development”, Inform a Healthcare, Vol.-178, Pp. 1.
6.    El-halim S M A, Amin M M, Gazayerly O N E, Gawad N A A E. Salbutamol sulphate controlled release hydrophllic matrix tablets. RGUHS Journal of Pharmaceutical Sciences. 2011; 1(3): 194-200.
7.    Khan M G, Controlled release oral dosage forms: Some recent advances in matrix type drug delivery systems, The Sciences. 2001; 1(5): 350-354.  
8.    Ghosh A, Gupta K S. Formulation, development and in-vitro evaluation of sustained release matrix tablets of salbutamol sulphate, JPRHC. 2003; 2(3): 222-27. Available on:
9.    Food and Drug Administration (FDA), Center for Drug Evaluation and Research (CDER). Guidance for Industry, SUPAC-MR: Modified Release Solid Oral Dosage Forms. 1997; Available on:
10.    de Haan, P. and Lerk, C.F. Oral controlled release dosage forms. A review. Pharmacy World and Science. 1984; 6(2): 57-67. doi: 10.1007/BF01953956.
11.    Hoffman, A. Pharmacodynamic aspects of sustained release preparations. Advanced Drug Delivery Reviews. 1998; 33(3): 185-199. doi: 10.1016/s0169-409x(98)00027-1.
12.    Krämer, J. and Blume, H, “Biopharmaceutical aspects of multiparticulates- Multiparticulate oral drug delivery”. New York: Informa Health Care; 1994: Pp. 307-332.
13.    Das, N.G. and Das, S.K. Controlled-Release of Oral Dosage Forms. Formulation, Fill and Finish.  2003; 10-16. Available on: pdf/article-59302. pdf.
14.    Ehab Ahmed MH. Ph.D. Thesis: Application and evaluation of extended release technology to loop diuretics. Doctoral dissertation, University of Cincinnati, 2002; 78-82. Available on
15.    Madhusudhan P and Nazeer S: Extended release formulation. International Journal of Pharmacy and Technology. 2010; 2: 625-684.
16.    Pogula M, Nazeer S. Extended release formulation, International Journal of Pharmacy and Technology. 2010; 2(4):. 625-84.
17.    Jain N K. Controlled and novel drug delivery system, In progress in controlled and novel drug delivery system. C B S Publishers and Distributors, New Delhi, 2004; 1: 419-35.
18.    Dandagi P M, Masthiholimath V S, Patil M B, Manvi F V, Gadad A P, Sharma R. Development and evaluation of theophylline and salbutamol sulphate sustained release matrix tablets.  Indian Journal of Pharm. Sci. 2005; 76(5): 598-602.  
19.    Nokhodchi, Ali, Raja Shaista, Patel Pryia and Asare-Addo Kofi.The Role of Oral Controlled Release Matrix Tablets in Drug Delivery Systems. Bioimpacts. 2012; 2(4): 175–187. doi: 10.5681/bi.2012.027.
20.    Kanagagiri D, Omprakash H, Kishorekumar M, Vishwanadham Y. Formulation and evaluation of Pantaprazole delayed release tablets using Eudragit l30D55. Research J. Pharm and Tech. 2017; 10(2): 421-425. doi: 10.5958/0974-360X.2017.00084.1.
21.    Tripathi KD. Antihypertensive Drugs In: Essentials of Medical Pharmacology, 5th edition, Jaypee Brothers Medical Publishers, 2003; Pp. 115-120.  
22.    Rang HP, Dale MM. The Vascular System. In: Pharmacology, Churchill Living Stone, International Journal of Clinical Pharmacology. 2003; 1: 298-302.
23.    Harsh M., The Kidney and Lower Urinary Tract. In: Textbook of Pathology, 6th edition Jaypee Brothers Medical Publishers. 2000; 2: 649-654.  
24.    Lordi G. Nicholas. Sustained release dosage form, Leon Lechman, Liberman, Kanig, The Theory and Practice of Industrial Pharmacy, 1987; (3): 430-45614.    
25.    Patel Harnish, Panchal R Dhrupesh, Patel Upendra, et al. Matrix Type Drug Delivery System: A Review. Journal of Pharmaceutical Science an Bioscientific Research. 2011; 1(3): 143-151.  
26.    Kumar, Satinder, Shashi Kant, Prashar Bharat. Sustained Release drug delivery system: A Review. International Journal of Institutional Pharmacy and Life Sciences. 2012; 2(3): 356-376.
27.    Dusana Abhijit Ratilal, Gaikwad Priti D, Bankar Vidyadhar H, et al. A review on: Sustained released technology. International Journal of Research in Ayurveda and Pharmacy. 2011; 2(6): 1701-1708.
28.    Kamboj S, Gupta GD. Matrix Tablets: An important tool for oral controlled release dosage forms. 2009; 7:1-9.
29.    Vyas SP, Khar RK. Controlled Drug Delivery: Concepts and Advances. 1st ed. Vallabh Prakashan; 2002; 156-189.
30.    Bechgaard H, Nielson GH. Controlled release multiple units and single unit dosage. Drug Dev. and Ind. Pharm. 1978; 4: 53-67.  
31.    Herbig SM, Cardinal JR, Korsmeyer RW, Smith KL. Asymmetric membrane tablet coatings for osmotic drug delivery. J. Control. Release. 1995; 35: 127-136.
32.    Gupta S, Singh RP, Sharma R, Kalyanwat R, Lokwani P. Osmotic pumps: A review. Int. Journal of Comprehensive Pharmacy. 2011; 6: 1-8. doi: 10.5402/2012/528079.
33.    Pradnya M. Khandagale, Bhushan Bhairav, R.B. Saudagar. Osmotically Controlled Drug Delivery System-A Novel Approach. Asian J. Res. Pharm. Sci. 2017; 7(2): 68-76. doi: 10.5958/2231-5659.2017.00010.8
34.    Lapidus H, Lordi NG. Studies on controlled release formulations. Journal of Pharmaceutical sciences. 1968; 57: 1292-1301.
35.    Kamboj S, Gupta GD. Matrix Tablets: An important tool for oral controlled release dosage forms. 2009; 7:1-9
36.    Pundir S., Badola A., Sharma D. Sustained release matrix technology and recent advance in matrix drug delivery system: a review. International Journal of Drug Research and Technology. 2013; 3(1): 12-20.  
37.    Hadi Md. A., Lokeswara V.B., Pal N., and Rao S. A. Formulation and evaluation of sustained release matrix tablets of montelukast. International Journal of Pharmacy, 2012; 2(3): 574-582.
38.    Vyas S.P, Khar R.K. Controlled Drug Delivery Concept and Advances, 2012; 2nd Edn Delhi: 1-53.
39.    Brahmankar H, Jaiswal S. Biopharmaceutics and Pharmacokinetics A Treatise. Vallabh Prakashan. 2000: 337: 348–357.
40.    Gothi GD, Parinh BN, Patel TD, Prajapati ST, Patel DM, Patel CN, Journal of Global Pharma Technology, 2010; 2(2): 69-74.
41.    Rekha Kallam, Padma Sree K, Srinivas Arutla and M.A Bari. Formulation and Evaluation of Extended Release Matrix Formulation of Metoprolol Succinate.  Research J. Pharm. and Tech January. 2011; 4(1): 160-164.  
42.    Sayed I, Abdel-Rahman, Gamal MM, El-Badry M. Preparation and comparative evaluation of sustained release metoclopramide hydrochloride matrix tablets, Saudi Pharmaceutical Journal. 2009; 17(2): 283-288. doi: 10.1016/j.jsps.2009.10.004.
43.    P. Shanmugapriya1, K. Manivel, R. Selvamuthukumar, R. Sanilkumar. Formulation Development and In-vitro Evaluation of Potassium Chloride Extended-Release tablets”, Research J. Pharm. and Tech. 2020; 13(10): 4697-4701. doi: 10.5958/0974-360X.2020.00826.4.
44.    Chandran S, Laila FA, Mantha N. Design and evaluation of Ethyl Cellulose Based Matrix Tablets of Ibuprofen with pH Modulated Release Kinetics”, Indian Journal of Pharmaceutical Sciences. 2008; 5(70): 596-602. doi: 10.4103/0250-474X.45397.
45.    Jyotir Patel. Development and Optimization of Extended-Release Venlafaxine HCl Matrix Tablet. Asian J. Pharm. Tech. 2013; 3(2): 76-80.  
46.    Basak SC, Reddy JBM, and Lucas Mani KP. Formulation and release behaviour of sustained release ambroxol hydrochloride HPMC matrix tablet. Indian Journal of Pharmaceutical Sciences. 2006; 5(68): 594-598.
47.    Varshosaz J, Tavakoli N and Kheirolahi. Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride American Association of Pharmaceutical Scientists. 2006; 7(1): E168-174. doi: 10.1208/pt070124.
48.    Gren T, Bjerre C, Camber O, Ragnarsson G. In vitro drug release from porous cellulose matrices. Int J Pharm 1996; 141(1-2): 53-62.
49.    Syed IA, Mangamoori LN, Rao YM. Formulation and characterization of matrix and triple-layer matrix tablets for controlled delivery of metoprolol tartrate.  Int J Pharm Sci Drug Res.  2011; 3(1): 23-8.  .
50.    Sathiyaraj S, Devi RD, Hari VBN. Lornoxicam gastro retentive floating matrix tablets: Design and in vitro evaluation. J Adv Pharm Technol Res. 2011; 2(3): 156-62.
51.    Gambhire MN, Ambade KW, Kurmi SD, Kadam VJ, Jadhav KR. Development and in vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride. AAPS Pharm Sci Tech. 2007; 8(3): 1-9. DOI: 10.1208/pt0803073.
52.    Arafat M. Simple HPLC validated method for the determination of diltiazem hydrochloride in human plasma. Int J Pharm Pharm Sci. 2014; 6(9): 213-6.  
53.    Archana D. Kajale, Chandrashekhar K. Gadewar, Prafful P. Kothari. Formulation and Evaluation of Floating Microencapsules of Diltiazem Hydrochloride by Hot Melt Granulation Method. Research J. Pharm. and Tech. 2020; 13(1): 227-232. DOI: 10.5958/0974-360X.2020.00046.3.   
54.    P Kumar, R Tiwari, B Chaurasia, RR Sahu, FM Tripathi, Anjana Bhardhwaj. Multi Particulate Extended Release Formulation for Propranolol Hydrochloride.  Research J. Pharm. and Tech. 2010; 3(3): 835-839.  
55.    Balamuralidhara V, Pramod kumar TM, Srujana N, Venkatesh MP, Gupta NV, Krishna KL. pH sensitive drug delivery systems: a review. Am J Drug Discovery Dev. 2011; 1(1): 24-48. DOI: 10.3923/ajdd.2011.24.48.
56.    Sagar Kadam, Pradip Yadav, Dhananjay Landge. Formulation and Evaluation of Colon Targeted Enteric Coated Tablets of Loperamide.  Research J. Pharm. and Tech. 2020; 13(3): 1447-1452. DOI: 10.5958/0974-360X.2020.00264.4.
57.    Arora G, Malik K, Singh I, Arora S, Rana V. Formulation and evaluation of controlled release matrix mucoadhesive tablets of domperidone using saliva plebeian gum. J Adv Pharm Technol Res. 2011; 2(3): 163-169. doi: 10.4103/2231-4040.85534.
58.    S. Nandhakumar, G. Sugreevudu, N. Harikrishnan. Formulation design and Evaluation of Extended-Release Tablets of Oxybutynin for Effective Management of Overactive Bladder Syndrome.  Research J. Pharma. and Tech. 2021; 14(12): 6558-6564. DOI: 10.52711/0974-360X.2021.01135.
59.    Nisargi Shah, Chintan Oza, Shital Trivedi, Nihar Shah, Shreeraj S. Review on Sustained Release Matrix Tablets: An Approach to Prolong the Release of Drug. JPBSR. 2015; 5(3): 315-321.
60.    Lachman Leon, Lieberman Herbert A. Pharmaceutical Dosage Forms: Tablets. In: The Theory and Practice of Industrial Pharmacy. Lea and Febiger, U.S.A, 1991; 3rd edition: 293-345. Available on:
61.    Paresh R. Mahaparale, Bhanudas S. Kuchekar. Sustained Release Wax Matrix Tablet of Metoprolol Succinate. Research J. Pharm. and Tech. 2012; 5(11): 1408-1412.
62.    Misal R, Atish W, Aqueel S. Matrix tablets: A promising Technique for controlled drug delivery. Indo Am. J. Pharm. Res. 2013; 3(5): 3791–805.
63.    Gondkar S.B, Shewale Lankesh P, Saudagar R.B. An Overview on Sustain Release Matrix Drug Delivery. Research J. Pharm. Dosage form. and Tech. 2016; 8(2): 154-160. DOI: 10.5958/2231-5659.2020.00031.4.
64.    Chaudhari AR, Gujarathi NA, Rane BR, Pawar SP, Bakliwal SP. Novel Sustained Release Drug Delivery System: A Review. A J. Pharm. Res. 1999; 8(1):80–97.
65.    Testsuo H, Hideyoshi K, Minoru O, Ichiro K, Yasuo I et al. In vitro and in vivo sustained-release characteristics of theophylline matrix tablets and novel cluster tablets Int. J. Pharm. Sci. 2007; 341(1-2): 105–13. DOI: 10.1016/j.ijpharm.2007.03.048.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available