Author(s): Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Ahmad Affan Ali Murtadlo, Maksim Rebezov, Nikolai Maksimiuk, Pavel Burkov, Marina Derkho, Elena Bobkova

Email(s): hery-p@fst.unair.ac.id

DOI: 10.52711/0974-360X.2024.00282   

Address: Viol Dhea Kharisma1,2, Arif Nur Muhammad Ansori1,3, Ahmad Affan Ali Murtadlo2, Maksim Rebezov4,5, Nikolai Maksimiuk6, Pavel Burkov7, Marina Derkho7, Elena Bobkova8, Evgeny Ponomarev8, Vikash Jakhmola9, Hery Purnobasuki1,10*
1Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
2Computational Virology Research Unit, Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, Indonesia.
3Professor Nidom Foundation, Surabaya, Indonesia.
4Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, Russian Federation.
5Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, Russian Federation.
6Institute of Medical Education, Yaroslav-the-Wise Novgorod State University, Velikiy Novgorod, Russian Federation.
7Institute of Veterinary Medicine, South Ural State Agrarian University, Troitsk, Russian Federation.
8K.G. Razum

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
Human immunodeficiency virus (HIV) is a genus of Lentivirus that triggers opportunistic diseases in the human body. HIV-1 has been a major problem for the world community for a long time and triggered a pandemic. HIV-1 antiviral drugs with the mechanism of inhibiting specific proteins have been found but have some harmful side effects for patients. Back to nature solutions can be used to solve these problems. Natural ingredients can be used as an alternative treatment for the treatment of HIV-1 infection allegedly more effective and minimal side effects. Antiviral candidate natural ingredients such as Garcinia mangostana L. with compounds consisting of Mangostin and Garcinone, the potential of Garcinone compounds is currently still unidentified. This study aims to reveal the potential of Garcinone derivative compounds from Garcinia mangostana L. as HIV-1 antiviral through the mechanism of reverse transcriptase inhibition with an in silico approach. The method used in this research is in silico simulation such as druglikeness analysis, molecular docking, chemical bond identification, and molecular stability. Garcinone A from Garcinia mangostana L. can be an HIV-1 antiviral candidate with a good molecular mechanism of inhibiting HIV-1 RT activity because it produces more negative binding affinity than the control drug and triggers stable binding interactions on the target.


Cite this article:
Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Ahmad Affan Ali Murtadlo, Maksim Rebezov, Nikolai Maksimiuk, Pavel Burkov, Marina Derkho, Elena Bobkova. Revealing Novel Antiretroviral Candidate from Garcinia mangostana L. againts HIV-1 Infection via Reverse Transcriptase Inhibition: In Silico Study. Research Journal of Pharmacy and Technology.2024; 17(4):1777-3. doi: 10.52711/0974-360X.2024.00282

Cite(Electronic):
Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Ahmad Affan Ali Murtadlo, Maksim Rebezov, Nikolai Maksimiuk, Pavel Burkov, Marina Derkho, Elena Bobkova. Revealing Novel Antiretroviral Candidate from Garcinia mangostana L. againts HIV-1 Infection via Reverse Transcriptase Inhibition: In Silico Study. Research Journal of Pharmacy and Technology.2024; 17(4):1777-3. doi: 10.52711/0974-360X.2024.00282   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-56


REFERENCES:
1.    Sharp PM, Hahn BH. Origins of HIV and the AIDS pandemic. Cold Spring Harb Perspect Med. 2011;1(1): a006841. DOI: 10.1101/cshperspect.a006841.
2.    Adhiambo M, Makwaga O, Adungo F, Kimani H, Mulama DH, Korir JC, Mwau M. Human immunodeficiency virus (HIV) type 1 genetic diversity in HIV positive individuals on antiretroviral therapy in a cross-sectional study conducted in Teso, Western Kenya. Pan Afr Med J. 2021; 38: 335. DOI: 10.11604/pamj.2021.38.335.26357.
3.    Rawat P, Teodorof-Diedrich C, Spector SA. Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. Glia. 2019; 67(5): 802-824. DOI: 10.1002/glia.23568.
4.    Giraldo DM, Hernandez JC, Urcuqui-Inchima S. HIV-1-derived single-stranded RNA acts as activator of human neutrophils. Immunol Res. 2016; 64(5-6): 1185-1194. DOI: 10.1007/s12026-016-8876-9.
5.    Vidya Vijayan KK, Karthigeyan KP, Tripathi SP, Hanna LE. Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections. Front Immunol. 2017; 8: 580. DOI: 10.3389/fimmu.2017.00580.
6.    Ratnam M, Nayyar AS, Reddy DS, Ruparani B, Chalapathi KV, Azmi SM. CD4 cell counts and oral manifestations in HIV infected and AIDS patients. J Oral Maxillofac Pathol. 2018; 22(2): 282. DOI: 10.4103/jomfp.JOMFP_191_17.
7.    Wang RR, Yang QH, Luo RH, Peng YM, Dai SX, Zhang XJ, Chen H, Cui XQ, Liu YJ, Huang JF, Chang JB, Zheng YT. Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. PLoS One. 2014; 9(8): e105617. DOI: 10.1371/journal.pone.0105617.
8.    Li G, Wang Y, De Clercq E. Approved HIV reverse transcriptase inhibitors in the past decade. Acta Pharm Sin B. 2022;12(4): 1567-1590. DOI: 10.1016/j.apsb.2021.11.009.
9.    Yu B, Chang J. Azvudine (FNC): a promising clinical candidate for COVID-19 treatment. Signal Transduct Target Ther. 2020; 5(1): 236. DOI: 10.1038/s41392-020-00351-z.
10.    Singh AK, Das K. Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies. Viruses. 2022;14(5):1027. DOI: 10.3390/v14051027.
11.    Xavier Ruiz F, Arnold E. Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance. Curr Opin Struct Biol. 2020; 61: 113-123. DOI: 10.1016/j.sbi.2019.11.011.
12.    Larsen KP, Mathiharan YK, Kappel K, Coey AT, Chen DH, Barrero D, Madigan L, Puglisi JD, Skiniotis G, Puglisi EV. Architecture of an HIV-1 reverse transcriptase initiation complex. Nature. 2018; 557(7703): 118-122. DOI: 10.1038/s41586-018-0055-9.
13.    Kim MJ, Kim SW, Chang HH, Kim Y, Jin S, Jung H, Park JH, Kim S, Lee JM. Comparison of Antiretroviral Regimens: Adverse Effects and Tolerability Failure that Cause Regimen Switching. Infect Chemother. 2015; 47(4): 231-8. doi: 10.3947/ic.2015.47.4.231.
14.    Hughes Y, Tomlins L, Usherwood T. Prescribing for patients taking antiretroviral therapy. Aust Prescr. 2022; 45(3): 80-87. DOI: 10.18773/austprescr.2022.026.
15.    Kelso-Chichetto NE, Okafor CN, Harman JS, Canidate SS, Cook CL, Cook RL. Complementary and Alternative Medicine Use for HIV Management in the State of Florida: Medical Monitoring Project. J Altern Complement Med. 2016; 22(11): 880-886. DOI: 10.1089/acm.2016.0190.
16.    Ansori ANM, Fadholly A, Hayaza S, Susilo RJK, Inayatillah B, Winarni D, Husen SA. A Review on Medicinal Properties of Mangosteen (Garcinia mangostana L.). Res J Pharm Techol. 2020; 13(2): 974-982. DOI: 10.5958/0974-360X.2020.00182.1
17.    Espirito Santo BLSD, Santana LF, Kato Junior WH, de Araújo FO, Bogo D, Freitas KC, Guimarães RCA, Hiane PA, Pott A, Filiú WFO, Arakaki Asato M, Figueiredo PO, Bastos PRHO. Medicinal Potential of Garcinia Species and Their Compounds. Molecules. 2020; 25(19): 4513. DOI: 10.3390/molecules25194513.
18.    Ben Hlima H, Farhat A, Akermi S, Khemakhem B, Ben Halima Y, Michaud P, Fendri I, Abdelkafi S. In silico evidence of antiviral activity against SARS-CoV-2 main protease of oligosaccharides from Porphyridium sp. Sci Total Environ. 2022; 836: 155580. DOI: 10.1016/j.scitotenv.2022.155580.
19.    Tungary E, Ongko J, Sukweenadhi J, Antonius Y. Molecular docking of active compounds from traditional medicinal plants as ACE-2 protein (1R4L) inhibitor in searching for COVID-19 drug. Res J Pharm Technol. 2022; 15(9): 4235-4240. DOI: 10.52711/0974-360X.2022.00712
20.    Antonius Y, Ongko J, Hardjo PH. Identification of potential activity of volatile compounds derived from Pogostemon cablin Benth as antiviral of SARS-CoV-2. Int J App Pharm. 2023; 15(1): 93-97. DOI: 10.22159/ijap.2023v15i1.43571
21.    Fadholly A, Ansori ANM, Utomo B. Anticancer Effect of Naringin on Human Colon Cancer (WiDr Cells): In Vitro Study. Research Journal of Pharmacy and Technology. 2022; 15(2): 885-888. DOI: 10.52711/0974-360X.2022.00148
22.    Husen SA, Wahyuningsih SPA, Ansori ANM, Hayaza S, Susilo RJK, Winarni D, Punnapayak H, Darmanto W. Antioxidant Potency of Okra (Abelmoschus esculentus Moench) Pods Extract on SOD Level and Tissue Glucose Tolerance in Diabetic Mice. Res J Pharm Technol. 12(12): 5683. DOI: 10.5958/0974-360X.2019.00983.1
23.    Husen SA, Setyawan MF, Syadzha MF, Susilo RJK, Hayaza S, Ansori ANM, Alamsjah MA, Ilmi ZN, Wulandari PAC, Pudjiastuti P, Awang P, Winarni D. A Novel Therapeutic effects of Sargassum ilicifolium Alginate and Okra (Abelmoschus esculentus) Pods extracts on Open wound healing process in Diabetic Mice. Research J. Pharm. and Tech 2020; 13(6): 2764-2770. DOI: 10.5958/0974-360X.2020.00491.6
24.    Kharisma VD, Kharisma SD, Ansori ANM, Kurniawan HP, Witaningrum AM, Fadholly A, Tacharina MR. Antiretroviral Effect Simulation from Black Tea (Camellia sinensis) via Dual Inhibitors Mechanism in HIV-1 and its Social Perspective in Indonesia. Res J Pharm Technol. 2021; 14(1): 455-460. DOI: 10.5958/0974-360X.2021.00083.4
25.    Fadholly A, Ansori ANM, Kharisma VD, Rahmahani J, Tacharina MR. Immunobioinformatics of Rabies Virus in Various Countries of Asia: Glycoprotein Gene. Res J Pharm Technol. 2021; 14(2): 883-886. DOI: 10.5958/0974-360X.2021.00157.8
26.    Ansori ANM, Fadholly A, Proboningrat A, Hayaza S, Susilo RJK, Naw SW, Posa GAV, Yusrizal YF, Sibero MT, Sucipto TH, Soegijanto S. In vitro antiviral activity of Pinus merkusii (Pinaceae) stem bark and cone against dengue virus type-2 (DENV-2). Res J Pharm Technol. 2021; 14(7): 3705-8. DOI: 10.52711/0974-360X.2021.00641
27.    Ansori ANM, Kharisma VD, Fadholly A, Tacharina MR, Antonius Y, Parikesit AA. Severe Acute Respiratory Syndrome Coronavirus-2 Emergence and Its Treatment with Alternative Medicines: A Review. Research Journal of Pharmacy and Technology 2021; 14(10): 5551-7. DOI: 10.52711/0974-360X.2021.00967
28.    Husen SA, Ansori ANM, Hayaza S, Susilo RJK, Zuraidah AA, Winarni D, Punnapayak H, Darmanto W. Therapeutic Effect of Okra (Abelmoschus esculentus Moench) Pods Extract on Streptozotocin-Induced Type-2 Diabetic Mice. Res J Pharm Technol. 2019; 12(8): 3703-3708. DOI: 10.5958/0974-360X.2019.00633.4
29.    Ansori ANM, Kharisma VD, Solikhah TI. Medicinal properties of Muntingia calabura L.: A Review. Res J Pharm Technol. 2021; 14(8):4509-2. DOI: 10.52711/0974-360X.2021.00784
30.    Fadholly A, Ansori ANM, Sucipto TH. An overview of naringin: Potential anticancer compound of citrus fruits. Research Journal of Pharmacy and Technology. 2020; 13(11): 5613-5619. DOI: 10.5958/0974-360X.2020.00979.8
31.    Proboningrat A, Kharisma VD, Ansori ANM, Rahmawati R, Fadholly A, Posa GAV, Sudjarwo SA, Rantam FA, Achmad AB. In silico Study of Natural inhibitors for Human papillomavirus-18 E6 protein. Res J Pharm Technol. 2022; 15(3): 1251-6. DOI: 10.52711/0974-360X.2022.00209
32.    Ramadhani NF, Nugraha AP, Ihsan IS, Agung YA, Rantam FA, Ernawati DS et al. Gingival medicinal signaling cells conditioned medium effect on the osteoclast and osteoblast number in lipopolysaccharide-induced calvaria bone resorption in wistar rats’ (Rattus novergicus). Research Journal of Pharmacy and Technology. 2021; 14(10): 5232-5237. DOI: 10.52711/0974-360X.2021.00911
33.    Kharisma VD, Ansori ANM, Jakhmola V, Rizky WC, Widyananda MH, Probojati RT, Murtadlo AAA, Rebezov M, Scherbakov P, Burkov P, Matrosova Y, Romanov A, Sihombing MAEM, Antonius Y, Zainul R. Multi-strain human papillomavirus (HPV) vaccine innovation via computational study: A mini review. Res J Pharm Technol. 2022; 15(8): 3802-7. DOI: 10.52711/0974-360X.2022.00638
34.    Fahmi M, Kharisma VD, Ansori ANM, Ito M. Retrieval and Investigation of Data on SARS-CoV-2 and COVID-19 Using Bioinformatics Approach. Adv Exp Med Biol. 2021; 1318: 839-857. DOI: 10.1007/978-3-030-63761-3_47
35.    Kharisma VD, Probojati RT, Murtadlo AAA, Ansori ANM, Antonius Y, Tamam MB. Revealing Potency of Bioactive Compounds as Inhibitor of Dengue Virus (DENV) NS2B/NS3 Protease from Sweet Potato (Ipomoea batatas L.) Leaves. Indian J Forensic Med Toxicol. 2020; 15(1): 1627–1632. DOI: 10.37506/ijfmt.v15i1.13644
36.    Husen SA, Winarni D, Salamun, Ansori ANM, Susilo RJK, Hayaza S. Hepatoprotective Effect of Gamma-mangostin for Amelioration of Impaired Liver Structure and Function in Streptozotocin-induced Diabetic Mice. IOP Conference Series: Earth and Environmental Science. 2019; 217(1): 012031. DOI: 10.1088/1755-1315/217/1/012031
37.    Turista DDR, Islamy A, Kharisma VD, Ansori ANM. Distribution of COVID-19 and Phylogenetic Tree Construction of SARS-CoV-2 in Indonesia. J Pure Appl Microbiol. 2020; 14: 1035-1042. DOI: 10.22207/JPAM.14.SPL1.42
38.    Kharisma VD, Widyananda MH, Ansori ANM, Nege AS, Naw SW, Nugraha AP Tea catechin as antiviral agent via apoptosis agonist and triple inhibitor mechanism against HIV-1 infection: A bioinformatics approach. J Pharm Pharmacogn Res. 9(4): 435-445.
39.    Kharisma VD, Ansori ANM, Nugraha AP. Computational study of ginger (Zingiber Officinale) as E6 inhibitor in human papillomavirus type 16 (Hpv-16) infection. Biochemical and Cellular Archives. 2020; 20: 3155-3159. DOI: 10.35124/bca.2020.20.S1.3155
40.    Ansori  ANM, Kharishma VD, Muttaqin SS, Antonius Y, Parikesit AA. Genetic Variant of SARS-CoV-2 Isolates in Indonesia: Spike Glycoprotein Gene. J Pure Appl Microbiol. 2020; 14: 971-978. DOI: 10.22207/JPAM.14.SPL1.35
41.    Widyananda MH, Pratama SK, Samoedra RS, Sari FN, Kharisma VD, Ansori ANM, Antonius Y. Molecular docking study of sea urchin (Arbacia lixula) peptides as multi-target inhibitor for non-small cell lung cancer (NSCLC) associated proteins. J Pharm Pharmacogn Res. 2021; 9(4): 484–496.
42.    Kharisma VD, Ansori ANM. Construction of Epitope-Based Peptide Vaccine Against SARS-CoV-2: Immunoinformatics Study. J Pure Appl Microbiol. 2020; 14: 999-1005. DOI: 10.22207/JPAM.14.SPL1.38
43.    Kharisma VD, Ansori ANM, Widyananda MH, Utami SL, Nugraha AP. Molecular simulation: The potency of conserved region on E6 HPV-16 as a binding target of black tea compounds against cervical cancer. Biochemical and Cellular Archives. 2020; 20: 2795-2802. DOI: 10.35124/bca.2020.20.S1.2795
44.    Kharisma VD, Agatha A, Ansori ANM, Widyananda MH, Rizky WC, Dings TGA, Derkho M, Lykasova I, Antonius Y, Rosadi I, Zainul R. Herbal combination from Moringa oleifera Lam. and Curcuma longa L. as SARS-CoV-2 antiviral via dual inhibitor pathway: A viroinformatics approach. J Pharm Pharmacogn Res. 2022; 10(1): 138-146. DOI: 10.56499/jppres21.1174_10.1.138
45.    Khairullah AR, Solikhah TI, Ansori ANM, Hanisia RH, Puspitarani GA, Fadholly A, Ramandinianto SC. Medicinal importance of Kaempferia galanga L. (Zingiberaceae): A comprehensive review. J Herbmed Pharmacol. 2021; 10: 281-288. DOI: 10.34172/jhp.2021.32
46.    Husen SA, Syadzha MF, Setyawan MF, Pudjiastuti P, Ansori ANM, Susilo RJK et al. Evaluation of the combination of sargassum duplicatum, sargassum ilicifolium, abelmoschus esculentus, and garcinia mangostana extracts for open wound healing in diabetic mice. Systematic Reviews in Pharmacy. 2020; 11(9): 888-892. DOI: 10.31838/srp.2020.9.129
47.    Wijaya RM, Hafidzhah MA, Kharisma VD, Ansori ANM, Parikesit AP. COVID-19 In Silico Drug with Zingiber officinale Natural Product Compound Library Targeting the Mpro Protein. Makara J Sci. 2021; 25(3): 5. DOI: 10.7454/mss.v25i3.1244
48.    Ansori ANM, Fadholly A, Kharisma VD, Nugraha AP. Therapeutic potential of avian paramyxovirus serotype 1 for cancer therapy. Biochemical and Cellular Archives. 2020;20:2827-2832. DOI: 10.35124/bca.2020.20.S1.2827
49.    Prahasanti C, Nugraha AP, Kharisma VD, Ansori ANM, Ridwan RD, Putri TPS et al. Un enfoque bioinformático de la exploración con compuestos de hidroxiapatita y polimetilmetacrilato como biomaterial de implantes dentales. Journal of Pharmacy and Pharmacognosy Research. 2021; 9(5): 746-754.
50.    Kharisma VD, Ansori ANM, Fadholly A, Sucipto TH. Molecular mechanism of caffeine-aspirin interaction in kopi balur 1 as anti-inflammatory agent: A computational study. Indian Journal of Forensic Medicine and Toxicology. 2020; 14(4): 4040-4046. DOI: 10.37506/ijfmt.v14i4.12274
51.    Kharisma VD, Widodo N, Ansori ANM, Nugraha AP. A vaccine candidate of zika virus (ZIKV) from polyvalent conserved b-cell epitope on viral glycoprotein: In silico approach. Biochemical and Cellular Archives. 2020; 20: 2785-2793. DOI: 10.35124/bca.2020.20.S1.2785
52.    Ansori ANM, Kharisma VD, Nugraha AP. Phylogenetic and pathotypic characterization of avian paramyxovirus serotype 1 (APMV-1) in Indonesia. Biochemical and Cellular Archives. 2020; 20: 3023-3027. https://doi.org/10.35124/bca.2020.20.S1.3023
53.    Padmi H, Kharisma VD, Ansori ANM, Sibero MT, Widyananda MH, Ullah E, Gumenyuk O, Chylichcova S, Bratishko N, Prasedya ES, Sucipto TH, Zainul R. Macroalgae Bioactive Compounds for the Potential Antiviral of SARS-CoV-2: An In Silico Study. Journal of Pure and Applied Microbiology. 2022; 16(2): 1018-1027. DOI: 10.22207/JPAM.16.2.26
54.    Antonius Y, Kharisma VD, Widyananda MH, Ansori ANM, Trinugroho JP, Ullah ME, Naw SW, Jakhmola V, Wahjudi M. Prediction of Aflatoxin-B1 (AFB1) Molecular Mechanism Network and Interaction to Oncoproteins Growth Factor in Hepatocellular Carcinoma. J Pure Appl Microbiol. 2022; 16(3): 1844-1854. doi: 10.22207/JPAM.16.3.29
55.    Dibha AF, Wahyuningsih S, Ansori ANM, Kharisma VD, Widyananda MH, Parikesit AA, Sibero MT, Probojati RT, Murtadlo AAA, Trinugroho JP, Sucipto TH, Turista DDR, Rosadi I, Ullah ME, Jakhmola V, Zainul R. Utilization of Secondary Metabolites in Algae Kappaphycus alvarezii as a Breast Cancer Drug with a Computational Method. Pharmacognosy Journal. 2022; 14(3): 536-543. DOI: 10.5530/pj.2022.14.68
56.    Aini NS, Ansori ANM, Kharisma VD, Syadzha MF, Widyananda MH, Murtadlo AA, et al. Potential Roles of Purslane (Portulaca oleracea L.) as Antimetabolic Syndrome: A Review. Pharmacognosy Journal. 2022; 14(3): 710-714. DOI: 10.5530/pj.2022.14.90
57.    Listiyani P, Kharisma VD, Ansori AN, Widyananda MH, Probojati RT, Murtadlo AA, et al. In Silico Phytochemical Compounds Screening of Allium sativum Targeting the Mpro of SARS-CoV-2. Pharmacognosy Journal. 2022; 14(3): 604-609. DOI: 10.5530/pj.2022.14.78
58.    Aini NS, Kharisma VD, Widyananda MH, Murtadlo AA, Probojati RT, Turista DD, et al. In Silico Screening of Bioactive Compounds from Syzygium cumini L. and Moringa oleifera L. Against SARS-CoV-2 via Tetra Inhibitors. Pharmacognosy Journal. 2022;14(4): 267-272. DOI: 10.5530/pj.2022.14.95
59.    Aini NS, Kharisma VD, Widyananda MH, Murtadlo AA, Probojati RT, Turista DD, et al. Bioactive Compounds from Purslane (Portulaca oleracea L.) and Star Anise (Illicium verum Hook) as SARS-CoV-2 Antiviral Agent via Dual Inhibitor Mechanism: In Silico Approach. Pharmacognosy Journal. 2022; 14(4): 352-357. DOI: 10.5530/pj.2022.14.106
60.    Ansori ANM, Fadholly A, Proboningrat A, Antonius Y, Hayaza S, Susilo RJ, Inayatillah B, Sibero MT, Naw SW, Posa GAV, Sucipto TH, Soegijanto S. Novel Antiviral Investigation of Annona squamosa Leaf Extract against the Dengue Virus Type-2: In vitro Study. Phcog J. 2021; 13(2): 456-462. DOI: 10.5530/pj.2021.13.58
61.    Ansori AN, Kharisma VD, Parikesit AA, Dian FA, Probojati RT, Rebezov M, Scherbakov P, Burkov P, Zhdanova G, Mikhalev A, Antonius Y, Pratama MRF, Sumantri NI, Sucipto TH, Zainul R. Bioactive Compounds from Mangosteen (Garcinia mangostana L.) as an Antiviral Agent via Dual Inhibitor Mechanism against SARS-CoV- 2: An In Silico Approach. Phcog J. 2022; 14(1): 85-90. DOI: 10.5530/pj.2022.14.12
62.    Wicaksono A, Kharisma VD, Parikesit AA. New Perspectives on Reverse Translation: Brief History and Updates, Universitas Scientiarum. 2023l 28(1): 1–20, 2. DOI: 10.11144/Javeriana.SC281.npor

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available