Author(s): Chandrashekar C. Patil, Katte Shubha, Ashwini. S. G, Santosh Karajgi, S.B. Shirsand

Email(s): drccpatil@gmail.com

DOI: 10.52711/0974-360X.2024.00288   

Address: Chandrashekar C. Patil1*, Katte Shubha1, Ashwini. S. G1, Santosh Karajgi1, S.B. Shirsand2
1B.L.D.E.A’s SSM College of Pharmacy,Vijayapur – 586101.
2HKES’s MTRIPS, Kalaburagi – 585105.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
Drugs with a narrow absorption window in the gastrointestinal tract (GIT) will have poor absorption. For these drugs, gastro retentive drug delivery system offers the advantage in prolonging the gastric emptying time. Losartan potassium is prescribed to treat hypertension. The current study was projected to prepare a Losartan potassium gastro retentive drug delivery system (GRDDS) of floating tablets was planned to enhance the gastric residence time, thus prolong the drug release. Losartan potassium effervescent floating tablets were prepared by utilizing the direct impression method, using polymers such as HPMCk15, xanthan gum, microcrystalline cellulose, and Sodium carbonate, with lubricants such as magnesium stearate and talc. In the present study, sodium bicarbonate was incorporated as a gas generating agent. And combination of sodium bicarbonate and citric acid was found to achieve optimum in vitro buoyancy. Total eight formulations were designed and evaluated for pre-compression parameters known as angle of repose, bulk density, tapped density, Hausner's ratio, compressibility index, and post -compression parameters are uniformity of weight variation, hardness, thickness, friability, floating lag time, and in vitro dissolution investigation and FTIR along with DSC is carried out


Cite this article:
Chandrashekar C. Patil, Katte Shubha, Ashwini. S. G, Santosh Karajgi, S.B. Shirsand. Formulation and Evaluation of Microspheres Containing Mefenamic Acid by Inotropic Gelation Method. Research Journal of Pharmacy and Technology.2024; 17(4):1812-6. doi: 10.52711/0974-360X.2024.00288

Cite(Electronic):
Chandrashekar C. Patil, Katte Shubha, Ashwini. S. G, Santosh Karajgi, S.B. Shirsand. Formulation and Evaluation of Microspheres Containing Mefenamic Acid by Inotropic Gelation Method. Research Journal of Pharmacy and Technology.2024; 17(4):1812-6. doi: 10.52711/0974-360X.2024.00288   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-62


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