Author(s): Utkarsh Shastri, Kishori P. Sutar, Vishwanath A Jadhav, Nisha S. Shirkoli

Email(s): kishorisutar@klepharm.edu

DOI: 10.52711/0974-360X.2024.00230   

Address: Utkarsh Shastri1, Kishori P. Sutar1*, Vishwanath A Jadhav1, Nisha S. Shirkoli2
1Department of Pharmaceutics, KLE College of Pharmacy Belagavi. KLE Academy Higher Education and Research, Nehru Nagar, Belagavi-590010, Karnataka, India.
2Department of Quality assurance, KLE College of Pharmacy, Belagavi. KLE Academy Higher Education and Research, Nehru Nagar, Belagavi-590010, Karnataka, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
Purpose The study aims to use liquisolid compacts technology as a novel carrier to enhance Ticagrelor's solubility and release profile. Method: Formulation of liquisolid tablets was developed using the Design of Experiment (DOE) approach where the drug Ticagrelor was dispersed in PEG-600 and incorporated into carrier material (Neusilin US2) in the mortar, the liquid drug was permitted to absorb in the second stage. Aerosil-200 was used as a coating material, and Magnesium stearate and Sodium starch Glycolate were used as Lubricant and Disintegrating Agent respectively. The formulations were optimized and the carrier-to-coating ratio and mixing Aerosil-200 with Neusilin US2 effect on drug release from the formulation was investigated. The prepared liquisolid compacts were subjected to micrometric characterization, post-compression parameters, Fourier Transform Infrared Spectroscopy (FTIR), and Differential Scanning Calorimetry (DSC). Result: The cumulative drug release of all formulations in dissolution media varies from 82% to 96% and Formulation F9 showed a maximum cumulative drug release of about 96%. The drug contents of all formulations ranged from 91.06% to 99.01%. Disintegration time for all 1-9 formulations, clearly, all compositions disintegrate in less than 10 minutes. The cumulative drug release of all formulations varies from 82% to 96% Formulation F9 showed a maximum cumulative drug release of about 96% and the conventional tablet showed a cumulative drug release of about 80 %. The optimized liquisolid formulation F8 outperformed the other batches in terms of flow and compressibility across all formulations. Conclusion: Therefore, as per the results, it can be inferred that Ticagrelor, when formulated by a liquisolid approach, produce ameliorated dissolution and stability profile.


Cite this article:
Utkarsh Shastri, Kishori P. Sutar, Vishwanath A Jadhav, Nisha S. Shirkoli. Formulation, Optimization and Evaluation of Ticagrelor Liquisolid Tablets for Enhanced Solubility. Research Journal of Pharmacy and Technology.2024; 17(4):1453-0. doi: 10.52711/0974-360X.2024.00230

Cite(Electronic):
Utkarsh Shastri, Kishori P. Sutar, Vishwanath A Jadhav, Nisha S. Shirkoli. Formulation, Optimization and Evaluation of Ticagrelor Liquisolid Tablets for Enhanced Solubility. Research Journal of Pharmacy and Technology.2024; 17(4):1453-0. doi: 10.52711/0974-360X.2024.00230   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-4


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