Author(s): Anne Ramu, Suryadevara Vidyadhara, Janga Ramesh Babu, Battula Sowjanya Lakshmi, Seelam Ramya Krishna

Email(s): ramuanne2601@gmail.com

DOI: 10.52711/0974-360X.2024.00284   

Address: Anne Ramu*, Suryadevara Vidyadhara, Janga Ramesh Babu, Battula Sowjanya Lakshmi, Seelam Ramya Krishna
Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur - 522019.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
The current research was to enhance solubility and dissolution rate of the slightly soluble drug, Olmesartan medoxomil, solid dispersions by physical mixing, solvent evaporation and kneading techniques, with soluplus. The solid dispersions prepared are tested for flow properties, drug content, and particle size. In vitro dissolution studies were carried out to analyse the drug release from solid dispersions. Crystal morphology, drug and polymer interaction for selected solid dispersions was studied by FT-IR and DSC analysis. Fast-dissolving tablets were formulated by using optimized solid dispersions using different concentrations of sodiumstarch glycolate, crosscarmellosesodium, and crospovidone as superdisintegrants using direct compression technique. The tablets prepared are tested for Weight variation, friability, disintegration, content uniformity and harness. The mechanism and kinetics of drug release from the fast-dissolving tablets were tested by in-vitro dissolution studies. The current research proves that combining solid dispersions along with the use of superdisintegrants is novel approach to formulate of Olmesartan medoxomil fast-dissolving tablets.


Cite this article:
Anne Ramu, Suryadevara Vidyadhara, Janga Ramesh Babu, Battula Sowjanya Lakshmi, Seelam Ramya Krishna. Formulation, Evaluation and Study of Super Disintegrants effect on Olmesartan Medoxomil Fast Dissolving Tablets. Research Journal of Pharmacy and Technology.2024; 17(4):1789-4. doi: 10.52711/0974-360X.2024.00284

Cite(Electronic):
Anne Ramu, Suryadevara Vidyadhara, Janga Ramesh Babu, Battula Sowjanya Lakshmi, Seelam Ramya Krishna. Formulation, Evaluation and Study of Super Disintegrants effect on Olmesartan Medoxomil Fast Dissolving Tablets. Research Journal of Pharmacy and Technology.2024; 17(4):1789-4. doi: 10.52711/0974-360X.2024.00284   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-58


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