Author(s): Nimmathota Madhavi, Beeravelli Sudhakar

Email(s): nimmathota.madhavi@gmail.com

DOI: 10.52711/0974-360X.2024.00267   

Address: Nimmathota Madhavi1*, Beeravelli Sudhakar2
1Department of Pharmaceutics, CMR College of Pharmacy, Affiliated to JNTUH, Hyderabad, Telangana, India - 501401,
2Department of Pharmaceutics, AU College of Pharmaceutical Science, Andhra University, Visakhapatnam, Andhra Pradesh - 530003, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
The etodolac based modified karaya gum (MKG) gel was developed using 32 factorial design to enhance the therapeutic effect of gel to treat inflammation. Gels were prepared with different concentrations of MKG and arachis oil using 32 factorial design. The percentage of drug content was found in the range of 96 to 99%, viscosity results shown in the range of 842 CPS to 2560 CPS and in vitro drug release was found to be in range of 38% to 98% respectively. Whereas ex-vivo permeation studies of etodolac gel and pure etodolac solution across the burned pig skin were shown 72% and 42% respectively. The drug and excipient compatibility studies by FTIR confirms that, there is no major functional group change was observed. The results concluded that, the combination of MKG and arachis oil were improved the penetration of etodolac through burned pig skin thereby the combination of PE and oil successfully enhanced the therapeutic effect of etodolac.


Cite this article:
Nimmathota Madhavi, Beeravelli Sudhakar. Impact of Penetration Enhancer and Natural Oil on Transdermal Delivery of Modified Karaya Gum Gel. Research Journal of Pharmacy and Technology.2024; 17(4):1685-1. doi: 10.52711/0974-360X.2024.00267

Cite(Electronic):
Nimmathota Madhavi, Beeravelli Sudhakar. Impact of Penetration Enhancer and Natural Oil on Transdermal Delivery of Modified Karaya Gum Gel. Research Journal of Pharmacy and Technology.2024; 17(4):1685-1. doi: 10.52711/0974-360X.2024.00267   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-41


REFERENCES:
1.    Sajid Ali, Maryam Shabbir, Nabeel Shahid. The Structure of Skin and Transdermal Drug Delivery System- A Review. Research J. Pharm and Tech. 2015; 8(2): 103-109. doi: 10.5958/0974-360X.2015.00019.0
2.    Prajapati VD, Jani GK, Moradiya NG, Randeria NP. Pharmaceutical applications of various natural gums, mucilages and their modified forms. Carbohydr Polym. 2013; 92(2): 1685-99.  doi: 10.1016/j.carbpol.2012.11.021
3.    Krishna Kumari J, Bandaru Hemanth Kumar, Prasanthi D. Natural Gums and Mucilage as Gelling agents in Topical Gel Formulation. Research J. Pharm and Tech.  2022; 15(10): 4681-6. doi: 10.52711/0974-360X.2022.00785
4.    Bhairam Monika, Roy Amit, Bahadur Sanjib, Banafar Alisha, Patel Mihir, Turkane Dhanushram. Transdermal Drug Delivery System with Formulation and Evaluation Aspects: Overview. Research J. Pharm. and Tech. 2012; 5(9): 1168-1176.
5.    Murali Mohan Babu GV, Kumar NR, Sankar KH, Ram BJ, Kumar NK, Murthy KV. In vivo evaluation of modified gum karaya as a carrier for improving the oral bioavailability of a poorly water-soluble drug, nimodipine. AAPS PharmSciTech. 2002; 3(2): E12. doi: 10.1208/pt030212
6.    Nguyen Duc Hanh, Le Van Thinh, Do Quang Duong. Development and Evaluation of Neem Gel Formulation using Gum Karaya as Gelling Agent. Research J. Pharm. and Tech. 2020; 13(4): 1859-1864. doi: 10.5958/0974-360X.2020.00335.2
7.    Vijay Singh Jatav, Jitendra Singh Saggu, Ashish Kumar Sharma, Santosh Kumar Singh. Effect of Dimethyl Sulphoxides as Permeation Enhancer on Transdermal Patch of Nebivolol Hydrochloride. Asian J. Res. Pharm. Sci. 2013; 3(1): 08-11.
8.    Panval AV, Chaudhari BP, Velhal AB, Redasani VK. Novel Tool for Controlled Delivery: Transdermal Drug Delivery System. Asian J. Res. Pharm. Sci. 2022; 12(4):304-8. doi: 10.52711/2231-5659.2022.00052
9.    Suchita Prabhakar Dhamane, Swati Chagdeo Jagdale. Development of Rifampicin loaded Chitosan nanoparticles by 32 full Factorial design. Research J. Pharm. and Tech. 2020; 13(6): 2545-2550. doi: 10.5958/0974-360X.2020.00453.9
10.    Amar Gangadhar Zalte, Ravindranath Bhanudas Saudagar. Preparation and Characterization of Etodolac Co-Crystals Using 32 Full Factorial Design. Research J. Pharm. and Tech. 2018; 11(9): 3781-3786. doi: 10.5958/0974-360X.2018.00693.5
11.    Manmohan S. Jangdey, Anshita Gupta, Abhishek K. Sah. Formulation and Evaluation of Sustained Release Topical Gel of Flurbiprofen Using Natural Polymers. Research J. Topical and Cosmetic Sci. 2014; 5(1): 7-11.
12.    Saranya R, Elango K, Devi Damayanthi N, Balaguru A. Formulation and Evaluation of Hydrogel for Stomach Specific Drug Delivery of Lamivudine. Research J. Pharm. and Tech. 2013; 6(7): 740-745.
13.    Barbero AM, Frasch HF. Pig and guinea pig skin as surrogates for human in vitro penetration studies: a quantitative review. Toxicol In Vitro. 2009; 23(1): 1-13. doi: 10.1016/j.tiv.2008.10.008
14.    Gupta R, Dwadasi B, Rai B.  Effect of Chemical Permeation Enhancers on Skin Permeability: In silico screening using Molecular Dynamics simulations. Sci Rep. 2019, 9, 1-11. doi.org/10.1038/s41598-018-37900-0





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