Author(s):
Nujhat Nabilah, Darío Salguero García, Suresh Babu Kondaveeti, H.S.Batra, Patrik Viktor, Mohammad Chand Jamali, Calvin R. Wei, Jamilur Rahman Bhuiyan, Mustafa Mudhafar, Othman Mahjoob Khalaf, Nikolaos Syrmos, Shpona Roy, Atakhonov Murod Matyakubovich, Sadia Afrin, Md. Rezwan Ahemd Mahedi
Email(s):
rezwanmahed747@gmail.com
DOI:
10.52711/0974-360X.2024.00302
Address:
Nujhat Nabilah1, Darío Salguero García2, Suresh Babu Kondaveeti3, H.S.Batra4, Patrik Viktor5, Mohammad Chand Jamali6, Calvin R. Wei7, Jamilur Rahman Bhuiyan8, Mustafa Mudhafar9, Othman Mahjoob Khalaf10, Nikolaos Syrmos11, Shpona Roy12, Atakhonov Murod Matyakubovich13, Sadia Afrin14, Md. Rezwan Ahemd Mahedi14*
1North South University, Dhaka, Bangladesh.
2Associate Professor, Department of Developmental and Educational Psychology, University of Almería, Almería (Spain).
3Professor, Dept of Biochemistry, Symbiosis Medical College for Women, Symbiosis International (Deemed University), Pune, India.
4Professor and Head, Dept of Biochemistry, Symbiosis Medical College for Women, Symbiosis International (Deemed University), Pune, India.
5Budapest Óbuda University Karoly Keleti faculty, Hungary.
6Assistant Professor, Faculty of Medical & Health Sciences, Liwa College, Al Ain, Abu Dhabi, United Arab Emirates .
7Department of Research and Development, Shing Huei Group, Taipei, Taiw
Published In:
Volume - 17,
Issue - 4,
Year - 2024
ABSTRACT:
The genesis of chronic skin illnesses is intricately intertwined with genetics, the environment, psychological and the immune system. However, recent studies have shown that mental health issues can exacerbate and control the severity of chronic skin disorders. Focusing on illnesses including psoriasis, atopic dermatitis, and urticaria, this article seeks to evaluate and discuss the current literature on the interplay of psychological aspects in chronic skin diseases. Here, we investigate the two-way connection between emotional discomfort (such as stress, worry, or depression) and the physiology of various skin conditions. Furthermore, we address possible mechanisms underlying the link between mental health and skin diseases, which will help the physicians to select the medicines and treatment approach.
Cite this article:
Nujhat Nabilah, Darío Salguero García, Suresh Babu Kondaveeti, H.S.Batra, Patrik Viktor, Mohammad Chand Jamali, Calvin R. Wei, Jamilur Rahman Bhuiyan, Mustafa Mudhafar, Othman Mahjoob Khalaf, Nikolaos Syrmos, Shpona Roy, Atakhonov Murod Matyakubovich, Sadia Afrin, Md. Rezwan Ahemd Mahedi. Examining the Interplay of Psychological Factors in Chronic Skin Disease: A Review on Depression, Anxiety, and Stress. Research Journal of Pharmacy and Technology.2024; 17(4):Research Journal of Pharmacy and Technology.2024; 17(4):1902-8. doi: 10.52711/0974-360X.2024.00302
Cite(Electronic):
Nujhat Nabilah, Darío Salguero García, Suresh Babu Kondaveeti, H.S.Batra, Patrik Viktor, Mohammad Chand Jamali, Calvin R. Wei, Jamilur Rahman Bhuiyan, Mustafa Mudhafar, Othman Mahjoob Khalaf, Nikolaos Syrmos, Shpona Roy, Atakhonov Murod Matyakubovich, Sadia Afrin, Md. Rezwan Ahemd Mahedi. Examining the Interplay of Psychological Factors in Chronic Skin Disease: A Review on Depression, Anxiety, and Stress. Research Journal of Pharmacy and Technology.2024; 17(4):Research Journal of Pharmacy and Technology.2024; 17(4):1902-8. doi: 10.52711/0974-360X.2024.00302 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-76
REFERENCE:
1. Attama C, Uwakwe R, Onyeama G, Igwe M. Psychiatric morbidity among subjects with leprosy and albinism in south east Nigeria: a comparative study. Annals of Medical and Health Sciences Research. 2015;5(3):197–204. https://doi.org/10.4103/2141-9248.157503
2. Klaus W Wolff Lags, Stephen 1.Katz, Barbara A.Gil Chrest, Amy S.Paller, David J.Leffel. Fitzpatrick’s Dermatology in General Medicine. Seventh Edition ed. NEW YORK: The McGraw-Hill Companies; 2008.
3. Zewdu Bezie BD, Dereje Ayele, Desta Workeneh, Muluneh Haile, Gebru Mulugeta, Getachew Belay, et al. Common Skin Diseases. Jimma University In collaboration with the Ethiopia Public Health Training Initiative, The Carter Center, the Ethiopia Ministry of Health, and the Ethiopia Ministry of Education, 2005.
4. Farzanfar D, Dowlati Y, French LE, Lowes MA, Alavi A. Inflammation: a contributor to depressive comorbidity in inflammatory skin disease. Skin Pharmacology and Physiology. 2018;31:246–51. https://doi.org/10.1159/000490002
5. Maan MA, Naureen S, Saddiqua A. Anxiety, depression and self-esteem among chronic skin patients. Annals of Punjab Medical College (APMC). 2010;4(2):159–65.
6. Kimball AB, Linder MD. Dermatological diseases and cumulative life course impairment: Karger Medical and Scientific Publishers; 2013.
7. Sharma S, Bassi R, Singh A. A comparative study of depression and anxiety in psoriasis and other chronic skin diseases. Journal of Pakistan Association of Dermatology. 2016;21(4):235–40.
8. Alharbi MA. Identifying Patients at Higher Risk of Depression Among Patients with Vitiligo at Outpatient Setting. Materia Socio-medica. 2020; 32(2): 108. https://doi.org/10.5455/msm.2020.32.108-111
9. van Dorst MM, van Netten WJ, Waltz MM, Pandey BD, Choudhary R, van Brakel WH. Depression and mental wellbeing in people affected by leprosy in southern Nepal. Global Health Action. 2020;13(1):1815275. https://doi.org/10.1080/16549716.2020.1815275
10. Layegh P, Arshadi HR, Shahriari S, Nahidi Y. A comparative study on the prevalence of depression and suicidal ideation in dermatology patients suffering from Psoriasis, Acne, Alopecia areata and Vitiligo. 2010.
11. Molla GL, Sebhat HM, Hussen ZN, Mekonen AB, Mersha WF, Yimer TM. Depression among Ethiopian adults: cross-sectional study. Psychiatry journal. 2016;2016. https://doi.org/10.1155/2016/1468120
12. Bharati DR, Kumari S, Kumar S, Jaykar KC, Singh KK, Pal R. Prevalence and Correlates of Unrecognised Depression Associated with Common Skin Morbidities among Attendees in a Teaching Hospital Dermatology Outpatient’s Department.
13. Sorour F, Abdelmoaty A, Bahary MH, El Birqdar B. Psychiatric disorders associated with some chronic dermatologic diseases among a group of Egyptian dermatology outpatient clinic attendants. Journal of the Egyptian Women’s Dermatologic Society. 2017;14(1):31–6.
14. Dalgard FJ, Gieler U, Tomas-Aragones L, Lien L, Poot F, Jemec GB, et al. The psychological burden of skin diseases: a cross-sectional multicenter study among dermatological out-patients in 13 European countries. Journal of Investigative Dermatology. 2015; 135(4): 984–91. https://doi.org/10.1038/jid.2014.530
15. Bell KA, Balogh EA, Feldman SR. An update on the impact of depression on the treatment of psoriasis. Expert Opinion on Pharmacotherapy. 2020:1–9. https://doi.org/10.1080/14656566.2020.1849141
16. El-Moselhy EA HS, Mohammed AE, Abd-Alrhman TM, Alnabawy AA, Mosalam A. Psychosocial impact and quality of life among adult Egyptian patients with psoriatic arthritis. The Egyptian Journal of Hospital Medicine. 2017; 66(1):237–47.
17. Gascón MRP, Ribeiro CM, dA Bueno LM, Benute GRG, d Lucia MCS, Rivitti EA, et al. Prevalence of depression and anxiety disorders in hospitalized patients at the dermatology clinical ward of a university hospital. Anais brasileiros de dermatologia. 2012;87(3):403–7. https://doi.org/10.1590/s0365-05962012000300008
18. Yosipovitch G, Tang M, Dawn AG, Chen M, Goh CL, Huak Y, et al. Study of psychological stress, sebum production and acne vulgaris in adolescents. Acta Dermato-Venereologica. 2007;87(2):135–9. https://doi.org/10.2340/00015555-0231
19. Nguyen CM, Beroukhim K, Danesh MJ, Babikian A, Koo J. The psychosocial impact of acne, vitiligo, and psoriasis: a review. Clinical, cosmetic and investigational dermatology. 2016;9:383. https://doi.org/10.2147/CCID.S76088
20. Dai Y-X, Tai Y-H, Chang Y-T, Chen T-J, Chen M-H. Association between major depressive disorder and subsequent autoimmune skin diseases: A nationwide population-based cohort study. Journal of Affective Disorders. 2020. https://doi.org/10.1016/j.jad.2020.05.070
21. Fried RG, Gupta MA, Gupta AK. Depression and skin disease. Dermatologic clinics. 2005;23(4):657–64. https://doi.org/10.1016/j.det.2005.05.014
22. Evers A, Duller P, Van De Kerkhof P, Van der Valk P, De Jong E, Gerritsen M, et al. The Impact of Chronic Skin Disease on Daily Life (ISDL): a generic and dermatology‐specific health instrument. British Journal of Dermatology. 2008;158(1):101–8. https://doi.org/10.1111/j.1365-2133.2007.08296.x
23. Kamiya K., Kishimoto M,; Sugai, J, Komine M., Ohtsuki M. Risk Factors for the Development of Psoriasis. IJMS 2019, 20, 4347.
24. Yang H., Zheng J. Influence of Stress on the Development of Psoriasis. Clinical and Experimental Dermatology. 2020, 45, 284–288.
25. Hunter H.J.A., Griffiths C.E.M., Kleyn C.E. Does Psychosocial Stress Play a Role in the Exacerbation of Psoriasis? British Journal of Dermatology. 2013, 169, 965–974.
26. Connor CJ., Liu V., Fiedorowicz JG. Exploring the Physiological Link between Psoriasis and Mood Disorders. Dermatology Research and Practice. 2015, 2015, 1–11.
27. Jain S. Pathogenesis of chronic urticaria: An overview. Dermatol. Res. Pract. 2014, 2014, 674709.
28. Konstantinou GN., Riedl MA.,Valent P., Podder I., Maurer M. Urticaria and angioedema: Understanding complex pathomechanisms to facilitate patient communication, disease management, and future treatment. Journal of Allergy and Clinical Immunology. 2023, 11, 94–106.
29. Church, MK., Kolkhir P, Metz M, Maurer M. The role and relevance of mast cells in urticaria. Immunological Reviews. 2018, 282, 232–247.
30. Tomaszewska K, Słodka A, Tarkowski B, Zalewska-Janowska A. Neuro–Immuno–Psychological Aspects of Chronic Urticaria. Journal of Clinical Medicine. 2023; 12(9):3134. https://doi.org/10.3390/jcm12093134
31. Varghese R, Rajappa M, Chandrashekar L, et al. Association among stress, hypocortisolism, systemic inflammation, and disease severity in chronic urticaria. Annals of Allergy, Asthma and Immunology. 2016;116(4):344-348.e1. https://doi.org/10.1016/j.anai.2016.01.016
32. Zabolinejad N, Molkara S, Bakhshodeh B, Ghaffari-Nazari H, Khoshkhui M. The expression of serotonin transporter protein in the skin of patients with chronic spontaneous urticaria and its relation with depression and anxiety. Archives of Dermatological Research. 2019;311(10):825-831. https://doi.org/10.1007/s00403-019-01969-y
33. Lin T-K, Zhong L, Santiago JL. Association between Stress and the HPA Axis in the Atopic Dermatitis. International Journal of Molecular Sciences. 2017; 18(10):2131. https://doi.org/10.3390/ijms18102131
34. Rolfsjord LB, Skjerven HO, Bakkeheim E, Berents TL, Carlsen KH, Carlsen KCL. Quality of life, salivary cortisol and atopic diseases in young children. PLoS One. 2019;14(8):e0214040. Published 2019 Aug 30. https://doi.org/10.1371/journal.pone.0214040
35. Paramita DA, Nasution K, Lubis NZ. Relationship of Substance P with the Degree of Atopic Dermatitis Severity. Clinical, Cosmetic and Investigational Dermatology. 2021;14:551-555. Published 2021 May 25. https://doi.org/10.2147/CCID.S306557
36. Smith B, Collier MR, Devjani S, Han G, Wu JJ. Association between atopic dermatitis and thyroid disease among U.S. adults in the 2001-2006 National Health and Nutrition Examination Survey. Journal of the American Academy of Dermatology. 2023;88(4):889-891. https://doi.org/10.1016/j.jaad.2022.10.017
37. Gisondi P, Geat D, Bellinato F, et al. Psychological Stress and Salivary Cortisol Levels in Patients with Plaque Psoriasis. Journal of Personalized Medicine. 2021;11(11):106. https://doi.org/10.3390/jpm11111069
38. Remröd C, Lonne-Rahm S, Nordlind K. Study of substance P and its receptor neurokinin-1 in psoriasis and their relation to chronic stress and pruritus. Arch Dermatol Res. 2007; 299(2): 85-91. https://doi.org/10.1007/s00403-007-0745-x
39. Connor CJ, Liu V, Fiedorowicz JG. Exploring the Physiological Link between Psoriasis and Mood Disorders. Dermatology Research and Practice. 2015, 2015, 1–11.
40. Veena Prabavathy J, Sangeetha R. An Association between Work Stress and Serum Cortisol with the development of Type 2 Diabetes Mellitus among Industrial Workers. Research J. Pharm. and Tech. 2020; 13(1): 27-32. https://doi.org/10.5958/0974-360X.2020.00005.0.
41. Lin TK, Zhong, L, Santiago, J. Association between Stress and the HPA Axis in the Atopic Dermatitis. IJMS 2017, 18, 2131.
42. Torales J, Echeverría C, Barrios I, García O, O’Higgins M, Castaldelli-Maia, JM, Ventriglio A, Jafferany M. Psychodermatological Mechanisms of Psoriasis. Dermatologic Therapy. 2020, 33, e13827.
43. Slominski, A. On the Role of the Corticotropin-Releasing Hormone Signalling System in the Aetiology of Inflammatory Skin Disorders. British Journal of Dermatology. 2009; 160: 229–232.
44. Nandakumar, Gheena S. Cortisol in Saliva of Uncontrolled Diabetes Patients and Adrenal Stress Index. Research Journal of Pharmacy and Technology. 2016; 9(10): 1786-1788. https://doi.org/10.5958/0974-360X.2016.00361.9.
45. Kannan S., Heller MM, Lee ES, Koo JY. The Role of Tumor Necrosis Factor-Alpha and Other Cytokines in Depression: What Dermatologists Should Know. Journal of Dermatological Treatment. 2013; 24: 148–152.
46. Theoharides TC. The Mast Cell: A Neuroimmunoendocrine Master Player. International Journal of Tissue Reactions. 1996, 18, 1–21.
47. Theoharides TC. Neuroendocrinology of Mast Cells: Challenges and Controversies. Experimental Dermatology. 2017; 26: 751–759.
48. Skobowiat C, Slominski AT. UVB Activates Hypothalamic–Pituitary–Adrenal Axis in C57BL/6 Mice. Journal of Investigative Dermatology. 2015; 135: 1638–1648.
49. Skobowiat C, Postlethwaite, AE., Slominski AT. Skin Exposure to Ultraviolet B Rapidly Activates Systemic Neuroendocrine and Immunosuppressive Responses. Photochemistry and Photobiology. 2017; 93: 1008–1015.
50. DhabharFS, Saul AN, Daugherty C, Holmes TH, Bouley DM, Oberyszyn T.M. Short-Term Stress Enhances Cellular Immunity and Increases Early Resistance to Squamous Cell Carcinoma. Brain, Behavior, and Immunity. 2010, 24, 127–137.
51. Kojima R., Matsuda A., Nomura I., Matsubara O., Nonoyama S., Ohya Y., Saito H., Matsumoto K. Salivary cortisol response to stress in young children with atopic dermatitis. Pediatric Dermatology. 2013; 30: 17–22.
52. Haeck IM., Timmer-de Mik L., Lentjes EG., Buskens E., Hijnen DJ., Guikers C., Bruijnzeel-Koomen CA., de Bruin-Weller MS. Low basal serum cortisol in patients with severe atopic dermatitis: Potent topical corticosteroids wrongfully accused. British Journal of Dermatology. 2007; 156: 979–985.
53. Harbuz MS, Stephanou A., Knight RA. Chover-Gonzalez AJ., Lightman SL. Action of interleukin-2 and interleukin-4 on CRF mRNA in the hypothalamus and POMC mRNA in the anterior pituitary. Brain, Behavior, and Immunity. 1992; 6: 214–222.
54. Watanabe T., Fujioka T., Hashimoto M., Nakamura S. Stress and brain angiotensin II receptors. Critical Reviews in Neurobiology. 1998; 12: 305–317.
55. DiMicco JA., Sarkar S., Zaretskaia MV., Zaretsky DV. Stress-induced cardiac stimulation and fever: Common hypothalamic origins and brainstem mechanisms. Autonomic Neuroscience. 2006; 126–127: 106–119.
56. Smith SM., Vale WW. The role of the hypothalamic–pituitary–adrenal axis in neuroendocrine responses to stress. Dialogues in Clinical Neuroscience. 2006; 8: 383–395.
57. Stephens MA., Wand G. Stress and the HPA axis: Role of glucocorticoids in alcohol dependence. Alcohol Research. 2012; 34: 468–483.
58. Fukada, M.; Kaidoh, T.; Ito, A.; Yano, T.; Hayashibara, C.; Watanabe, T. “Green odor” inhalation reduces the skin-barrier disruption induced by chronic restraint stress in rats: Physiological and histological examinations. Chem. Senses 2007; 32: 633–639.
59. Aioi A., Okuda M., Matsui M., Tonogaito H., Hamada K. Effect of high population density environment on skin barrier function in mice. Journal of Dermatological Science. 2001; 25: 189–197.
60. Choi EH., Crumrine D., Brown BE., Mauro T., Elias PM., Feingold KR. Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity. Journal of Investigative Dermatology. 2005; 124: 587–595.
61. Choi EH., Demerjian M., Crumrine D., Brown BE., Mauro T., Elias PM., Feingold KR. Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function. American Journal of Physiology- Regulatory Integrative and Comparative Physiology. 2006; 291: 1657–1662.
62. Lin, T.K.; Man, M.Q.; Santiago, J.L.; Scharschmidt, T.C.; Hupe, M.; Martin-Ezquerra, G.; Youm, J.K.; Zhai, Y.; Trullas, C.; Feingold, K.R.; et al. Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid mediated. Journal of Investigative Dermatology. 2014; 134: 2890–2897.
63. Buske-Kirschbaum A., Gierens A., Hollig H., Hellhammer DH. Stress-induced immunomodulation is altered in patients with atopic dermatitis. Journal of Neuroimmunology. 2002; 129: 161–167.
64. Buske-Kirschbaum, A., Geiben, A., Hollig H., Morschhauser E.,Hellhammer, D. Altered responsiveness of the hypothalamus-pituitary-adrenal axis and the sympathetic adrenomedullary system to stress in patients with atopic dermatitis. Journal of Clinical Endocrinology and Metabolism. 2002; 87: 4245–4251.
65. Park G., Lee SH., Oh, D.S. Kim Y.U. Melatonin inhibits neuronal dysfunction-associated with neuroinflammation by atopic psychological stress in NC/Nga atopic-like mouse models. Journal of Pineal Research. 2017; 63.
66. Chrousos GP. Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture. Ann. N. Y. Acad. Sci. 1998; 851: 311–335.
67. Tsigos C., Chrousos GP. Hypothalamic–pituitary–adrenal axis, neuroendocrine factors and stress. Journal of Psychosomatic Research. 2002; 53: 865–871.
68. Kellner, M.; Yassouridis, A.; Manz, B.; Steiger, A.; Holsboer, F.; Wiedemann, K. Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers—A potential link to low-melatonin syndrome in depression? Neuroendocrinology. 1997; 65: 284–290.
69. Slominski, Zmijewski, Semak, Kim, Janjetovic, Slominski, Zmijewski, JW. Melatonin, mitochondria, and the skin. Cellular and Molecular Life Sciences. 2017; 12: 1–13.
70. Robinson, Jarrett, Broadbent E. The effects of relaxation before or after skin damage on skin barrier recovery: A preliminary study. Psychosomatic Medicine. 2015; 77: 844–852.
71. Mikhail Kasatkin, Lyudmila Smirnova, Dmitrii Babaskin. Therapeutic effects of Probiotic Ointment for Atopic Dermatitis. Research Journal of Pharmacy and Technology. 2021; 14(11): 6041-8. doi: 10.52711/0974-360X.2021.01050
72. Divya, Inderbir Singh, Upendra Nagaich. Characterisation and Evaluation of prepared Fluconazole Nanogel for Treating Seborrheic Dermatitis. Research Journal of Pharmacy and Technology 2023; 16(6): 2880-4. https://doi.org/10.52711/0974-360X.2023.00474
73. Deepti Dwivedi, Shubham Pandey, Shafaque Asif, Vineet Awasthi, Gurjeet Kaur, Nimisha. Investigating the potential of Quercetin enthused nano lipoidal system for the management of dermatitis. Research Journal of Pharmacy and Technology. 2021; 14(12): 6516-6. https://doi.org/10.52711/0974-360X.2021.01127
74. Suralkar Anupama A., Jadhav Asha S., Vaidya Gayatri S., Sharma Ashish, Meghraj Chaudary, Vivek Bhora. Antiallergic, Antianaphylactic and Mast Cell Stabilizing, Activity of Embeliaribesbrum. Research Journal of Pharmacy and Technology. 2013; 6(11): 1190-1194.
75. Aberg KM., Radek KA., Choi EH, Kim DK, Demerjian M., Hupe M.,Kerbleski, J., Gallo RL., Ganz T., Mauro, T. Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J. Clin. Investig. 2007; 117: 3339–3349.
76. Sadia Afrin, Nujhat Nabilah, Rima Akter Rimi, Samee U Sayed, Ahasan Habib, Shahminajada, Mustafa Mudhafar, Nikolaos Syrmos, Md Rezwan Ahmed Mahedi. Finding the Causes of the Concretion Between Asthma and Urticaria: A Narrative Review. J Clin Immunol Microbiol. 2023; 4(1): 1-7. http://dx.doi.org/10.46889/JCIM.2023.4104
77. Tat TS. Higher Levels of Depression and Anxiety in Patients with Chronic Urticaria. Med Sci Monit. 2019; 25: 115-120. doi:10.12659/MSM.912362
78. Sarah Andrea Wilson, Anushree Nagaraj, Lalitha Vaidyanathan. Calocybe indicia extract modifies GABA and Serotonin levels to Alleviate anxiety in experimental adult Zebrafish models. Research Journal of Pharmacy and Technology. 2021; 14(9): 4789-4. https://doi.org/10.52711/0974-360X.2021.00833
79. Ravindra G. Gaikwad, Anilkumar J. Shinde, Ashok A. Hajare. Herbal Treatment for Management of Psoriasis: An Overview. Research Journal of Pharmacy and Technology. 2022; 15(3): 1385-2. doi: 10.52711/0974-360X.2022.00231
80. Sakthi Priyadarsini S, Vani PB, Kumar PR. A Comparative Review on Conventional and Traditional medicine in the Treatment of Psoriasis. Research J. Pharm. and Tech. 2020; 13(11): 5642-5646. https://doi.org/10.5958/0974-360X.2020.00983.X