Author(s): Alfred-Ugbenbo Deghinmotei, Blazheyevskiy Mykola Yevstahiyovich, Micah Ebena, Moroz Valery Petrovich

Email(s): audeghinmotei@gmail.com

DOI: 10.52711/0974-360X.2024.00287   

Address: Alfred-Ugbenbo Deghinmotei1*, Blazheyevskiy Mykola Yevstahiyovich2, Micah Ebena3, Moroz Valery Petrovich2
1Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Bayelsa Medical University, P.M.B. 178, Bayelsa State, Nigeria.
2Department of Analytical Chemistry and Analytical Toxicology, National university of pharmacy, 61168, Kharkiv, Ukraine.
3Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Bayelsa Medical University, P.M.B. 178, Bayelsa State, Nigeria.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
This work is aimed at studying the kinetics of Cetirizine (CTZ) and Levocetirizine(L-Cet) oxidation by potassium hydrogen peroxomonosulfate (PMS) in the form of Oxone and developing an analytical method for their quantitative determination. The required amount of CTZ and L-Cet was dissolved in double distilled water, pH buffer solution and PMS solution were added. After 1.5min, the solution was acidified. The excess PMS was iodometrically titrated applying visual end-point detection approach. The reaction was studied in aqueous media at 293 K and over pH range 7.0 to 10.0. The second order rate constants, k (L mol-1 min-1) has been calculated from kinetic data. A suitable scheme has been proposed for the oxidation of CTZ and L-Cet with PMS, which shows electrophilic attack of the monoanion of PMS on a nitrogen atom of the analyzed compounds with the formation of the corresponding amine oxides. CTZ and L-Cet were determined by indirect titration with PMS. The recovery of the assayed analytes in tablets ranged from 99.4 to 101.0%. A paired t-test showed that all results obtained for CTZ and L-Cet in model solutions and dosage form of Levocetirizine (5mg) and ?etirizine (10mg) tablets, using the proposed procedure and the official procedure respectively, were in consonance at the 95 % confidence level, (? ¯ -µ) 100/µ < RSD. Techniques have been developed and the possibility of quantitative determination of Levocetirizine and Cetirizine in substance and tablet forms using Oxone as an analytical reagent has been demonstrated.


Cite this article:
Alfred-Ugbenbo Deghinmotei, Blazheyevskiy Mykola Yevstahiyovich, Micah Ebena, Moroz Valery Petrovich. Oxidimetric determination of Cetirizine and Levocetirizine in tablets using Oxone. Research Journal of Pharmacy and Technology. 2024; 17(4):1805-1 doi: 10.52711/0974-360X.2024.00287

Cite(Electronic):
Alfred-Ugbenbo Deghinmotei, Blazheyevskiy Mykola Yevstahiyovich, Micah Ebena, Moroz Valery Petrovich. Oxidimetric determination of Cetirizine and Levocetirizine in tablets using Oxone. Research Journal of Pharmacy and Technology. 2024; 17(4):1805-1 doi: 10.52711/0974-360X.2024.00287   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-61


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