Author(s): Madhurima Ghosh, Miltu Kumar Ghosh, Debabrata Devbhuti, Sandipan Dasgupta, Pritesh Devbhuti

Email(s): ghoshmadhurima92@gmail.com , miltu.ghosh@nshm.com , ddjupt73@gmail.com , sandipan.dasgupta21@gmail.com , priteshdevbhuti@gmail.com

DOI: 10.52711/0974-360X.2024.00285   

Address: Madhurima Ghosh1, Miltu Kumar Ghosh1, Debabrata Devbhuti2, Sandipan Dasgupta3, Pritesh Devbhuti1*
1Department of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata - 700053, India.
2Department of Pharmacy, Jnan Chandra Ghosh Polytechnic, Kolkata - 700023, India.
3Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Haringhata, Nadia, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
Background: Lipid peroxidation can be interpreting as an oxidative degeneration of lipids. It happens when a hydroxyl radical removes an electron from polyunsaturated fatty acids (PUFAs), which can react with oxygen and other polyunsaturated fatty acids to produceperoxyl radicals and hydroperoxides, thus promulgating the injury. So this repeat cycle of lipid peroxidation process can be responsible of cellular damage. Drug-induced lipid peroxidation is an important phenomenon found to be involved behind it’s certain hazardous side effects due to the generation toxic end products of such peroxidation like malonaldehyde (MA), hydroxynonenal (HNE), etc. Antioxidants play a crucial role in modifying such processes due to their free radical scavenging capability. Objective: Keeping in mind the matter, thisin vitroinvestigation was conducted using cefuroxime, a cephalosporin antibiotic as drug of choice and vitamin C as antioxidant taking liver tissue of goat as lipid source. Methods: The liver homogenate was divided in certain experimental groups that were treated with cefuroxime and ascorbic acid for specific time periods. The level of MA and HNE in the samples was estimated and compared with control. Result: The result showed that Cefuroxime has lipid peroxidation induction capability that was counteracted by ascorbic acid. Conclusion: Thus cefuroxime-induced, peroxidation associated, toxicities may be managed well upon co-administration with the antioxidant vitamin C.


Cite this article:
Madhurima Ghosh, Miltu Kumar Ghosh, Debabrata Devbhuti, Sandipan Dasgupta, Pritesh Devbhuti. An In vitro Study on impact of Vitamin-C on Cefuroxime mediated alterations in Bio-parameters associated with free Radical linked Lipid Decomposition. Research Journal of Pharmacy and Technology.2024; 17(4):1795-8. doi: 10.52711/0974-360X.2024.00285

Cite(Electronic):
Madhurima Ghosh, Miltu Kumar Ghosh, Debabrata Devbhuti, Sandipan Dasgupta, Pritesh Devbhuti. An In vitro Study on impact of Vitamin-C on Cefuroxime mediated alterations in Bio-parameters associated with free Radical linked Lipid Decomposition. Research Journal of Pharmacy and Technology.2024; 17(4):1795-8. doi: 10.52711/0974-360X.2024.00285   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-59


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