Author(s): Hany Akeel Al-Hussaniy, Ali Al-Samydai, Maha N. Abu Hajleh, Amal Mayyas, Amjad I. Oraibi

Email(s): , ,

DOI: 10.52711/0974-360X.2024.00265   

Address: Hany Akeel Al-Hussaniy1*, Ali Al-Samydai2, Maha N. Abu Hajleh3, Amal Mayyas4, Amjad I. Oraibi5
1Dr Hany Akeel Institute, Iraqi Medical Research Center, Baghdad, Iraq.
2Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.
3Department of Cosmetic Science, Pharmacological and Diagnostic Research Centre, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, 19328 Amman, Jordan.
4Department of Pharmacy, Faculty of Health Sciences, American University of Madaba, Madaba 11821, Jordan.
5Department of Pharmacy, Al-Manara College for Medical Sciences, Amarah, Iraq.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024

Dementia is a major health problem among the elderly around the world; the number of dementia patients, as well as antidementia drugs, has been increasing in recent years. In this paper, we searched the dementia treatment guidelines, domestic and foreign literature reports in the past five years, summarized the classification of dementia, the selection of current pharmacotherapies in dementia, evidence-based evaluation of guidelines and some drugs with clinical treatment prospects to provide a reference for the decision-making of dementia drug therapy.

Cite this article:
Hany Akeel Al-Hussaniy, Ali Al-Samydai, Maha N. Abu Hajleh, Amal Mayyas, Amjad I. Oraibi. Selection and Progress of drugs for treating Dementia. Research Journal of Pharmacy and Technology.2024; 17(4):1674-8. doi: 10.52711/0974-360X.2024.00265

Hany Akeel Al-Hussaniy, Ali Al-Samydai, Maha N. Abu Hajleh, Amal Mayyas, Amjad I. Oraibi. Selection and Progress of drugs for treating Dementia. Research Journal of Pharmacy and Technology.2024; 17(4):1674-8. doi: 10.52711/0974-360X.2024.00265   Available on:

1.    Rost NS, Meschia JF, Gottesman R, Wruck L, Helmer K, Greenberg SM, Discovery Investigators. Cognitive impairment and dementia after stroke: design and rationale for the Discovery study. Stroke. 2021 Aug;52(8):e499-516.
2.    Tawfeeq KT, Al-Khalidi GZ, Al-hussaniy HA. Neurodevelopmental Abnormalities in Children Associated with Maternal Use of Psychoactive Medication: Maternal Use of Psychoactive Medication. Medical and Pharmaceutical Journal. 2022; 1(2):64-73.
3.    Al-Hussaniy HA. The Effect of MicroRNA-409-3p for Treatment and Response to Tumor Proliferation of Lung Cancer Cell Lines (In Vitro). Asian Pacific Journal of Cancer Prevention: APJCP. 2022; 23(9):3151.
4.    Yin, Y., Tam, H. L., Quint, J., Chen, M., Ding, R., and Zhang, X. Epidemiology of Dementia in China in 2010–2020: A Systematic Review and Meta-Analysis. Healthcare. 2023; 12(3): 334.
5.    Al-hussainy HA, AL-Biati HA, Ali IS. The Effect of Nefopam Hydrochloride on the Liver, Heart, and Brain of Rats: Acute Toxicity and Mechanisms of Nefopam Toxicity. Journal of Pharmaceutical Negative Results. 2022; 13(3): 393-400.    
6.    Corasaniti MT, Bagetta G, Nicotera P, Maione S, Tonin P, Guida F, Scuteri D. Exploitation of Autophagy Inducers in the Management of Dementia: A Systematic Review. International Journal of Molecular Sciences. 2024; 25(2): 1264.
7.    Emrani S, Lamar M, Price CC, Wasserman V, Matusz E, Au R, Swenson R, Nagele R, Heilman KM, Libon DJ. Alzheimer’s/vascular spectrum dementia: Classification in addition to diagnosis. Journal of Alzheimer's disease. 2020; 73(1): 63-71.
8.    Tahami Monfared AA, Meier G, Perry R, Joe D. Burden of Disease and Current Management of Dementia with Lewy Bodies: A Literature Review. Neurol Ther. 2019; 8(2): 289-305. doi:10.1007/s40120-019-00154-7
9.    Salim Mahmood A, Ammoo AM, Ali MH, Hameed TM, Al-Hussaniy HA, Aljumaili AA, Al-Fallooji MH, Kadhim AH. Antiepileptic Effect of Neuroaid® on Strychnine-Induced Convulsions in Mice. Pharmaceuticals. 2022; 15(12): 1468.
10.    Ahmed MS, Reyadh AR, Shareef BQ, Ali AR, Hany AH, Meena AN. Increasing Prevalence of Congenital Hypothyroidism in children with Down Syndrome who have a family history of Thyroid disease. Research Journal of Pharmacy and Technology. 2023; 16(3): 1327-32.
11.    Al-hussaniy HA, Al-Shammari AH, Sameer HN, Oraibi AI.  The relationship between statin therapy and adipocytokine/ inflammatory mediators in dyslipidemic nondiabetic patients: A comparative study. Pharmacia. 2023; 70(3): 581-5.
12.    Carrarini C, Russo M, Dono F, Barbone F, Rispoli MG, Ferri L, Di Pietro M, Digiovanni A, Ajdinaj P, Speranza R, Granzotto A. Agitation and dementia: prevention and treatment strategies in acute and chronic conditions. Frontiers in Neurology. 2021; 12: 644317.
13.    Al_hussaniy HA, Alkhafaje Z, Altamimi ZS, Oraibi AI, Abdalhassan AH, Abdulhamza HM, AL-Zobaidy MJ.  Memantine and its role in parkinsonism, seizure, depression, migraine headache, and Alzheimer’s disease. Pharmacia. 2023;70(2):291-7.
14.    Awad M, Al-Hussaniy HA, Alburghaif AH, Tawfeeq KT. The role of COVID-19 in myopathy: incidence, causes, treatment, and prevention. Journal of Medicine and Life. 2022; 15(12): 1458.
15.    Dembitsky VM, Dzhemileva L, Gloriozova T, D’yakonov V. Natural and synthetic drugs used for the treatment of dementia. Biochemical and Biophysical Research Communications. 2020; 524(3): 772-83.
16.    Arjmandi-Rad S, Vestergaard Nieland JD, Goozee KG, Vaseghi S. The effects of different acetylcholinesterase inhibitors on EEG patterns in patients with Alzheimer’s disease: A systematic review. Neurological Sciences. 2023: 1-4.
17.    Katsayal BS, Lema AA, Jibrin K, Nuraddeen W, Alexander EM, Mohammed NH. Ameliorative Role of Nutraceutical Quercetin and its Derivatives Against Cognitive Impairment Process Induced by Lead Exposure in Drosophila melanogaster (Fruit Fly). Iraqi Journal of Pharmaceutical Sciences. 2021; 30(2): 135-42.
18.    Sridhar GR. Acetylcholinesterase inhibitors (Galantamine, Rivastigmine, and Donepezil). Neuro Psychopharmacotherapy. 2020: 1-3.
19.    Sutthapitaksakul L, Dass CR, Sriamornsak P. Donepezil—An updated review of challenges in dosage form design. Journal of Drug Delivery Science and Technology. 2021; 63: 102549.
20.    Saeedi M, Mehranfar F. Challenges and Approaches of Drugs Such as Memantine, Donepezil, Rivastigmine, and Aducanumab in the Treatment, Control and Management of Alzheimer's Disease. Recent Patents on Biotechnology. 2022; 16(2): 102-21.
21.    Marucci G, Buccioni M, Dal Ben D, Lambertucci C, Volpini R, Amenta F. Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease. Neuropharmacology. 2021; 190: 108352.
22.    Pasrija P, Girdhar M, Kumar M, Arora S, Katyal A. Endophytes: An unexplored treasure to combat Multidrug resistance. Phytomedicine Plus. 2022; 2(2): 100249.
23.    Zhou J, Liu Z, Wang S, Li J, Li Y, Chen WK, Wang R. Fungal endophytes promote the accumulation of Amaryllidaceae alkaloids in Lycoris radiata. Environmental microbiology. 2020; 22(4): 1421-34.
24.    Friedli MJ, Inestrosa NC. Huperzine A and its neuroprotective molecular signaling in Alzheimer’s disease. Molecules. 2021; 26(21): 6531.
25.    Ghassab‐Abdollahi N, Mobasseri K, Dehghani Ahmadabad A, Nadrian H, Mirghafourvand M. The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews. Phytotherapy Research. 2021;35(9):4971-87.
26.    Al-Hussaniy HA, Alburghaif AH, AL-Zobaidy MA, Alkuraishy HM, Mostafa-Hedeab G, Azam F, Al-Samydai AM, Al-tameemi ZS, Naji MA. Chemotherapy-induced cardiotoxicity: a new perspective on the role of Digoxin, ATG7 activators, Resveratrol, and herbal drugs. Journal of Medicine and Life. 2023; 16(4):491.
27.    Al-Hussaniy HA, Al-Tameemi ZS, Al-Zubaidi BA, Oraibi AI, Naji FA, Kilani S. Pharmacological properties of Spirulina species: Hepatoprotective, antioxidant and anticancer effects. Farmacia. 2023; 71(4): 670-8.
28.    Rana S, Sharma N, Dutt S, Patil RD. Hepatoprotective Effects of Carissa spinarum Extract on Carbon Tetra Chloride Induced Liver Damage in Zebrafish (Danio rerio). Medical and Pharmaceutical Journal. 2023 ;2(4): 206-20.
29.    Szöke É, Kéry Á, Lemberkovics É. Biological Activity OF Compounds of Plant Origin. InFrom Herbs to Healing: Pharmacognosy Phytochemistry Phytotherapy Biotechnology.  2023: 411-511.  
30.    Deng C, Chen H, Meng Z, Meng S. Gastrodin and vascular dementia: advances and current perspectives. Evidence-Based Complementary And Alternative Medicine. 2022; 2022.
31.    Al-Haddad M, Bairam A, Hussain H, Majeed S, Al-Jalehawi A. Evaluation of clinical efficacy of Ginkgo biloba extract in the treatment of knee osteoarthritis: a randomized clinical trial. F1000 Research. 2023 ;11:1231.
32.    Smeda H, Almakrabi N, Hassan R, Algool S. Evaluation of Knowledge, Attitude and Practice of Self-Medication among Pharmacy University Students: A Cross-Sectional Study in Zawia, Libya. Medical and Pharmaceutical Journal. 2023; 2(4):193-205.
33.    Noorulla SM, Roshan S. Nootropic and anti-bacterial activity of Olea europaea. Research Journal of Pharmacy and Technology. 2023; 16(4): 1857-60.
34.    Mohammed AS, Al-Hassani AN, Alrawi RA, Tawfeeq RD. The protective effect of taurine, piracetam and vinpocetine on etoposide-induced inflammation and brain injury in the serum of female albino rats. Ecancermedical Science. 2023; 17:1499
35.    Zongfang Z, Wenjing L, Zhaomin C, Lei Z. Therapeutic effect of piracetam with nimodipine on vascular dementia after cerebral infarction. Pakistan Journal of Pharmaceutical Sciences. 2020; 33.
36.    Hadi HM, Shahada AR, Hussein NM, Hussein EHA. Doxorubicin Side Effects and Its Uses a new update: A narrative review. Arabian J. Drug Res. 2021; 1(1): 1-6.
37.    Moretti A, Gorini A, F Villa R. Pharmacotherapy and prevention of vascular dementia. CNS and Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS and Neurological Disorders). 2011; 10(3): 370-90.
38.    Akeel Naji H. The Psychosocial and Economic Impact of Uveitis in Iraq. Journal of Research in Applied and Basic Medical Sciences. 2021; 7(4): 207-15.
39.    Foley P. Psychopharmacology: a brief overview of its history. Neuro Psychopharmacotherapy. 2022 :621-60.
40.    Shubham Tripathi, Umesh kumar Sahu, JyotsanaMeshram, RanjeetaKumari, D.K Tripathi, Ajazuddin, Amit Alexander, Harish Sharma, Gyanesh Kumar Sahu. Formulation and characterization of Virgin Coconut Oil Emulsion (VCOE) for treatment of Alzheimer’s disease. Res. J. Pharma. Dosage Forms and Tech. 2018; 10(2): 49-54.
41.    Vivek Kumar Sharma. Current Therapeutic Strategies for Alzheimer’s disease: A Lost Direction or A Hope Remains?. Research J. Pharmacology and Pharmacodynamics. 2010; 2(3): 215-220.
42.    VV Buchake, AP Muthal, RB Saudagar , RS Bachhav. A Neurodegenerative disorder-Alzheimer disease: A Treatise. Research J. Pharmacology and Pharmacodynamics. 2010; 2(4): 268-273.
43.    Saudagar RB, Buchake VV, Bachhav RS. Role of Retinoids in treatment of Alzheimer’s disease. Research J. Pharmacology and Pharmacodynamics. 2012; 4(3): 144-149 .
44.    Abu Hajleh MN, Al-limoun M, Al-Tarawneh A, Hijazin TJ, Alqaraleh M, Khleifat K, Al-Madanat OY, Qaisi YA, AlSarayreh A, Al-Samydai A, Qaralleh H. Synergistic Effects of AgNPs and Biochar: A Potential Combination for Combating Lung Cancer and Pathogenic Bacteria. Molecules. 2023; 28(12): 4757.
45.    D Rajesh Kumar,M Siva Shankar,P Prathap Reddy, B Ram Sarath Kumar, N Sumalatha A Review on Alzheimer’s Disease. Research Journal of Pharmacology and Pharmacodynamics. 2014; 6(1): 59-63.
46.    Al-Hussaniy HA, Alburghaif AH, Naji MA. Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions. Journal of Medicine and Life. 2021; 14(5): 600-605.
47.    K. Periyanayagam, Gokila. S, K.G. Balasubramaniam, P.A.T. Jagatheeswary, J. Suriakumar, R. Parameshwari. Protective Effect of the Leaves of Solanum torvums wartz on Drosophila melanogaster against β-Amyloid Induced Alzheimer Disease. Research J. Pharm. and Tech. 2015; 8(6): 719-727.
48.    M. Vijey Aanandhi, Yeshwanth Prasanna Kumar. B, Ranadheer Chowdary. P, Praveen. D. A Review on the Role of Presenilin in Alzheimer’s Disease . Research J. Pharm. and Tech. 2018; 11(5):2149-2151.
49.    ALZobaidy MA, AlbuRghaif AH, Alhasany HA, Naji MA. Angiotensin-converting enzyme inhibitors may increase risk of severe COVID-19 infection. Annals of the Romanian Society for Cell Biology. 2021; 25(6): 17843-9.

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