Author(s): Boulaares Islam, Derouiche Samir, Guemari Imane Yousra

Email(s): dersamebio@gmail.com

DOI: 10.52711/0974-360X.2024.00292   

Address: Boulaares Islam1,2, Derouiche Samir1,2, Guemari Imane Yousra1
1Department of Cellular and Molecular Biology, Faculty of the Sciences of Nature and Life, El-Oued University, El-Oued 39000, El Oued, Algeria.
2Laboratory of Biodiversity and application of biotechnology in the agricultural field, Faculty of the Sciences of Nature and Life, University of El Oued, El-Oued 39000, Algeria.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
This investigation was aimed to study the effect of leaves aqueous extract of Ocimum basilicum L. (ObE) for prevention of cardiotoxicity and heart failure induced by doxorubicin in rats. For in-vivo rats study, 15 female albino Wistar rats were divided into 3 groups (n = 5); control group, doxorubicin treated rats group (DOX) and rats co-treated with doxorubicin and aqueous extract of O. basilicum group (DOX + O. basilicum. Various hematological, enzymatic, and oxidative stress markers were estimated. Histopathology of heart tissues was observed. Results of in-vivo rats study show that doxorubicin treated rats induced elevation in doxorubicin level in heart tissue, alteration in hematological parameters and enzymatic activity compared to control group. In addition, doxorubicin treated rats induced oxidative stress and histological alteration in heart cells compared to control rats. Co-treatment of doxorubicin with leaves aqueous extract of O. basilicum were partially reversed all of previous parameters. This study indicated that the anti-inflammatory and antioxidant property of leaves aqueous extract of O. basilicum allowed using them to protect organs from the side effects of doxorubicin or from the destructive effects of various diseases.


Cite this article:
Boulaares Islam, Derouiche Samir, Guemari Imane Yousra. Protective effect of ObE against Doxorubicin-Induced immunosuppression and Cardiotoxicity in Rats. Research Journal of Pharmacy and Technology.2024; 17(4):1839-3. doi: 10.52711/0974-360X.2024.00292

Cite(Electronic):
Boulaares Islam, Derouiche Samir, Guemari Imane Yousra. Protective effect of ObE against Doxorubicin-Induced immunosuppression and Cardiotoxicity in Rats. Research Journal of Pharmacy and Technology.2024; 17(4):1839-3. doi: 10.52711/0974-360X.2024.00292   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-66


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