Author(s): Jainey P. James, Leema Crasta, Veeksha Shetty, Divya Jyothi, Mariyam Jouhara, Zakiya Fathima C, Sindhu T. J., Keerthan

Email(s): jaineyjames@gmail.com , jaineyjames@nitte.edu.in

DOI: 10.52711/0974-360X.2024.00280   

Address: Jainey P. James1*, Leema Crasta1, Veeksha Shetty1, Divya Jyothi2, Mariyam Jouhara1, Zakiya Fathima C1, Sindhu T. J.1, Keerthan1 1Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore - 575018, Karnataka, India.
2Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore - 575018, Karnataka, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
The study aimed to determine the tyrosinase and peroxiredoxin inhibitory action of ethanolic extracts of Memecylon malabaricum leaves. The phytoconstituents present in Memecylon malabaricum were analysed for their inhibitory activity against the tyrosinase and peroxiredoxin enzymes by molecular docking, and their molecular interactions were confirmed. The Qikprop module checked their pharmacokinetic profiles. The ethanolic extracts were prepared, and they were analysed for antityrosinase and antioxidant activity by in vitro methods. All the fourteen phytoconstituents obtained from Memecylon malabaricum were docked with two proteins, tyrosinase (5I38) and peroxiredoxin (1HD2), and MM1 was the well-interacted compound. The ethanolic extract was evaluated for tyrosinase inhibitory activity and antioxidant activity using the DPPH radical scavenging method and was compared with the standard ascorbic acid. It was concluded that the ethanolic extract of Memecylon malabaricum was active, and further pharmacological studies were needed to confirm their potency.


Cite this article:
Jainey P. James, Leema Crasta, Veeksha Shetty, Divya Jyothi, Mariyam Jouhara, Zakiya Fathima C, Sindhu T. J., Keerthan. Tyrosinase and Peroxiredoxin Inhibitory Action of Ethanolic Extracts of Memecylon malabaricum Leaves. Research Journal of Pharmacy and Technology.2024; 17(4):1763-0. doi: 10.52711/0974-360X.2024.00280

Cite(Electronic):
Jainey P. James, Leema Crasta, Veeksha Shetty, Divya Jyothi, Mariyam Jouhara, Zakiya Fathima C, Sindhu T. J., Keerthan. Tyrosinase and Peroxiredoxin Inhibitory Action of Ethanolic Extracts of Memecylon malabaricum Leaves. Research Journal of Pharmacy and Technology.2024; 17(4):1763-0. doi: 10.52711/0974-360X.2024.00280   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-54


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