Author(s): Nina Nurarifah, Siti Fatonah, Herwindo Pudjo Brahmantyo, Shod Abdurrachman Dzulkarnain, Shinta Oktya Wardhani

Email(s): ninanur@ub.ac.id , sitifatonah@ub.ac.id , herwindopudjo.ipd@ub.ac.id , shodzulkarnain@unesa.ac.id , shinta_oktya.fk@ub.ac.id

DOI: 10.52711/0974-360X.2024.00233   

Address: Convalescent Plasma Therapy Significantly improves the Clotting Kinetics of COVID-19 patients Nina Nurarifah1, Siti Fatonah2, Herwindo Pudjo Brahmantyo1, Shod Abdurrachman Dzulkarnain3, Shinta Oktya Wardhani1
1Division of Hematology and Oncology, Department of Internal Medicine of Dr. Saiful Anwar General Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
2Department of Clinical Pathology of Dr. Saiful Anwar General Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
3Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Surabaya, Surabaya, East Java, 60231, Indonesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
Convalescent plasma therapy is approved as an effective therapy for severe or critical cases of COVID-19. However, there is concern regarding the impact of procoagulant factors in convalescent plasma. This study aims to prove the effect of convalescent plasma therapy on the coagulation status, especially the thromboelastography, of COVID-19 patients at Dr. Saiful Anwar Malang Hospital. This study used a survey method with a cross-sectional design between the group given convalescent plasma and the control group. Data taken from medical records. The independent variable is the convalescent plasma, while the dependent variable is the thromboelastography indicator (TEG); namely R time, K time, MA, and LY30. This study also compares the correlation between convalescent plasma therapy and patients’ comorbidities including hypertension, type 2 diabetes mellitus, and renal disease. Among 305 COVID-19 patients involved in this study, only 142 patients have completed medical record data for thromboelastography evaluation. Patient characteristics analysis shows a certain tendency in patients with comorbidities to receive convalescent plasma therapy. Although many indicators of thromboelastography did not have a significant correlation with convalescent plasma therapy, such as its R time and LY30, finally this study shows K time (which represents clotting kinetics) as the most significant indicator affected by convalescent plasma therapy.


Cite this article:
Nina Nurarifah, Siti Fatonah, Herwindo Pudjo Brahmantyo, Shod Abdurrachman Dzulkarnain, Shinta Oktya Wardhani. Convalescent Plasma Therapy Significantly improves the Clotting Kinetics of COVID-19 patients. Research Journal of Pharmacy and Technology.2024; 17(4):1475-0. doi: 10.52711/0974-360X.2024.00233

Cite(Electronic):
Nina Nurarifah, Siti Fatonah, Herwindo Pudjo Brahmantyo, Shod Abdurrachman Dzulkarnain, Shinta Oktya Wardhani. Convalescent Plasma Therapy Significantly improves the Clotting Kinetics of COVID-19 patients. Research Journal of Pharmacy and Technology.2024; 17(4):1475-0. doi: 10.52711/0974-360X.2024.00233   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-7


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